Search results for "Active"

In Vitro Cytotoxic Effect of Aqueous Extracts from Leaves and Rhizomes of the Seagrass Posidonia oceanica (L.) Delile on HepG2 Liver Cancer Cells: Fo…

2023

Aqueous extracts from Posidonia oceanica’s green and brown (beached) leaves and rhizomes were prepared, submitted to phenolic compound and proteomic analysis, and examined for their potential cytotoxic effect on HepG2 liver cancer cells in culture. The chosen endpoints related to survival and death were cell viability and locomotory behavior, cell-cycle analysis, apoptosis and autophagy, mitochondrial membrane polarization, and cell redox state. Here, we show that 24 h exposure to both green-leaf- and rhizome-derived extracts decreased tumor cell number in a dose–response manner, with a mean half maximal inhibitory concentration (IC50) estimated at 83 and 11.5 μg of dry extract/mL, respecti…

Observe while it happens : catching photoactive proteins in the act with non-adiabatic molecular dynamics simulations

2020

Organisms use photo-receptors to react to light. The first step is usually the absorption of a photon by a prosthetic group embedded inside the photo-receptor, often a conjugated chromophore. The electronic changes in the chromophore induced by photo-absorption can trigger a cascade of structural or chemical transformations that culminate into a response to light. Understanding how these proteins have evolved to mediate their activation process has remained challenging because the required time and spacial resolutions are notoriously difficult to achieve experimentally. Therefore, mechanistic insights into photoreceptor activation have been predominantly obtained with computer simulations. …

Binary Materials TiO2 or ZnO-Activated Carbon Used as Photomediators in the Photocatalytic Degradation of 2-Propanol in Gas-Solid Regime

2010

Modulation of Efficient Diiodo-BODIPY in vitro Phototoxicity to Cancer Cells by Carbon Nano-Onions

2020

Photodynamic therapy (PDT) is currently one of the most promising approaches for targeted cancer treatment. It is based on responses of vital physiological signals, namely reactive oxygen species (ROS), which are associated with diseased condition development, such as tumors. This study presents the synthesis, incorporation, and application of a diiodo-BODIPY based photosensitizer, based on a non-covalent functionalization of carbon nano-onions (CNOs). In vitro assays demonstrate that HeLa cells internalize the diiodo-BODIPY molecules, and their CNOs nanohybrids. Upon cell internalization and light exposure, the pyrene-diiodo-BODIPY molecules induce an increase of the ROS level of HeLa cell…

Environmental Aspect Concerning Phthalates Contamination: Analytical Approaches and Assessment of Biomonitoring in the Aquatic Environment

2023

This review is a survey of recent progress in studies concerning the impact of phthalic acid esters in aquatic organisms. After introducing the classification, properties, sources, fate, and toxic effects related to phthalates, an overview of the techniques of extraction and analysis of these substances is provided. As a result, the general concepts of environmental bioindicators, biomonitoring systems, and other concepts related to phthalate contamination in the aquatic environment are presented. Recent bioaccumulation data of different phthalates are summarised in a table and organised according to the type of organism, tissue, and geographical area of sampling. Bioindicator organisms tha…

Effect of Sex, Body Mass Index and Physical Activity Level on Peak Oxygen Uptake Among 14–19 Years Old Adolescents

2020

The aim was to describe longitudinal trends in peak oxygen uptake (VO2peak) among 14- to 19-year-old adolescents in Norway, and to examine effects of sex, body mass index (BMI), and physical activity (PA) level on VO2peak during adolescence. Of 124 invited students from two lower secondary schools in Norway, 116 eighth-grade students (61 boys and 55 girls; 14 years old at baseline) volunteered to participate. The study has a longitudinal design with 6 yearly repeated measures of body height and mass, VO2peak and PA level. VO2peak allometrically scaled to body mass raised to the power of 0.67 was measured using a walking or running incremental test on a treadmill, whereas PA level was self-r…

Vauhtia elinvuosiin liikunnalla : entä lisää elinvuosia?

2018

Havainnoivien seurantatutkimusten mukaan runsas vapaa-ajan liikunnanharrastus on yhteydessä alempaan ennenaikaisen kuoleman riskiin. Syy-seuraus -suhdetta ei kuitenkaan ole pystytty varmistamaan satunnaistetuissa kontrolloiduissa interventiotutkimuksissa. Monia muita terveyshyötyjä – kuten vaikutukset fyysiseen suorituskykyyn ja kehon koostumukseen – on näin pystytty varmistamaan. Niitä kannattaakin käyttää perusteena mieluummin kuin mahdollista vaikutusta eliniän pituuteen, kun liikuntaa markkinoidaan terveyshyödyillä. nonPeerReviewed

Assessment of Physical and Chemical Stability of Different Magnesium Compounds in Tablets

2020

Modern lifestyle, excessive chemicalization of agricultural products, excessive processing and refining of food, cause a decrease in daily intake of magnesium, cation with an extremely important role in prevention and treatment of many diseases. As a result, there arises the need for extra magnesium intake in the form of dietary supplements. In this study were evaluated the physical and chemical stability of magnesium-containing tablets, depending on the active compound and the excipients used. Magnesium tablets in the form of orotate, lactate, citrate, oxide and hydroxide were taken into study and physical and chemical stability were observed over the validity period, at 6 and at 12 month…

The Influence of Contextual Aspects in Talent Development: Interaction Between Relative Age and Birthplace Effects in NBA-Drafted Players

2021

The aims of this study were two-fold: (1) to inspect separately for the relative age and birthplace effects for players selected in the National Basketball Association (NBA) draft; (2) to explore the interaction among these factors and analyse this interaction in players' career performance. The database was obtained from the official records of the players (n = 1,738), who were selected during the annual editions of the NBA Draft from 1990 to 2019. The participants' date of birth was analyzed according to the month of birth and divided into four quartiles. The place of birth was compared to the distribution of the general population' places of birth based on different communities' sizes. C…

Servicios Sociales, derechos de ciudadanía y atención centrada en la persona

2011

Tras treinta años de implantación y desarrollo de los servicios sociales en España, nos encontramos en un momento trascendental para el futuro de este sistema, donde los servicios sociales pueden salir de la situación de fragilidad actual, y convertirse en un sistema similar al sanitario o educativo, basado en normas que establecen derechos subjetivos. Por otro lado, la paulatina incorporación de la cultura de la calidad y los nuevos conceptos de calidad de vida, junto con la consideración de estos servicios como de interés general pueden hacer que los servicios sociales del siglo XXI, desplieguen un mayor protagonismo en una situación de crisis económica como la actual, con un papel más re…