Search results for "Acis"
showing 10 items of 199 documents
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
2021
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…
Discrimination, work and health in immigrant populations in Spain
2009
One of the most important social phenomena in the global context is the flow of immigration from developing countries, motivated by economic and employment related issues. Discrimination can be approached as a health risk factor within the immigrant population's working environment, especially for those immigrants at greater risk from social exclusion and marginalisation. The aim of this study is to research perceptions of discrimination and the specific relationship between discrimination in the workplace and health among Spain's immigrant population. A qualitative study was performed by means of 84 interviews and 12 focus groups held with immigrant workers in five cities in Spain receivin…
Perceived Racial/Ethnic Discrimination and Psychological Outcomes Among Adult International Adoptees in Finland: Moderating Effects of Social Support…
2015
Quantitative literature on international adoptees and racial/ethnic discrimination is lacking despite results in qualitative studies from Europe and the United States that have consistently indicated how racism constantly complicates adoptees' everyday lives. To advance the literature, the present study examined the prevalence of perceived racial/ethnic discrimination among 213 adult international adoptees in Finland (59.6% women and 40.4% men, mean age 24.1 years), and the association between perceived racial/ethnic discrimination and psychological well-being indicators, including psychological distress and sleeping problems. In addition, we examined social support and sense of coherence a…
Impact of pharmaceutical intervention on quality of life and coping strategies in patients with haematological malignancies
2015
Summary Objectives We conducted a prospective study approved by the local ethics committee to determine the impact of a pharmaceutical intervention (PI) on pain, fatigue, quality of life (QoL) and coping strategies in patients with HMs starting chemotherapy sessions. Material and methods Patients received either usual care (UC) + PI (PI group) or UC alone (UC group). They had to complete 2 questionnaires, QLQ-C30 and MAC 21, at 3 different time points: before starting the 1st chemotherapy session (T1), during the intercure (T2) and the day before starting the 2nd chemotherapy session (T3). To determine predictive factors of pain, fatigue, QoL and coping scores at T3, a multivariate ANOVA wa…
The role of the Community Pharmacist in promoting vaccinations among general population according to the National Vaccination Plan 2017-2019: results…
2019
Introduction. The 2017-2019 Italian National Vaccination Plan promotes the improvement of knowledge and attitudes of healthcare workers about vaccine prevention, in order to spread a vaccination culture among general population. Similarly to the General Practitioner, the Pharmacist represents a fundamental forefront for both patients and healthy people, also in promoting vaccine acceptance. This research aims to analyze knowledge and attitudes about vaccines of Community Pharmacists and to evaluate the burden of vaccination counselling during their work activities. Material and methods. A standardized, self-administered and previously validated questionnaire, including 5 sections and 28 ite…
Rasisms un noziegumi Voltera Moslija detektīvromānos "Velns zilā kleitā", "Sarkanā nāve" un "Balts tauriņš"
2019
Bakalauradarbs „Rasisms un kriminālsVolteraMoslijadetektīvromānos „Velnszilākleitā”, „Sarkanānāve” un „Baltstauriņš”” analizēnosauktus romānus ar uzsvaru uz aprakstītas kriminālas situācijas un rasismu ASV kopumā un Kalifornijā. Ņemot vērā ka romāni pieder pie daiļliteratūras un autora situācijas redzējums var atšķirties no reālas situācijas ASV četrdesmitajos un piecdesmitajos gados, ir savākta un apkopota informācija par rasisma un segregācijas vēsturi ASV, lai izprastu, cik patiess priekšstats par situāciju autors dod. Bakalaura darba mērķis ir atrast rasisma un segregācijas piemērus romānos; saprast, kā atrastie piemēri ilustrē rasisma, augstu ieslodzīto un apsūdzēto afroamerikāņu īpats…
Public Reason and the Limits of Liberal Anti-Racism in Latvia
2011
My paper is a critical analysis of anti-racist and tolerance promotion initiatives in Latvia. First, I trace the historical and geopolitical conditions that enable the emergence of two discursive positions that are central to arguments about racism - that of liberally inclined tolerance activists and that of Latvians with politically objectionable nationalist sensibilities. Subsequently, I argue that, plagued by developmentalist thinking, anti-racist and tolerance promotion initiatives fail in their analysis of contemporary racism. They posit backward attitudes as the main hindrance to the eradication of racism and displace racism as a constitutive feature of modern political forms onto ind…
Marie Baldwin, racism, and the society of American Indians
2020
The French/Ojibwa lawyer, activist, and Office of Indian Affairs employee, Marie Louise Bottineau Baldwin (1863–1952), often receives mention in scholarly works on the Society of American Indians (SAI). Very few, however, have examined her contributions in detail. Only one article focusing exclusively on Baldwin has ever been published. Cathleen D. Cahill’s flattering portrait depicts Baldwin as a devoted suffragette and leading SAI figure who, in her roles as cofounder and treasurer, promoted the cause of Indian rights and her own Ojibwa values concerning women’s equality. Cahill explains Baldwin’s sudden exit from the SAI as a result of attacks by male, anti-Indian Office “radicals” who c…
Type-IIA secreted phospholipase A2 is an endogenous antibiotic-like protein of the host.
2010
International audience; Type-IIA secreted phospholipase A(2) (sPLA(2)-IIA) has been proposed to play a role in the development of inflammatory diseases. It has been shown to release arachidonic acid, the precursor of proinflammatory eicosanoids, to hydrolyze phospholipids of pulmonary surfactant, and to bind to specific receptors located on cell surface membranes. However, the most established biological role of sPLA(2)-IIA is related to its potent bactericidal property in particular toward Gram-positive bacteria. This enzyme is present in animal and human biological fluids at concentrations sufficient to kill bacteria. Human recombinant sPLA(2)-IIA is able to kill Gram-positive bacteria at…
Relationship between carotid intima-media thickness and non valvular atrial fibrillation type.
2015
OBJECTIVE: Carotid intima-media thickness (cIMT) is a surrogate marker of subclinical atherosclerosis and it is able to predict both coronary and cerebral vascular events. No data exist on the association between cIMT and non valvular atrial fibrillation (NVAF) type. We conduct this study with the aim to analyze the association between abnormal cIMT and NVAF type. METHODS: A cross-sectional study of the "Atrial fibrillation Registry for Ankle-brachial index Prevalence Assessment-Collaborative Italian Study (ARAPACIS)" has been performed. Among 2027 patients enrolled in the ARAPACIS, 673 patients, who underwent carotid ultrasound examination to assess cIMT, were included in the study. RESULT…