Search results for "ATAM"
showing 10 items of 309 documents
Frontiers of metal-coordinating drug design
2020
INTRODUCTION: The occurrence of metal ions in biomolecules is required to exert vital cellular functions. Metal-containing biomolecules can be modulated by small-molecule inhibitors targeting their metal-moiety. As well, the discovery of cisplatin ushered the rational discovery of metal-containing-drugs. The use of both drug types exploiting metal–ligand interactions is well established to treat distinct pathologies. Therefore, characterizing and leveraging metal-coordinating drugs is a pivotal, yet challenging, part of medicinal chemistry. AREA COVERED: Atomic-level simulations are increasingly employed to overcome the challenges met by traditional drug-discovery approaches and to compleme…
Tratamiento jurídico de una enfermedad social. Los trastornos de la conducta alimentaria (TCA)
2018
The boundless increase of people suffering from an Eating Disorder (ED), makes necessary to develop measures related to other factors, in order to overcome the ones characterized of being strictly sanitary. The disease has become a social and cultural phenomenon. The exaltation of the cult to the body, with the stereotype of the extreme thinness linked with beauty and success is causing that, particularly young people, try to achieve an image which, in many cases, can jeopardize their health, that is the reason why the rearrangement of values has become an objective of paramount importance. Therefore, the fight against this social illness requires legal actions in order to prevent it from g…
Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins
2019
Incretins are metabolic hormones released after a meal that increase insulin secretion from pancreatic β-cells. The two main incretins are the intestinal peptides glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. Both induce a decrease in glycemia, slow down the absorption of nutrients, and are inactivated by the enzyme dipeptidyl peptidase-4. Recently, incretin-based therapies have become a useful tool to treat diabetic patients, and different studies have focused on the identification of glucagon-like peptide-1 receptor agonists, including those of natural origin. This review focuses on the new findings of medicinal plants and natural products as possible active ag…
Oral leukoplakia, a clinical-histopathological study in 412 patients
2020
Background A retrospective clinical-histopathological study was made of the evolution of oral leukoplakia over time, staging the disease according to the classification of van der Waal. Material and Methods A study was made of 412 patients with oral leukoplakia, analyzing the corresponding clinical factors and histopathological findings; assessing associations between the different clinical presentations and epithelial dysplasia; and evaluating the factors influencing malignant transformation of the lesions. Results Clinically, homogeneous presentations were seen to predominate (n = 336, 81.6%), while histologically most of the lesions exhibited no dysplastic changes (n = 271; 65.7%). Stage…
El aprendizaje del concepto biológico de población: cómo pueden las ciencias sociales y las matemáticas colaborar con la didáctica de la biología
2008
El concepto de población vertebra gran parte de las áreas en las que se divide la Biología, como son la genética, la ecología, todas aquellas clásicas que implican taxonomía (botánica, zoología, microbiología, etc.) o la más moderna biología de la conservación. También es importante su conocimiento para comprender e interpretar adecuadamente la evolución y sus implicaciones socioculturales en la historia de la humanidad. Además desempeña un papel básico en otras disciplinas como las Matemáticas o las Ciencias Sociales, con las cuales puede tener elementos comunes. Permite, por lo tanto, trabajar de forma interdisciplinar, ofreciendo al alumnado una visión integradora, algo poco usual dado e…
Medico-legal study of death in custody by excited delirium. A case report
2014
En este artículo exponemos los resultados de la autopsia de un varón joven que falleció en el hospital por un cuadro de delirium agitado. Es un síndrome caracterizado generalmente por agitación psicomotriz, agresividad y puede producir muerte súbita, en ocasiones durante la aplicación de métodos de contención mecánica por los Cuerpos de Seguridad del Estado o personal sanitario. Está típicamente asociado al consumo de drogas de abuso, como la cocaína. En estos casos, estará incluida en el grupo de muertes en custodia, que es aquella que se produce cuando la víctima se encuentra privada de libertad. Tiene una indudable repercusión médico legal, puesto que se considera prototipo de muerte sos…
Theoretical and Experimental Comparison between the Resistance Components of a fast Catamaran in different Configurations
2009
The investigation performed by the Authors represents the most recent development of a research presented in [1] and [2], in which the geometrical solutions of the hull have been obtained through an optimization process, made by using the CFD numerical methods. The most important result of this optimization was the wave resistance reduction, which arrived up to 20% of the total initial resistance. In this further process the hull catamaran model has been built and tested at the towing tanks of the Universities of Naples and Trieste. The results obtained in the numerical process have been compared with the experimental ones and the reliability of the numerical results will be proved. Then th…
Tratamiento digital de señales. Problemas y ejercicios resueltos
2003
El documento es un libro de problemas y ejercicios de Tratamiento Digital de Señales. Este libro publicado por Prentice-Hall en 2003, se ofrece actualmente como recurso de acceso abierto tras su descatalogación. En él se ofrecen ejemplos de problemas y ejercicios resueltos de Tratamiento Digital de Señales, a los que previamente se introduce la base teórica suficiente como para seguir el desarrollo del texto. El contenido es el siguiente: Señales y sistemas en tiempo discreto; Análisis frecuencial de señales y sistemas; Transformada z; Realización de sistemas en tiempo discreto; Efectos de longitud de palabra finita; Diseño de filtros digitales; Sistemas adaptativos. That document is a book…
Anti-angiogenic drug loaded liposomes: Nanotherapy for early atherosclerotic lesions in mice.
2018
Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190540 También participan en la elaboración de este artículo científico: Aracely Calatayud-Pascual, Alicia López-Castellano, Elena P. Albelda, Enrique García-España, Luis Martí-Bonmatí, Juan C. Frias y M. Teresa Albelda. Fumagillin-loaded liposomes were injected into ApoE-KO mice. The animals were divided into several groups to test the efficacy of this anti-angiogenic drug for early treatment of atherosclerotic lesions. Statistical analysis of the lesions revealed a decrease in the lesion size after 5 weeks of treatment.
Towards a more sustainable food Supply chain: opening up invisible waste in food service
2016
Future challenges to the global food supply chain are complex. In order to embrace sustainability, companies should change their management practices towards more efficient resource use. Food waste being a misuse of resources, we identify its causes and possible ways of minimising it. To achieve this goal, we conducted explorative research with qualitative and quantitative data through in-depth semi-structured interviews and an open questionnaire with top Spanish food service companies. Results show that most businesses mainly tend to minimise food waste according to economic criteria, without taking into account the social, ethical or environmental factors. As a consequence, just “visible”…