Search results for "ASSOCIATION"

showing 10 items of 1747 documents

A motif-independent metric for DNA sequence specificity

2011

Abstract Background Genome-wide mapping of protein-DNA interactions has been widely used to investigate biological functions of the genome. An important question is to what extent such interactions are regulated at the DNA sequence level. However, current investigation is hampered by the lack of computational methods for systematic evaluating sequence specificity. Results We present a simple, unbiased quantitative measure for DNA sequence specificity called the Motif Independent Measure (MIM). By analyzing both simulated and real experimental data, we found that the MIM measure can be used to detect sequence specificity independent of presence of transcription factor (TF) binding motifs. We…

Biologylcsh:Computer applications to medicine. Medical informaticsDNA-binding proteinGenomeBiochemistryDNA sequencingCell Line03 medical and health scienceschemistry.chemical_compound0302 clinical medicineStructural BiologyHumansTranscription factorMolecular Biologylcsh:QH301-705.5Sequence Specificity Epigenomics Bioinformatics030304 developmental biologyEpigenomicsGenetics0303 health sciencesBase SequenceSettore INF/01 - InformaticaGenome HumanApplied MathematicsMethodology ArticleDNAComputer Science ApplicationsDNA-Binding Proteinschemistrylcsh:Biology (General)lcsh:R858-859.7Human genomeDNA microarray030217 neurology & neurosurgeryDNAAlgorithmsSoftwareGenome-Wide Association StudyProtein BindingTranscription FactorsBMC Bioinformatics
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In silico exploration of Mycobacterium tuberculosis metabolic networks shows host-associated convergent fluxomic phenotypes

2022

This article belongs to the Special Issue Computational Approaches for the Study of Biomolecular Networks

BiomolèculesTuberculosiLineageGenome-scale metabolic modelMycobacterium tuberculosisMetabolic networks<i>Mycobacterium tuberculosis</i>; lineage; host association; genome-scale metabolic model; metabolic networksMolecular BiologyBiochemistryHost association
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Distribution patterns, floristic structure and habitat requirements of the alpine river plant community Stuckenietum amblyphyllae ass. nova (Potamete…

2012

This paper discusses the floristic structure, distribution and habitat requirements of a new aquatic syntaxon, &lt;em&gt;Stuckenietum a&lt;/em&gt;&lt;em&gt;m&lt;/em&gt;&lt;em&gt;b&lt;/em&gt;&lt;em&gt;l&lt;/em&gt;&lt;em&gt;y&lt;/em&gt;&lt;em&gt;p&lt;/em&gt;&lt;em&gt;h&lt;/em&gt;&lt;em&gt;ylla&lt;/em&gt;&lt;em&gt;e &lt;/em&gt;ass. nova. Patches of the &lt;em&gt;Stuckenietum amblyphyllae &lt;/em&gt;association occur in the Pamir Alai Mountains in Middle Asia (Tajikistan). The biotope of this community represent high mountain rivers and ponds at the bottom of glacial river valleys situ- ated at elevations between 1900 and 3800 m. Patches of the &lt;em&gt;Stuckenietum amblyphyllae &lt;/em&gt;ass…

BiotopeMarshgeography.geographical_feature_categorybiologyEcologyPlant communityPlant Sciencebiology.organism_classificationnew plant associationFloristicslcsh:QK1-989GeographyHabitatAquatic plantlcsh:BotanyStuckenia amblyphylladistributionStuckeniaGlacial periodsyntaxonomyaquatic vegetation
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Distribution, floristic structure and habitat requirements of the riparian forest community Populetum talassicae ass. nova in the Central Pamir-Alai …

2013

This paper discusses the floristic structure, distribution and habitat requirements of a new forest syntaxon, &lt;em&gt;Populetum talassicae &lt;/em&gt;ass. nova. The potential range of the &lt;em&gt;Populetum talassicae &lt;/em&gt;association comprises the central Pamir-Alai and Tian-Shan Mountains in Middle Asia. The biotope of this community comprises high mountain river valleys and shore zones of mountain lakes situ- ated at elevations between 2200 and 2750 m. Phytocoenoses of the &lt;em&gt;Populetum talassicae &lt;/em&gt;association are characterized by a clear predominance in the tree layer of a characteristic species of the association ‒ &lt;em&gt;Populus talassica&lt;/em&gt;. Shrubs…

BiotopeMiddle AsiageographyMarshgeography.geographical_feature_categoryforest vegetationbiologyEcologyRange (biology)Populus talassicaalpine vegetationPlant Sciencenew plant associationbiology.organism_classificationFloristicslcsh:QK1-989HabitatJuniperus semiglobosalcsh:BotanyRiparian forestsyntaxonomyUndergrowthActa Societatis Botanicorum Poloniae
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Duration of untreated psychosis in first-episode psychosis is not associated with common genetic variants for major psychiatric conditions: results f…

2021

The EU-GEI Project is funded by the European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010–241909 (Project EU-GEI).

