Search results for "ASV"

Immunological and prognostic significance of tumour necrosis in colorectal cancer

2023

Abstract Background Colorectal cancer (CRC) causes the second most cancer deaths worldwide, but the disease course varies according to tumour characteristics and immunological factors. Our objective was to examine the associations of tumour necrosis with tumour characteristics, immune cell infiltrates, serum cytokine concentrations, as well as prognosis in CRC. Methods Three independent CRC cohorts, including 1413 patients, were analysed. Associations of the areal percentage of tumour necrosis with clinicopathologic parameters, tumour infiltrating immune cells, cytokine concentrations in systemic and mesenteric vein blood, and survival were examined. Results Higher tumour necrosis percentag…

Spatially resolved multimarker evaluation of CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint expression and macrophage polarisation in colorectal cancer

2023

Abstract Background The CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint interaction may promote cancer progression, but the expression patterns and prognostic significance of PD-L1 and PD-1 in the colorectal cancer microenvironment are inadequately characterised. Methods We used a custom 9-plex immunohistochemistry assay to quantify the expression patterns of PD-L1 and PD-1 in macrophages, T cells, and tumour cells in 910 colorectal cancer patients. We evaluated cancer-specific mortality according to immune cell subset densities using multivariable Cox regression models. Results Compared to PD-L1– macrophages, PD-L1+ macrophages were more likely M1-polarised than M2-polarised and located close…

Exploring Finnish Guidance Counselors’ Conceptions of Career Management Skills

2020

This article reports the findings from a phenomenographic investigation into guidance counselors’ conceptions of career management skills (CMS). The results show that CMS was conceived as (a) information-based knowledge, (b) personal skills development, (c) interpersonal skills development, and (d) autonomous application of skills. The differences appeared along six dimensions of variation that included awareness of CMS, emphasis, promotion of CMS, teaching practice, assessment, and attitude. The findings give us a more profound understanding of critical aspects that may have an important role in the development of individual’s CMS.

CISV-kesäkylä kulttuurienvälisenä kasvattajana ja kokemuksellisen oppimisen mahdollistajana : kesäkylän vaikutukset 12-13-vuotiaiden oppilaiden koulu…

2009

China's economic, environmental and social development in crossfire : province-specific analysis of China's ecological modernization and sustainabili…

2014

Häyhä, Laura. China’s Economic, Environmental and Social Development in Crossfire – Province-specific Analysis of China’s Ecological Modernization and Sustainability. Master thesis. Autumn 2014. Supervisor: Pertti Jokivuori. Sociology. University of Jyväskylä. Pages 89 + 1 appendix. This study concentrated to examine ecological modernization process and sustainability of Chinese provinces. The examination focused on the differences between the westernmost and the easternmost China. Data of Chinese Statistical Yearbook was used during the years 2001–2010. Analyses were implemented with SPSS 20. and Excel 2010. Among general statistical analysis, Principal Component Analysis and a relatively …

Study of the flying geese theory from a political point of view : a Japanese propaganda argument in the post world war II era

2009

The Flying Geese Theory (gankoo keitai hattenron 雁行形態発展論), dating from 1932, is one of the rare cases of a scientific theory that was used as a part of Japanese wartime propaganda, and which also survived and succeeded in the postwar era. It was used to legitimize the 'New Order in East Asia (TōA shinchitsujo 東亜新秩序) in 1938, and the new formulation of the 'Greater East Asia Co-Prosperity Sphere‘ (Dai TōA kyōeiken大東亜共栄圏) in 1940. Later in the 1980s the Flying Geese Theory/Pattern became the most successful candidate for explaining the expansion of ‗Asian economical miracles‘ in the postwar era. This study focuses on this famous piece of economical and political rhetoric. The intention is to …

The Mediterranean diet could be an exceptional support for patients with chronic renal disease

2020

Chronic renal disease (CKD) is a social problem affecting millions of patients characterized by loss of renal function and related to metabolic diseases. The approach from the dietary point of view to this problem could be a perfect strategy to slow down the progression of the disease and at the same time the problems of malnutrition typical of CKD. Several studies show that the Mediterranean diet (MD) may play a key role in the control of the early stages of the disease. Even if the MD showed to be the best diet for the control of metabolic diseases and for the general well-being, in the case of the patient with CKD, should be adapted in what is called the DASH diet, characterized by the t…

Extended music education enhances the quality of school life

2013

The claim of whether music education can create social benefits in the school environment was tested in 10 Finnish schools with an extended music curricular class and control classes. The quality of school life (QSL) was assessed by a representative sample (N=735) of pupils at years 3 and 6 (9- and 12-years-olds). The results showed that extended music education enhances the QSL, particularly in areas related to general satisfaction about the school and a sense of achievement and opportunity for students. Differences related to the schools and gender did not account for the results. A follow-up study examined whether the increase in critical QSL variables was related to music. This analysis…

Climate change reshuffles northern species within their niches

2022

Climate change is a pervasive threat to biodiversity. While range shifts are a known consequence of climate warming contributing to regional community change, less is known about how species' positions shift within their climatic niches. Furthermore, whether the relative importance of different climatic variables prompting such shifts varies with changing climate remains unclear. Here we analysed four decades of data for 1,478 species of birds, mammals, butterflies, moths, plants and phytoplankton along a 1,200 km high latitudinal gradient. The relative importance of climatic drivers varied non-uniformly with progressing climate change. While species turnover among decades was limited, the …

Large stocks of peatland carbon and nitrogen are vulnerable to permafrost thaw

2020

Significance Over many millennia, northern peatlands have accumulated large amounts of carbon and nitrogen, thus cooling the global climate. Over shorter timescales, peatland disturbances can trigger losses of peat and release of greenhouses gases. Despite their importance to the global climate, peatlands remain poorly mapped, and the vulnerability of permafrost peatlands to warming is uncertain. This study compiles over 7,000 field observations to present a data-driven map of northern peatlands and their carbon and nitrogen stocks. We use these maps to model the impact of permafrost thaw on peatlands and find that warming will likely shift the greenhouse gas balance of northern peatlands. …