Search results for "ATF"
showing 10 items of 565 documents
Germline loss-of-function variants in the BARD1 gene are associated with early-onset familial breast cancer but not ovarian cancer
2019
Background The role of the BARD1 gene in breast cancer (BC) and ovarian cancer (OC) predisposition remains elusive, as published case-control investigations have revealed controversial results. We aimed to assess the role of deleterious BARD1 germline variants in BC/OC predisposition in a sample of 4920 BRCA1/2-negative female BC/OC index patients of the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC). Methods A total of 4469 female index patients with BC, 451 index patients with OC, and 2767 geographically matched female control individuals were screened for loss-of-function (LoF) mutations and potentially damaging rare missense variants in BARD1. All patients met the …
Virtual Clinical and Precision Medicine Tumor Boards-Cloud-Based Platform-Mediated Implementation of Multidisciplinary Reviews Among Oncology Centers…
2021
Background Multidisciplinary tumor boards play a pivotal role in the patient-centered clinical management and in the decision-making process to provide best evidence-based, diagnostic, and therapeutic care to patients with cancer. Among the barriers to achieve an efficient multidisciplinary tumor board, lack of time and geographical distance play a major role. Therefore, the elaboration of an efficient virtual multidisciplinary tumor board (VMTB) is a key point to successfully obtain an oncology team and implement a network among health professionals and institutions. This need is stronger than ever during the COVID-19 pandemic. Objective This paper presents a research protocol for an obse…
Ontological information system for the selection of technologies for the treatment and disposal of organic waste: engineering and educational aspects
2021
The article proves a problem of information processing in the field of the structuring of information and decision-making in environmental engineering, including education in this field. This article presents the ontology-information model that was used to systematize waste treatment equipment. The article presents the use of an ontological algorithm “Polyhedron” for engineers and teachers. The algorithm consists of integrating ontological solutions from abstract to specific. The proposed model consists of a general ontology of “waste treatment technologies selection”, “waste treatment equipment selection” and “Ontology for the analysis of scientific publications”. Users of the system can i…
Diversification and performance in the mobile app market: The role of the platform ecosystem
2019
Abstract We examine the effect of app developers' product line diversification decision on their performance and shed light on whether the type of platform ecosystem (open versus closed) where they commercialize apps influences this effect. We compare the revenue performance of diversified and specialized developers in Apple's App Store and Google Play. We show that in the Apple's App Store (closed platform) diversified developers always display lower performance than their specialized counterparts. In Google Play (open platform) diversification is beneficial in categories where diversified developers have predominant market share, whereas it is detrimental in categories dominated by specia…
Datortīklu mācību platformas pārveide
2021
Šis dokuments ir bakalaura darbs, kurš izstrādāts Latvijas Universitātes Datorikas fakultātes Datorzinātnes studiju programmas ietvaros. Dokumentā tiek veikti pētījumi par datortīklu un datorsistēmu mācību platformas ReSeLa pārveidi, kas iekļauj izpēti par populāru tiešsaistes mācību platformu iezīmēm un veicamo uzlabojumu tehnoloģiskajiem risinājumiem. Balstoties uz veiktajiem pētījumiem, tiek veikta sākotnējā jaunās platformas izstrāde, un dokumentā aprakstīta tās struktūra, API, izvēlētie risinājumi, trūkumi un nepieciešamie uzlabojumi, kā arī tiek aprakstīta un uzstādīta testa vide tās galvenajai ārējai saskarnei – OpenStack.
Heuristics for solving the parameter tuning problem in motion cueing algorithms.
2017
[ES] Diversos tipos de plataformas robóticas son empleadas habitualmente para la generación de claves gravito-inerciales en simuladores. Además del control de los actuadores, dichas plataformas deben ejecutar complejos algoritmos de control conocidos como algoritmos de washout, que deben ser ajustados para que el movimiento generado sea similar al simulado. El ajuste de dichos algoritmos es complejo por el elevado número de parámetros que poseen. Además, dicho ajuste se ha venido realizando tradicionalmente de modo manual mediante evaluaciones subjetivas. En este trabajo, los autores proponen un método automático de ajuste basado en optimización heurística, métricas objetivas, y simulación …
Cursos en línea masivos y abiertos en educación superior. Un análisis desde su oferta
2016
Purpose: The aim of this study is to analyze the factors influencing the MOOC supply level. Specifically, this paper analyzes certain internal and strategic factors associated with universities, such as prestige, public or private status, age, size (measured by the number of faculty members or students) and region. Design/methodology: We apply a descriptive methodology and then use multivariate analysis to test five hypotheses related to the institutional profile of 151 universities in 29 countries. Empirical evidence is provided from universities offering MOOCs through the four of the most commonly used private global platforms that emerged as part of the booming MOOC movement (Udacity, Co…
LES VARIATIONS DU NIVEAU MARIN SUR LE BASSIN DE PARIS AU BATHONIEN-CALLOVIEN. IMPACTS SUR LES COMMUNAUTÉS BENTHIQUES ET SUR L'ÉVOLUTION DES ORNITHELL…
1992
The study deals with the biological impacts of sea-Ievel changes on evolution of a Jurassic benthic fossil group (Ornithellida, Brachiopoda). The different time and scale at which the shifts in marine environments occur leads to the recognition of three interacting dynamic systems: environmental, communities, populations dynamics. The analysis is thus divided into a three steps hierarchy: sequence stratigraphy, analysis of the diversity of brachiopod assemblages, and analysis of morphological variations within omithellid populations. Sequence stratigraphy of the Dogger marly and carbonate successions in the Paris basin provides accurate correlations of depositional environments from shallow…
The influence of the stomatognathic system on explosive strength: A pilot study
2015
[Purpose] Recent findings suggest there is an interesting interaction between the stomatognathic system and the musculoskeletal system. The aim of this study was therefore to examine the influence of the temporomandibular joint on the explosive strength of the lower limbs. [Subjects and Methods] An observational study was carried out. The subjects were 60 male football players who voluntarily participated in the investigation. After a warm-up phase of 10 minutes, each participant performed three Squat Jumps (SJ) with different mandible positions: mouth closed and mouth open. SJ heights were recorded using a Sensor Medica force platform and the FreeMed system. [Results] Sixty participants we…
Ladinian carbonates of the Cabo Cope Unit (Betic Cordillera, SE Spain): a tethys-maláguide palaeogeographic gateway.
2003
7 pages, 4 figures.