Search results for "Abuse"
showing 10 items of 700 documents
On cosmetically treated hair — aspects and pitfalls of interpretation
1997
Popular hair cosmetic treatments like bleaching or permanent waving were found to affect the stability of incorporated drugs and to cause alterations of the fibers at an ultrastructural level. This may result in a partial or complete loss of drug substances, depending on the particular drug molecule and on its concentration prior to the cosmetic treatment. Moreover, from literature, there is some evidence that drug molecules are not only incorporated into the growing fiber by passive diffusion from blood into the matrix cells and melanocytes, but that the substances enter the hair also via perspiration such as sweat and sebum. Since permed and bleached hair shows an enhanced sorption capaci…
Stability of opiates in hair fibers after exposure to cosmetic treatment.
1996
Abstract The stability of opiates in clipped natural human hair was investigated. Hair fibers were incubated with defined solutions of morphine, codeine and dihydrocodeine (pH 7.4) until saturated. Original opiate-positive hair samples collected from drug addicts also were examined. Commercially available bleaching as well as perming formulas (Poly Blonde Ultra®, Poly Lock®; Henkel, Dusseldorf, Germany) were applied in vitro to the hair strands of both groups under investigation. After these treatments, the drug concentration had decreased for both bleaching and permanent waving. In the spiked hair, only 2–18% of the starting solution could be found after bleaching. About 20–30% of the drug…
Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies
2020
AbstractEating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa (BN) and problem alcohol use (genetic correlation [rg], twin-based=0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge-eating, AN without binge-eating, and a BN factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], …
The Specific Role of Childhood Abuse, Parental Bonding, and Family Functioning in Female Adolescents With Borderline Personality Disorder.
2015
This study examined a broad variety of adverse childhood experiences in a consecutive sample of female adolescent inpatients with borderline personality disorder (BPD; n = 44) compared with a clinical control (CC; n = 47) group with mixed psychiatric diagnoses. BPD was diagnosed using a structured clinical interview; different dimensions of childhood adversity were assessed using the Childhood Experiences of Care and Abuse Questionnaire, the Parental Bonding Instrument, and the Family Assessment Device. A history of childhood adversity was significantly more common in patients with BPD than in the CC group. Using a multivariate model, sexual abuse (OR = 13.8), general family functioning (OR…
Determinants of HIV outpatient service utilization according to HIV parameters
2014
Introduction : The increased life expectancy of HIV patients in the era of highly active antiretroviral therapy has had profound consequences for the healthcare systems that provide their care. It is useful to assess whether healthcare resources need to be adapted to the different stages of HIV infection or to patient characteristics [1]. To study how patient features influence utilization of out patient services, we retrospectively analyzed the electronic health record of HIV-positive patients who had followed day-care programs at the AIDS Center of the University of Palermo, Italy. Materials and Methods : 223 HIV-infected subjects were recruited and divided into two groups according to CD…
Public responses to intimate partner violence against women: the influence of perceived severity and personal responsibility.
2009
This paper explored public willingness to act when exposed to cases of intimate partner violence against women, by analyzing the influence of perceived severity and personal responsibility on two types of responses: mediating and reporting to the police. Results (N = 419) yielded main effects of personal responsibility for both types of responses. No main effects of perceived severity were found. A significant interaction between perceived severity and personal responsibility was found only for reporting responses. Results are discussed in light of the helping behavior research tradition. Implications for public education and advocacy programs are also considered. Marisol.lila@uv.es; Enriqu…
Evaluation of the effectiveness of drug prevention programs: Analysis of the international scientific production (2002–2011)
2015
s / Drug and Alcohol Dependence 146 (2015) e202–e284 e205 Oxytocin effects on human aggressive responding Joseph L. Alcorn, Nadeeka Dias, N. Rathnayaka, Joy Schmitz, C. Green, Scott D. Lane Department of Psychiatry & Behavioral Sciences, School of Medicine, Program in Neuroscience, Graduate School of Biomedical Sciences, University of Texas Health Science Center – Houston, Houston, TX, United States Aims: In the search for interventions aimed at improving the social functioning of individuals with substance use disorders (SUD), the neuropeptide oxytocin (OT) and the oxytonergic system may hold promise as an intervention strategy for promoting prosocial behaviors. Acute administration of OT …
Association study of affective disorders with genetic polymorphisms of monoamine oxidases
2000
Introduction: Monoamine oxidases (MAO) catalyze the oxidative deamination of monoamines like norepinephrine, serotonin and dopamine. The existing MAOs (A and B) have distinct although partially overlapping biological functions and distributions in the brain. MAO A is mainly expressed in catecholaminergic neurons. Thirty-fold differences in enzyme activity of MAO A can be found in cultured cells from different individuals suggesting a genetic determination of enzyme activity. Indeed, a point mutation in the coding region of the gene which creates a restriction site for Fnu4HI alters the activity. Moreover, the pharmacological inhibition of monoamine oxidase A activity is one of the most effe…
Scientific evaluation on substance abuse research through web of science over the 2008–2012 period
2015
s / Drug and Alcohol Dependence 156 (2015) e102–e182 e149 agonist treatment for opioid dependence utilized postpartum reproductive health care services and identify the prevalence rate and contraceptive methods of this population. Methods: Data on contraceptive use were collected around the time of the postpartum OB visit for participants in the MOTHER (MaternalOpioidTreatment:HumanExperimentalResearch) study for this secondary analysis. Results: Among the 175 MOTHER participants, data about contraceptivemethodwereonlyavailable for43% (n=76)of the sample andmany reported not attending their postpartumOBvisit. Among those with data, 45% of participants (n=34) reported not using any contracep…
Decision Making Impairment: A Shared Vulnerability in Obesity, Gambling Disorder and Substance Use Disorders?
2016
Introduction Addictions are associated with decision making impairments. The present study explores decision making in Substance use disorder (SUD), Gambling disorder (GD) and Obesity (OB) when assessed by Iowa Gambling Task (IGT) and compares them with healthy con- trols (HC). Methods For the aims of this study, 591 participants (194 HC, 178 GD, 113 OB, 106 SUD) were assessed according to DSM criteria, completed a sociodemographi c interview and con- ducted the IGT. Results SUD, GD and OB present impaired decision making when compared to the HC in the over- all task and task learning, however no differences are found for the overall performanc e inthe IGT among the clinical groups. Results…