Bipolar DisorderTime FactorsIntelligenceGenome-wide association studyDETERMINANTSpsychosi0302 clinical medicineInterquartile rangeSettore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat.IMPUTATIONpolygenic scorepsychosis0303 health sciencesConfoundingEuropePsychiatry and Mental healthgenome-wide association studieSchizophreniaMajor depressive disorderlipids (amino acids peptides and proteins)Case-Control Studieduration of untreated psychosisBrazilHumanAdultPsychosismedicine.medical_specialtycongenital hereditary and neonatal diseases and abnormalitiesTime FactorAcademicSubjects/MED00810DISORDERS1ST EPISODEILLNESSPsychotic Disorderduration of untreated psychosi03 medical and health sciencesInternal medicinemedicineHumansBipolar disorderGENOME-WIDE ASSOCIATIONSettore MED/25 - PsichiatriaMETAANALYSIS030304 developmental biologyDepressive Disorder Majorbusiness.industryCOMPONENTSTREATMENT DELAYmedicine.diseaseTRANSTORNO BIPOLARschizophreniapolygenic scoresPsychotic DisordersCase-Control Studiesdupgenome-wide association studiesbusiness030217 neurology & neurosurgeryRegular ArticlesGenome-Wide Association Study
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Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

2016

Metformin is the first-line antidiabetic drug with over 100 million users worldwide, yet its mechanism of action remains unclear(1). Here the Metformin Genetics (MetGen) Consortium reports a three-stage genome-wide association study (GWAS), consisting of 13,123 participants of different ancestries. The C allele of rs8192675 in the intron of SLC2A2, which encodes the facilitated glucose transporter GLUT2, was associated with a 0.17% (P = 6.6 x 10(-14)) greater metformin-induced reduction in hemoglobin A1c (HbA1c) in 10,577 participants of European ancestry. rs8192675 was the top cis expression quantitative trait locus (cis-eQTL) for SLC2A2 in 1,226 human liver samples, suggesting a key role …

Blood Glucose0301 basic medicinemedicine.medical_specialtyendocrine system diseasesGenome-wide association studyType 2 diabetesPolymorphism Single NucleotideWhite PeopleBody Mass Index03 medical and health sciencesQuantitative Trait HeritableInternal medicineDiabetes mellitusGeneticsmedicineHumansHypoglycemic AgentsAlleleGlycemicGlucose Transporter Type 2Glycated HemoglobinbiologyGlucose transporternutritional and metabolic diseasesmedicine.diseaseMetformin3. Good healthMetformin030104 developmental biologyEndocrinologyDiabetes Mellitus Type 2biology.proteinGLUT2Genome-Wide Association Studymedicine.drug
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Filling the gap between Guidelines and Real World in the cardiovascular approach to the diabetic patients: the need for a call to action

2020

Blood GlucoseAmerican diabetes associationmedicine.medical_specialtybusiness.industryLow density lipoprotein cholesterolCardiovascular outcome trials Cardiovascular prevention Cardiovascular risk Diabetes mellitus type 2 Glucose-lowering drugs Therapeutical targets Blood Glucose Humans Hypoglycemic Agents Cardiovascular Diseases Diabetes Mellitus Type 2 Sodium-Glucose Transporter 2 InhibitorsCall to actionProprotein Convertase Subtilisin/Kexin 9Diabetes Mellitus Type 2Cardiovascular preventionCardiovascular DiseasesHumansHypoglycemic AgentsMedicineCardiology and Cardiovascular MedicinebusinessIntensive care medicineSodium-Glucose Transporter 2 InhibitorsGlycated haemoglobin
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Relevant associations of the glucokinase regulatory protein/glucokinase gene variation with TAG concentrations in a high-cardiovascular risk populati…

