6533b86dfe1ef96bd12c9f8d
RESEARCH PRODUCT
Relationship between carotid intima-media thickness and non valvular atrial fibrillation type.
Proietti MCalvieri CMalatino LSignorelli SCorazza GrPerticone FVestri ArLoffredo LDavì GVioli FBasili SArapacis (Atrial Fibrillation Registry For Ankle-brachial Index Prevalence Assessment-collaborative Italian Study) Study InvestigatorsAlessandri CServiddio GGreco EBruno GAverna MGiammanco ACominacini LMozzini CSprovieri MSpagnuolo VCerasola GMulé GBarbagallo MLo Sciuto SMonteverde ASaitta ALo Gullo AMalantino LCilia CPinto ADi Raimondo DSanto SMassimiliano AGaletti FFazio VDe Luca NArcangelo IBresciani AGiunta RCimini CDurante Mangoni EAgrusta FIorio VAdinolfi LeSellitto ARetivo LBellis PTirelli PVanni DPalazzuoli ARavallese FSantini CLetizia CPetramala LZinnamoscra LFalaschi PMartocchia AStefanelli MVincenzo MLo Iacono CBrusco SBertazzoni GAttalla El Halabieh EParadiso MLizzi Eugenio MTimmi SBattisti PCerci SDi Veroli CMalci FDe Ciocchis ACastellino PCurto IVecchio CMannarino EPasqualini LFattori CRicchio RFimognari FlAlletto MMessina SSesti GArturi FGrembiale APerticone FScarpino PeCarullo GFrugiuele PSpagnuolo VBattaglia GDi Michele DFava ABalsano CDe Ciantis PGiovambattista DCamerota AMezzetti MGresele PVedovati CFierro TPuccetti LScarpini FBoddi MSavino AContri SSaller AFabris FPesavento RFillippi LVedovetto VPuato MMinuz PCalabria SRomano SStockner IPattis PGutmann BCatena CColussi GCorazza GrMiceli EPadula DSchinco GSpreafico SSerra MgLongo SAntonaci SBelfiore AFrualdo MVentrella FLuigi ICesare BSantovito DCipollone FNicolai SSalvati FRini GbScozzari FMuiesan MlSalvetti MBazza APicardi ADe Vincentis AMadaffari BParasporo BGentili TSalvi ANitti CFalsetti LAndreozzi PEttorre EViscogliosi GRossi FfDelfino MGlorioso NMelis GMarras GMatta MSacco AStellitano EScordo APorreca ESantilli FTana MMuscianisi GSabbà CSuppressa PMancuso GBartone MCalipari DGiuseppe ABellanuova IFerraro MScalzo AMarigliano GCozzolino DLampitella AAcri VGalasso DMazzei FGalasso SBuratti APala MFabbian FManfredini RMoroni CValente LLopreiato FGentile ACatazzo VDi Napoli MBaciarello GRancan EAgeno WGuasti LCiccaglioni ANegri SPolselli MPrisco DPignataro FsPastori DFerro DLoffredo LCangemi RPerri LPolimeni LCatasca ERaparelli VNapoleone LSchillizzi MTalerico GCalvieri CAmoroso DVicario TRusso RGentile McCarboni ASaliola MDel Ben MAngelico FVestri ArFarcomeni ADi Tanna GDavi GBasili SMannucci PmPerticone FHiatt WVestri ArRoberto GLicata GVioli FGobbi PBasili SCorrao S.subject
Carotid Artery DiseasesMaleRegistrieSettore MED/09 - Medicina Internagenetic structuresCross-sectional studycarotid intima-media thickness; non valvular atrial fibrillation; ARAPACIScarotid atherosclerosisPredictive Value of TestComorbiditySubclinical atherosclerosiintima-media-thicknessCarotid intima-media thickneRisk FactorsAtrial Fibrillation80 and overPrevalencenonvalvular atrial fibrillation; intima-media-thickness; carotid atherosclerosisRegistriesCarotid intima-media thicknessStrokeAged 80 and overCarotid intima-media thickness; Paroxysmal non valvular atrial fibrillation; Persistent/permanent non valvular atrial fibrillation; Subclinical atherosclerosis; Aged; Aged 80 and over; Ankle Brachial Index; Asymptomatic Diseases; Atrial Fibrillation; Carotid Artery Diseases; Carotid Artery Common; Chi-Square Distribution; Comorbidity; Cross-Sectional