Search results for "Abstract"

Starting Easy: FFR in a High-Grade Stenosis

2016

A simple representative case of FFR in a high-grade stenosis. The gradient is confirmed by pushing the sensor forward. Equalization is confirmed at the end of the procedure.

Stereotype Threat Effect on a Simple Motor Task: An Investigation of the Visuo-Spatial Working Memory

2020

Purpose: Based on the Chalabaev et al. (2013) study showing that in a Stereotype Threat (ST) situation the velocity of force production in a simple motor task can be affected, this study aimed to r...

1976

tert-Butoxy radicals were generated by decomposing di-tert-butyl hyponitrite. The relative reactivities of substrates were measured from the ratio of tert-butanol and acetone formed. Polystyrene was found to be less reactive than model compounds. Activation parameters for the hydrogen abstraction reaction for cumene, 3-phenylpentane, and 2,4-diphenylpentane are reported and show small differences for the enthalpy of activation; large negative values for the entropy of activation demonstrate the importance of steric hindrance in the hydrogen abstracting step. 2,3-Diphenylbutane as model compound for head to head links in polystyrene exhibits low reactivity, whereas 2,5-diphenylhexane, a mode…

Bond-based 3D-chiral linear indices: Theory and QSAR applications to central chirality codification

2008

The recently introduced non-stochastic and stochastic bond-based linear indices are been generalized to codify chemical structure information for chiral drugs, making use of a trigonometric 3D-chirality correction factor. These improved modified descriptors are applied to several well-known data sets to validate each one of them. Particularly, Cramer's steroid data set has become a benchmark for the assessment of novel quantitative structure activity relationship methods. This data set has been used by several researchers using 3D-QSAR approaches such as Comparative Molecular Field Analysis, Molecular Quantum Similarity Measures, Comparative Molecular Moment Analysis, E-state, Mapping Prope…

Combined dynamic response of primary and multiply connected cascaded secondary subsystems

1991

A method is proposed for the deterministic and stochastic non-stationary analysis of linear composite systems with cascaded secondary subsystems subjected to a seismic input. This method makes it possible to evaluate, by means of a unitary formulation, the deterministic and non-stationary stochastic response of both classically and non-classically damped subsystems and of secondary subsystems multiply supported on the primary one, as well as the ground. The proposed procedure is very efficient from a computational point of view, because of the Kronecker algebra systematically employed. Indeed, by using this algebra, it is possible to obtain in a very compact and elegant form the eigenproper…

Set-valued and fuzzy stochastic differential equations driven by semimartingales

2013

Abstract In the paper we present set-valued and fuzzy stochastic integrals with respect to semimartingale integrators as well as their main properties. Then we study the existence of solutions to set-valued and fuzzy-set-valued stochastic differential equations driven by semimartingales. The stability of solutions is also established.

A convolutional neural network for virtual screening of molecular fingerprints

2019

In the last few years, Deep Learning (DL) gained more and more impact on drug design because it allows a huge increase of the prediction accuracy in many stages of such a complex process. In this paper a Virtual Screening (VS) procedure based on Convolutional Neural Networks (CNN) is presented, that is aimed at classifying a set of candidate compounds as regards their biological activity on a particular target protein. The model has been trained on a dataset of active/inactive compounds with respect to the Cyclin-Dependent Kinase 1 (CDK1) a very important protein family, which is heavily involved in regulating the cell cycle. One qualifying point of the proposed approach is the use of molec…

Measuring diversity. A review and an empirical analysis

2021

Abstract Maximum diversity problems arise in many practical settings from facility location to social networks, and constitute an important class of NP-hard problems in combinatorial optimization. There has been a growing interest in these problems in recent years, and different mathematical programming models have been proposed to capture the notion of diversity. They basically consist of selecting a subset of elements of a given set in such a way that a measure based on their pairwise distances is maximized to achieve dispersion or representativeness. In this paper, we perform an exhaustive comparison of four mathematical models to achieve diversity over the public domain library MDPLIB, …

Memetic algorithms and memetic computing optimization: A literature review

2012

Abstract Memetic computing is a subject in computer science which considers complex structures such as the combination of simple agents and memes, whose evolutionary interactions lead to intelligent complexes capable of problem-solving. The founding cornerstone of this subject has been the concept of memetic algorithms, that is a class of optimization algorithms whose structure is characterized by an evolutionary framework and a list of local search components. This article presents a broad literature review on this subject focused on optimization problems. Several classes of optimization problems, such as discrete, continuous, constrained, multi-objective and characterized by uncertainties…

Complex Detection in Protein-Protein Interaction Networks: A Compact Overview for Researchers and Practitioners

2012

The availability of large volumes of protein-protein interaction data has allowed the study of biological networks to unveil the complex structure and organization in the cell. It has been recognized by biologists that proteins interacting with each other often participate in the same biological processes, and that protein modules may be often associated with specific biological functions. Thus the detection of protein complexes is an important research problem in systems biology. In this review, recent graph-based approaches to clustering protein interaction networks are described and classified with respect to common peculiarities. The goal is that of providing a useful guide and referenc…