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showing 10 items of 2898 documents
Proteins in Ionic Liquids: Reactions, Applications, and Futures
2019
Biopolymer processing and handling is greatly facilitated by the use of ionic liquids, given the increased solubility, and in some cases, structural stability imparted to these molecules. Focussing on proteins, we highlight here not just the key drivers behind protein-ionic liquid interactions that facilitate these functionalities, but address relevant current and potential applications of protein-ionic liquid interactions, including areas of future interest.
Global Real-World Evidence of Sofosbuvir/Velpatasvir as a Highly Effective Treatment and Elimination Tool in People with Hepatitis C Infection Experi…
2022
HCV elimination; Mental health disorders; Sofosbuvir/velpatasvir Eliminación del VHC; Trastornos de salud mental; Sofosbuvir/velpatasvir Eliminació del VHC; Trastorns de salut mental; Sofosbuvir/velpatasvir Hepatitis C virus (HCV) is prevalent in people with mental health disorders, a priority population to diagnose and cure in order to achieve HCV elimination. This integrated analysis pooled data from 20 cohorts in seven countries to evaluate the real-world effectiveness of the pangenotypic direct-acting antiviral (DAA) sofosbuvir/velpatasvir (SOF/VEL) in people with mental health disorders. HCV-infected patients diagnosed with mental health disorders who were treated with SOF/VEL for 12 w…
Measuring, comparing and interpreting phenotypic selection on floral scent
2022
Natural selection on floral scent composition is a key element of the hypothesis that pollinators and other floral visitors drive scent evolution. The measure of such selection is complicated by the high-dimensional nature of floral scent data and uncertainty about the cognitive processes involved in scent-mediated communication. We use dimension reduction through reduced-rank regression to jointly estimate a scent composite trait under selection and the strength of selection acting on this trait. To assess and compare variation in selection on scent across species, time and space, we reanalyse 22 datasets on six species from four previous studies. The results agreed qualitatively with prev…
Giuseppe Cocchiara, il fascismo e il razzismo
2021
In questo saggio viene ricostruito il rapporto tra Giuseppe Cocchiara e il fascismo. L’antropologo visse in pieno la sua formazione culturale all'interno del regime al quale aderì con convinzione e slancio, militando sempre nelle sue fazioni più radicali, condividendone fedelmente le scelte più tragiche come la guerra d’Etiopia, sottoscrivendo le leggi razziali, impegnandosi nella seconda guerra mondiale con le armi culturali dell’antisemitismo e della lotta senza tregua contro la democrazia. Così quando, come in un «mondo alla rovescia», sconfitto il fascismo sotto il peso di un’umiliante e sanguinosa disfatta, saranno proprio gli odiati inglesi a valorizzarne la statura intellettuale e la…
Mineral Reactions in the Geological Underground Induced by H2 and CO2 Injections
2014
Abstract The R&D project H2STORE is part of the German program to reduce environmental pollution by energy production and in saving fossil natural resources. Thereby physico-chemical processes in the CO2-H2 system by organic and inorganic reactions receive increasing attention. In H2STORE siliciclastic reservoirs and their caprocks from 25 well sites in Germany and Austria are investigated by different analytical methods before and after H2/CO2 batch experiments under sample specific reservoir conditions (p, T, XFluid). Mineral dissolution, precipitation and their impact on reservoir quality (poro-perm, fluid pathways) and on the generation of methane by microbial metabolism triggered by CO…
Le menu au restaurant : construction pragmatique de l’expérience gastronomique et enjeux identitaires
2014
International audience; Ce travail de recherche, ancré dans le champ de l’analyse conversationnelle (Sacks, 1992), est basé sur un corpus d’enregistrements vidéo réalisé en contexte naturel de production dans plusieurs restaurants de type gastronomique en France. Les données collectées sont transcrites finement afin de rendre compte des ressources linguistiques et multimodales (Mondada, 2008) mobilisées par les participants à l’interaction.Dans notre corpus, nous avons constaté que le menu est un objet important dans l’organisation du service au restaurant et qu’il est utilisé à différentes fins pratiques selon les séquences d’activités et selon les participants qui l’utilisent (personnels …
Le menu au restaurant : textualité, oralité et usages en interaction.
2012
International audience; Ce travail de recherche, ancré dans le champ de l’analyse conversationnelle (Sacks, 1992), est basé sur un corpus d’enregistrements vidéo réalisé en contexte naturel de production dans plusieurs restaurants de type gastronomique en France. Les données collectées sont transcrites finement afin de rendre compte des ressources linguistiques et multimodales (Mondada, 2008) mobilisées par les participants à l’interaction.Dans notre corpus, nous avons constaté que le menu est un objet important dans l’organisation du service au restaurant et qu’il est utilisé à différentes fins pratiques selon les séquences d’activités et selon les participants qui l’utilisent (personnels …
Regulation of immune response in post-operative endophthalmitis
2011
Regulation of immune response in post-operative endophthalmitis. annual meeting of the association-for-research-in-vision-and-ophthalmology (ARVO)
Inhibition of small G proteins of the Rho family by statins orClostridium difficiletoxin B enhances cytokine-mediated induction of NO synthase II
2000
In order to investigate the involvement of Ras and/or Rho proteins in the induction of the inducible isoform of nitric oxide synthase (NOS II) we used HMG-CoA reductase inhibitors (statins) and Clostridium difficile toxin B (TcdB) as pharmacological tools. Statins indirectly inhibit small G proteins by preventing their essential farnesylation (Ras) and/or geranylgeranylation (Rho). In contrast, TcdB is a glucosyltransferase and inactivates Rho-proteins directly. Human A549/8- and DLD-1 cells as well as murine 3T3 fibroblasts were preincubated for 18 h with statins (1–100 μM) or TcdB (0.01–10 ng ml−1). Then NOS II expression was induced by cytokines. NOS II mRNA was measured after 4–8 h by R…
The Influence of Nanoparticle Shape on Protein Corona Formation
2020
Nanoparticles have become an important utility in many areas of medical treatment such as targeted drug and treatment delivery as well as imaging and diagnostics. These advances require a complete understanding of nanoparticles' fate once placed in the body. Upon exposure to blood, proteins adsorb onto the nanoparticles surface and form a protein corona, which determines the particles' biological fate. This study reports on the protein corona formation from blood serum and plasma on spherical and rod‐shaped nanoparticles. These two types of mesoporous silica nanoparticles have identical chemistry, porosity, surface potential, and size in the y ‐dimension, one being a sphere and the other a …