2012

The SNP rs1260326 (P446L) and rs1799884 ( − 30G&gt;A) for the glucokinase regulatory protein (GCKR) and glucokinase (GCK) genes, respectively, have been associated with opposing effects on TAG and glucose concentrations. However, their genetic modulation by diet (dietary patterns or foods) remains to be investigated. We studied 945 high-cardiovascular risk subjects aged 67 (sd 6) years who participated in the PREvención con DIeta MEDiterránea-Valencia Study. Demographic, clinical, biochemical and genetic data were obtained. Adherence to the Mediterranean diet (MD) and food intake were measured by validated questionnaires. Carriers of the L allele of GKCR had significantly higher TAG concent…

Blood GlucoseMaleHeterozygotemedicine.medical_specialtyMediterranean dietPopulationMedicine (miscellaneous)BiologyDiet MediterraneanPolymorphism Single NucleotideRisk FactorsPolymorphism (computer science)Internal medicineDiabetes mellitusmedicineHumansAlleleeducationGenetic Association StudiesTriglyceridesAdaptor Proteins Signal TransducingAgedAged 80 and overHypertriglyceridemiaGeneticseducation.field_of_studyNutrition and DieteticsGlucokinase regulatory proteinGlucokinaseMiddle Agedmedicine.diseaseCross-Sectional StudiesEndocrinologyAmino Acid SubstitutionCardiovascular DiseasesSpainbiology.proteinRed meatPatient ComplianceFemaleBritish Journal of Nutrition
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Novel genetic variant in FTO influences insulin levels and insulin resistance in severely obese children and adolescents.

2008

Background: The global prevalence of obesity and overweight is increasing rapidly among adults as well as among children and adolescents. Recent genome-wide association studies have provided strong support for association between variants in the FTO gene and obesity. We sequenced regions of the FTO gene to identify novel variants that are associated with obesity and related metabolic traits. Results: We screened exons 3 and 4 including exon-intron boundaries in FTO in 48 obese children and adolescents and identified three novel single nucleotide polymorphism in the fourth intronic region, (c.896 + 37A > G, c.896 + 117C > G and c.896 + 223A > G). We further genotyped c.896 + 223A > G in 962 …

Blood GlucoseMalemedicine.medical_specialtyAdolescentEndocrinology Diabetes and Metabolismmedicine.medical_treatmentMedicine (miscellaneous)Single-nucleotide polymorphismOverweightFTO genePolymorphism Single NucleotideBody Mass IndexYoung AdultInsulin resistanceInternal medicinemedicineHumansGenetic Predisposition to DiseaseObesityChildNutrition and Dieteticsbusiness.industryInsulinGenetic Variationmedicine.diseaseObesityGenotype frequencyEndocrinologyPhenotypeFemalemedicine.symptomInsulin ResistancebusinessBody mass indexGenome-Wide Association StudyInternational journal of obesity (2005)
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Insulin resistance and atrial fibrillation (from the Framingham Heart Study)

2011

Diabetes mellitus and obesity are increasing in prevalence and are associated with an elevated risk of atrial fibrillation (AF). Given the aging of the United States population, AF is projected to concomitantly increase in prevalence in the upcoming decades. Both diabetes and obesity are associated with insulin resistance. Whether insulin resistance is an intermediate step for the development of AF is uncertain. We hypothesized that insulin resistance is associated with an increased risk of incident AF. We examined the association of insulin resistance with incident AF using multivariate Cox proportional hazards regression analysis adjusting for the established AF risk factors (i.e., age, g…

Blood GlucoseMalemedicine.medical_specialtyPopulationArticleDISEASEBody Mass IndexFramingham Heart StudyInsulin resistanceRisk FactorsInternal medicineDiabetes mellitusAtrial FibrillationConfidence IntervalsMedicineHumansInsulinCOHORTeducationAgedProportional Hazards ModelsRetrospective StudiesMETABOLIC SYNDROMERISKeducation.field_of_studyFramingham Risk Scorebusiness.industryIncidenceHazard ratioDIABETES-MELLITUSMENASSOCIATIONmedicine.diseaseMassachusettsATHEROSCLEROSISHomeostatic model assessmentCardiologyFemaleMetabolic syndromeInsulin ResistanceCardiology and Cardiovascular MedicinebusinessFollow-Up StudiesAmerican Journal of Cardiology
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