Search results for "ATAL"
showing 10 items of 10591 documents
Organocatalytic Domino Oxa-Michael/1,6-Addition Reactions: Asymmetric Synthesis of Chromans Bearing Oxindole Scaffolds.
2016
An asymmetric organocatalytic domino oxa-Michael/1,6-addition reaction of ortho-hydroxyphenyl-substituted para-quinone methides and isatin-derived enoates has been developed. In the presence of 5 mol % of a bifunctional thiourea organocatalyst, this scalable domino reaction affords 4-phenyl-substituted chromans bearing spiro-connected oxindole scaffolds and three adjacent stereogenic centers in good to excellent yields (up to 98 %) and with very high stereoselectivities (up to >20:1 d.r., >99 % ee).
A Mixture of Dietary Plant Sterols at Nutritional Relevant Serum Concentration Inhibits Extrinsic Pathway of Eryptosis Induced by Cigarette Smoke Ext…
2023
Cell death program of red blood cells (RBCs), called eryptosis, is characterized by activation of caspases and scrambling of membrane phospholipids with externalization of phosphatidylserine (PS). Excessive eryptosis confers a procoagulant phenotype and is implicated in impairment of microcirculation and increased prothrombotic risk. It has recently been reported that cigarette smokers have high levels of circulating eryptotic erythrocytes, and a possible contribution of eryptosis to the vaso-occlusive complications associated to cigarette smoke has been postulated. In this study, we demonstrate how a mixture of plant sterols (MPtS) consisting of β-sitosterol, campesterol and stigmasterol, …
Scales of participation and multi-scalar citizenship in EU participatory governance
2020
The EU still has a democratic deficit and its legitimacy is strongly questioned. This reveals the importance of citizenship and participation in the context of the challenges the EU faces today. The article contributes to the current discussions on the shifting frameworks of participation and citizenship through empirical research into the EU’s participatory governance. It asks how participation is framed in terms of scale and how these scalar framings are used to formulate citizenship in selected projects funded by the EU programmes on citizenship and culture. This microlevel analysis yields new insights into the politics of scale in the EU’s multilevel participatory governance. Frame anal…
THE CIVIC SELF-CONSCIOUSNESS OF CONTEMPORARY SECONDARY SCHOOL STUDENTS IN THE ASPECT OF THE HUMANISTIC PARADIGM OF EDUCATION
2020
Civic self-consciousness is a topical issue in present-day Latvia. After regaining of independence and joining the European Union, there appeared an opportunity to ensure real freedom and genuine democracy for all inhabitants in Latvia. Thus, new conditions were created for the development of civic self-consciousness in senior secondary school students. New guidelines are developed in the European system of education according to the new understanding of humanism. The key reference-point is the understanding that the main goal of education is to support the development of personality that will become an EU citizen and a professional. The study established that it is necessary to develop ci…
Solubility-Driven Isolation of a Metastable Nonagold Cluster with Body-Centered Cubic Structure.
2020
The conventional synthetic methodology of atomically precise gold nanoclusters using reduction in solutions offers only thermodynamically most stable nanoclusters. We report herein a solubility‐driven isolation strategy to access the synthesis of a metastable gold cluster. The cluster, with the composition of [Au 9 (PPh 3 ) 8 ] + ( 1 ), displays an unusual, nearly perfect body‐centered‐cubic (bcc) structure. As revealed by ESI‐MS and UV/Vis measurement, the cluster is metastable in solution and converts to the well‐known [Au 11 (PPh 3 ) 8 Cl 2 ] + ( 2 ) within just 90 min. DFT calculations revealed that while both 1 and 2 are eight‐electron superatoms, there is a driving force to convert 1 …
Severe Perinatal Hypoxic-Ischemic Brain Injury Induces Long-Term Sensorimotor Deficits, Anxiety-Like Behaviors and Cognitive Impairment in a Sex-, Ag…
2019
Perinatal brain injury (PBI) leads to neurological disabilities throughout life, from motor deficits, cognitive limitations to severe cerebral palsy. Yet, perinatal brain damage has limited therapeutic outcomes. Besides, the immature brain of premature children is at increased risk of hypoxic/ischemic (HI) injury, with males being more susceptible to it and less responsive to protective/therapeutical interventions. Here, we model in male and female C57BL/6 mice, the impact of neonatal HI and the protective effects of neonatal handling (NH), an early life tactile and proprioceptive sensory stimulation. From postnatal day 1 (PND1, modeling pre-term) to PND21 randomized litters received either…
SULL'IMPIEGO SPERIMENTALE DI UN COLLANTE BIOLOGICO NELLE ANASTOMOSI INTESTINALI NEL RATTO IN ACCRESCIMENTO
1980
The problems that arise in the preparation of the anastomoses of channelicular organs have not found a unique solution. In fact, when it is necessary to proceed to the synthesis of very small gauge hollow organs as in the accreting subjects (infants) the risk of formation of a stenosis is always present despite the various techniques practiced. In recent years several experimental researches have been carried out in order to verify the validity of biological adhesives in intestinal anastomoses in rapidly growing animals. For this purpose we have chosen the rat whose rapidity of somatic growth permits an evaluation in times contained
Cambios en el comercio exterior de los países del este. La difícil reinserción en Europa
1999
Changes in the foreign trade of the countries of the East. The difficult assimilation into Europe. The direction of the trading lines of the post-communist countries has been modified by the political and economical changes of the countries of the East of Europe, the dismantling of the COMECON, as well as by the disintegration of the USSR and the detente in the international relationships. During the forty years that the COMECON was prevailing, that region centred its attention on the USSR, but nowadays the East looiks at the West, concretaly at the European Union and more exactly at Germany. The composition of the imports and exports reveals the marked dependence on Central and Eastern Eur…
Réseaux territoriaux & Dynamiques territoriales : Apports de l’Intelligence Territoriale
2015
National audience; "L’intelligence territoriale est le projet scientifique polydisciplinaire dont l’objet est le développement durable des territoires et dont les communautés territoriales sont les sujets." Jean-Jacques GIRARDOT, 2013Il s'agit d'une intelligence collective qui se fonde, d’une part sur l’interaction entre chaque être humain et son environnement et, d’autre part, sur les relations entre les personnes.Les réseaux dee structures, d’institutions, de collectivités, d’associations, ONGs, d’acteurs, de citoyens, abolissent certaines frontières, en reconstruisent d’autres, permettent de désectoriser, de favoriser l’approche globale...De multiples vertus, comme de multiples ennuis ! …
Le discours génocidaire dans l'historiographie catalane : entre pratiques mémorielles et enjeux identitaires
2016
International audience