Search results for "AVAS"

Exploring the Virchow-Robin spaces function: A unified theory of brain diseases.

2016

Background: Cerebrospinal fluid (CSF) transport across the central nervous system (CNS) is no longer believed to be on the conventional lines. The Virchow-Robin space (VRS) that facilitates CSF transport from the basal cisterns into the brain interstitial fluid (ISF) has gained interest in a whole new array of studies. Moreover, new line of evidence suggests that VRS may be involved in different pathological mechanisms of brain diseases. Methods: Here, we review emerging studies proving the feasible role of VRS in sleep, Alzheimer's disease, chronic traumatic encephalopathy, and traumatic brain injury (TBI). Results: In this study, we have outlined the possible role of VRS in different path…

Dermatopatología de la oclusión intraluminal vascular: parte II (coagulopatías, émbolos y miscelánea)

2021

Resumen: La patología vascular oclusiva es causante de diversas y variadas manifestaciones clínicas, algunas de ellas con catastróficas consecuencias para el paciente. Dado que las causas de tal oclusión son muy variadas, hemos abordado en un artículo previo reciente en esta misma revista las causas trombóticas. En el presente artículo recopilamos diversas causas adicionales de oclusión intravascular. Abstract: Vascular occlusion has multiple, diverse clinical manifestations, some of which can have grave consequences for patients. It also has a wide variety of causes, including thrombi, which we recently addressed in part I of this review. In this second part, we look at additional causes o…

Intravascular Papillary Endothelial Hyperplasia: Sonographic and Magnetic Resonance Imaging Appearance With Histopathologic Correlation

2016

Ģeogrāfija. Ģeoloģija. Vides zinātne: referātu tēzes

2008

Clinical use of intracoronary imaging. Part 1: guidance and optimization of coronary interventions. An expert consensus document of the European Asso…

2018

This Consensus Document is the first of two reports summarizing the views of an expert panel organized by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) on the clinical use of intracoronary imaging including intravascular ultrasound (IVUS) and optical coherence tomography (OCT). The first document appraises the role of intracoronary imaging to guide percutaneous coronary interventions (PCIs) in clinical practice. Current evidence regarding the impact of intracoronary imaging guidance on cardiovascular outcomes is summarized, and patients or lesions most likely to derive clinical benefit from an imaging-guided intervention are identified. The relevance of the u…

Sodium/hydrogen exchange inhibition with cariporide reduces leukocyte adhesion via P-selectin suppression during inflammation

2008

Background and purpose: The Na+/H+ exchange (NHE) inhibitor cariporide is known to ameliorate ischaemia/reperfusion (I/R) injury by reduction of cytosolic Ca2+ overload. Leukocyte activation and infiltration also mediates I/R injury but whether cariporide reduces I/R injury by affecting leukocyte activation is unknown. We studied the effect of cariporide on thrombin and I/R induced leukocyte activation and infiltration models and examined P-selectin expression as a potential mechanism for any identified effects. Experimental approach: An in vivo rat mesenteric microcirculation microscopy model was used with stimulation by thrombin (0.5 μ ml−1) superfusion or ischaemia (by haemorrhagic shock…

Changes induced by pravastatin treatment on hemostatic and fibrinolytic patterns in patients with type IIb hyperlipoproteinemia

1994

Abstract A randomized, double-blind, parallel-group study of pravastatin versus placebo was carried out for 24 weeks in 20 patients with type IIb primary hyperlipoproteinemia. Total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, blood glucose, apolipoproteins (apo) A1 and B, and lipoprotein (a) (Lp[a]) levels were determined. A venous occlusion test was also performed in all patients. Pre- and postvenous occlusion tests were determined: tissue plasminogen activator antigen (t-PA[Ag]), plasminogen activator inhibitor (PAI) activity, factor VII, fibrinogen, plasminogen, and hematocrit. Compared with placebo, pravastatin signi…

Journal of the Institute of Latvian History

2023

Atbalsts LU Latvijas vēstures institūta LU ilgtermiņa saistību izpildei 2020.-2023. gadā ("Latvijas Vēstures Institūta Žurnāls")

Jelgavas pilsētas pašvaldības darbības izvērtējums un attīstības perspektīvas

2016

Bakalaura darba tēma ir: „Jelgavas pilsētas pašvaldības darbības izvērtējums un attīstības perspektīvas”, darbā tiek pētīta jelgavas pašvaldības darbība kas saistīta ar budžeta līdzekļu apguvi pret to sākotnējo ieceri analizējot cik sekmīgi tā ir noritējusi. Pētījuma mērķis ir uz pieejamās informācijas pamata analizēt Jelgavas pilsētas pašvaldības darbību, izvērtējot tās darbības efektivitāti, kā arī tās ilgtermiņa attīstības ieceres, izvīrzītais izpētes jautājums ir: vai Jelgavas pilsētas pašvaldības darbību kopums, kas saistīts ar pilsētas attīstību laika posmā no 2012. līdz 2014. gadam ir uzskatāms par pietiekami sekmīgu, lai uz tā pamata varētu balstīt savus attīstības scenārijus. Darba…

Glutathione in Cancer Biology and Therapy

2006

The glutathione (GSH) content of cancer cells is particularly relevant in regulating mutagenic mechanisms, DNA synthesis, growth, and multidrug and radiation resistance. In malignant tumors, as compared with normal tissues, that resistance associates in most cases with higher GSH levels within these cancer cells. Thus, approaches to cancer treatment based on modulation of GSH should control possible growth-associated changes in GSH content and synthesis in these cells. Despite the potential benefits for cancer therapy of a selective GSH-depleting strategy, such a methodology has remained elusive up to now. Metastatic spread, not primary tumor burden, is the leading cause of cancer death. Fo…