Search results for "Abstracts"

5.4 BIOLOGICAL AND EPIDEMIOLOGICAL EXAMINATION OF TRANSDIAGNOSTIC AND SPECIFIC SYMPTOM DIMENSIONS AT PSYCHOSIS ONSET: FINDINGS FROM THE EUGEI STUDY

2018

Abstract Background Current diagnostic models of psychosis have been questioned since Kraepelin’s original dichotomy of dementia praecox and manic depression. Indeed, increasing evidence has suggested that a dimensional approach might be a valid alternative platform for research. However, while an increasing number of studies have investigated how environmental risk factors for affective and non-affective psychosis map onto symptom dimensions, only a few have examined these dimensions in relation to genetic variants as summarised by Polygenic Risk Score (PRS). Furthermore, no studies have examined the putative effect of PRS for Schizophrenia (SZ), Bipolar Disorder (BP), and Major Depressive…

T110. FIRST EPISODE PSYCHOTIC PATIENTS WITH A HISTORY OF FREQUENT CANNABIS USE EXPRESS MORE POSITIVE SYMPTOMS AT ILLNESS ONSET THAN THOSE WHO NEVER U…

2018

Abstract Background Robust evidence has demonstrated that cannabis use increases the risk to develop psychotic disorders. However, a limited number of studies have investigated if and how cannabis use influences psychopathology profiles at first episode psychosis (FEP). Based on the evidence that dopamine dysfunction contributes to explain positive symptoms in psychosis, and that the main cannabis’ psychoactive component, Δ9-Tetrahydrocannabinol (THC), modulates the dopamine system, we hypothesise that: 1) positive symptoms at FEP are more common among psychotic patients who used cannabis compared with never users; 2) this association is a dose-response relationship. Methods We analyzed a s…

T215. CLINICAL PREDICTORS OF HOSPITALIZTIONS IN FIRST EPISODE PSYCHOTIC PATIENTS: A NATURALISTIC FOLLOW UP STUDY

2018

Abstract Background Some naturalistic longitudinal studies of first psychotic episodes of the last 50 years have suggested associations between psychopathology and the remission of symptoms and the clinical course of disease.1 A recent study in a large sample of patients with schizophrenia has obtained significant results using the number of hospitalizations as outcome variable.2 The main objective of this study is to know if clinical and sociodemographic variables predict the number of hospitalizations after the first psychotic episode Methods Naturalistic, longitudinal follow-up study in a sample of 212 patients of first-episode psychosis attending public mental health service in Area 5 o…

Celebrazioni di G. G. Gemmellaro ad un secolo dalla scomparsa Programma e Riassunti (Program and Abstracts).

2004

DETERMINANTS OF DNA METHYLATION BASED AGE ACCELERATION IN YOUNG AND OLDER TWIN PAIRS

2017

DNA methylation (DNAm) age, a novel marker of biological aging, has been shown to predict mortality and to be associated with physiological aging. However, the relative contribution of genetic and environmental factors to DNAm age over life span is not fully known. We estimated the magnitude of genetic and environmental factors in DNAm based age acceleration.

ROAD NETWORK HILLINESS AND DEVELOPMENT OF WALKING DIFFICULTIES AMONG COMMUNITY-DWELLING OLDER PEOPLE

2017

Aims: To study associations between objective road network hilliness and development of walking difficulties (WD) within two years, and to examine how hilliness as a perceived barrier and frequency of moving through the neighborhood affect to this.

AGING IN EUROPE AND GERIATRIC CARE

2017

Europeans are living longer than ever, and this pattern is expected to continue. The increased life expectancy is a remarkable achievement, which however poses obvious challenges for health care and geriatric assistance. There is a progressive increase of older persons living alone and in need of assistance. European countries are handling these challenges with very different approaches. There are countries and regional differences in social policies and sanitary assistance, in providers of care, in quality of the assistance and in lodging costs. The long term care models are also very different (cash benefits, public provision of care services, or hybrid rather than pure models of care). T…

CALPAIN ACTIVITY MAINTAINS GOOD HEALTH OF CENTENARIAN T CELLS; SUMMARY OF THE CALPACENT PROJECT

2017

Causes of aging-associated deterioration of human immunity, and the reasons why the immune system of the oldest old individuals (centenarians) is relatively robust, remain moot. Intracellular proteolysis system of two proteases – µ- and m-calpain – and their inhibitor – calpastatin (the calpain-calpastatin system (CCS)) - is active in resting human peripheral blood T cells, participating in maintenance of their readiness to proliferate and secrete cytokines in response to stimulation. The amounts of the CCS proteins decrease in resting T lymphocytes of healthy elderly, only to return in the centenarians to those levels seen in the young individuals. We compared the calpain activities and th…

ENVIRONMENTAL FACTORS AND ONSET OF RESTRICTED MOBILITY OUTDOORS IN OLDER ADULTS WITH OSTEOARTHRITIS

2017

The study examines how environmental factors contribute to the onset of restricted mobility outside the home among older adults with osteoarthritis. This was a prospective cohort study of adults aged 50 years and over with osteoarthritis (N=1802). Logistic regression tested the association between the onset of restricted mobility outside the home and health, sociodemographic and perceived environmental barriers (hills and steep slopes, inaccessible public buildings, poor pavement condition, lack of access to public parks or sport facilities, heavy traffic or speeding cars, and poor weather). The potential moderating role of environmental barriers on the association between health factors an…

EXECUTIVE FUNCTION AND LIFE-SPACE MOBILITY IN OLD AGE

2017

Mobility is important for maintaining independence and active participation in old age. Life-space mobility assessment incorporates the extent of mobility in terms of the distance from home, the frequency of mobility and the need of assistance for mobility. Executive function (EF) is one of the most important higher-order cognitive abilities that control and guide goal-directed actions. The aim of the study was to examine the association between EF and life-space mobility.