Studies; Female; Humans; Italy; Linear Models; Logistic Models; Male; Middle Aged; Predictive Value of Tests; Prevalence; Registries; Risk Factors; Carotid Intima-Media ThicknessMedicine (all)Atrial fibrillationMiddle AgedCommonItalyPredictive value of testsnon valvular atrial fibrillationCardiologycardiovascular systemLinear ModelFemaleCardiology and Cardiovascular MedicineHumanmedicine.medical_specialtyLogistic ModelCarotid Artery CommonPersistent/permanent non valvular atrial fibrillationparoxysmal non valvular atrial fibrillation; persistent/permanent non valvular atrial fibrillation; subclinical atherosclerosis; carotid intima-media thicknessPredictive Value of TestsParoxysmal non valvular atrial fibrillationInternal medicinemedicineHumansAnkle Brachial Indexcardiovascular diseasesSubclinical atherosclerosisCarotid intima-media thickness; Paroxysmal non valvular atrial fibrillation; Persistent/permanent non valvular atrial fibrillation; Subclinical atherosclerosisAgedCross-Sectional StudieAsymptomatic DiseaseCarotid Artery DiseaseChi-Square Distributionbusiness.industrySurrogate endpointRisk Factornonvalvular atrial fibrillationmedicine.diseaseSettore MED/11 - Malattie Dell'Apparato CardiovascolareComorbidityParoxysmal Non Valvular Atrial Fibrillation Persistent/Permanent Non Valvular Atrial Fibrillation Subclinical Atherosclerosis Carotid Intima-Media ThicknessCross-Sectional StudiesLogistic ModelsIntima-media thicknessAsymptomatic DiseasesLinear ModelsARAPACISCarotid ArterybusinessChi-squared distributiondescription
OBJECTIVE: Carotid intima-media thickness (cIMT) is a surrogate marker of subclinical atherosclerosis and it is able to predict both coronary and cerebral vascular events. No data exist on the association between cIMT and non valvular atrial fibrillation (NVAF) type. We conduct this study with the aim to analyze the association between abnormal cIMT and NVAF type. METHODS: A cross-sectional study of the "Atrial fibrillation Registry for Ankle-brachial index Prevalence Assessment-Collaborative Italian Study (ARAPACIS)" has been performed. Among 2027 patients enrolled in the ARAPACIS, 673 patients, who underwent carotid ultrasound examination to assess cIMT, were included in the study. RESULTS: Among the entire population, 478 patients (71%) had cIMT > 0.90 mm. Patients with an abnormal cIMT (>0.90 mm) were significantly older and more likely hypertensive, diabetic and with a previous history of stroke than those with normal cIMT (≤0.90 mm). These patients had more permanent/persistent NVAF and CHA2DS2-VASc score ≥ 2 (p < 0.0001) compared to those with cIMT <0.90 mm. Excluding all patients affected by previous cardiovascular disease, logistic regression analysis showed that independent predictors of abnormal cIMT were: age class 65-74 yrs. (p < 0.001), age class ≥75 yrs. (p < 0.001), arterial hypertension (p < 0.001), calcium-channel blockers use (p < 0.001) and persistent/permanent NVAF (p = 0.001). CONCLUSION: Our findings show a high prevalence of abnormal cIMT in NVAF patients, reinforcing the concept that NVAF and systemic atherosclerosis are closely associated. Abnormal cIMT was particularly evident in persistent/permanent NVAF suggesting a more elevated atherosclerotic burden in patients with long-standing NVAF. TRIAL REGISTRATION: http://clinicaltrials.gov/ct2/show/NCT01161251.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 |