Search results for "Activity"

Structure-activity relationships of dimethindene derivatives as new M2-selective muscarinic receptor antagonists.

2003

A series of 2,3-disubstituted indenes, which are analogues of the widely used histamine H(1) receptor antagonist dimethindene, have been synthesized and studied as muscarinic and histamine receptor antagonists. The affinities of these compounds for the five human muscarinic receptor subtypes (M(1)-M(5)) and for human histamine H(1) receptors were determined in radioligand binding studies using membranes from transfected Chinese hamster ovary (CHO) cells and [(3)H]N-methylscopolamine ([(3)H]NMS). The results demonstrate that the diisopropyl analogue 19 has a similar high affinity as (S)-dimethindene at M(2) receptors ((S)-dimethindene: pK(i) = 7.52; (-)-19: pK(i) = 7.37) with an improved sel…

Associations of muscular fitness and body composition in children

2021

Purpose: To examine the associations between muscular fitness (MF) and body composition. Method: MF was assessed with three tests of FitnessGram test battery. Total body fat percentage (BF%), abdominal fat percentage (AF%) and fat-free mass (FFM) were measured by dual-energy X-ray absorptiometry (DXA). The IOTF body mass index (BMI) cut-offs were used to define healthy weight, overweight, and obesity. Results: MF was inversely associated with BF% and AF%. The children in the moderate and high MF groups had significantly lower BF% and AF% compared with the children in the low MF group within the same BMI category. After adjusting for cardiorespiratory fitness (CRF), BMI and sex, the differen…

Evaluation of anti-androgenic activity of di-(2-ethylhexyl)phthalate

2005

International audience; DEHP is a widely used platiciser in the manufacture of PVC-based materials. It is known to disrupt the reproductive tract development in male rats. We have performed the Hershberger assay with DEHP on an immature castrated rat model to check if DEHP antagonise the testosterone propionate androgenic effect on the accessory sex organs development. DEHP significantly decreased the BC/LA muscles, the prostate, and the seminal vesicles relative weights from 100, 200, and 400 mg/kg bw/day, respectively. DEHP increased the liver relative weight from 100 mg/kg bw/day. A study was also performed on MDA-MB453 cell line stably transfected with pMMTVneo-Luc with DEHP and its maj…

Lack of effects of anabolic-androgenic steroids on locomotor activity in intact male mice.

1999

Anabolic-androgenic steroid abusers have reported hyperactivity euphoria, and decreased fatigue, among other behavioral effects. It has been suggested that the effects of these substances on the central nervous system are similar to those of psychostimulants; however, the influence of steroids on general locomotor activity in laboratory animals is not well understood, especially how noncastrated male rodents are affected. In this study, spontaneous locomotor activity displayed by gonadally intact male mice submitted to several experimental conditions was analyzed. Different housing conditions (individual or cohabiting with a female), diverse steroids (testosterone propionate, nandrolone de…

Ionic liquid binary mixtures: How different factors contribute to determine their effect on the reactivity

2016

We studied how mixing ionic liquids affected the rate of the Diels Alder reaction between 9-anthracenemethanol and N-ethylmaleimide. The mixtures considered spanned the whole compositional range and differed for the anion or the cation. These comprised mixtures of the ionic liquid 1-benzyl-3-butyl-imidazolium bis-(trifluoromethanesulfonyl)imide ([Bzbim][NTf2]) with 1-(2,3,4,5,6-pentafluorophenyl)-3-butyl-imidazolium bis-(trifluoromethanesulfonyl)imide ([Bz(F5)bim][NTf2]) or 1-benzyl-3-butyl-imidazolium tetrafluoroborate ([Bzbim][BF4]). Moreover we studied the reaction in a set of mixtures containing an aliphatic and an aromatic cation, namely [Bzbim+] and N-butyltriethylammonium ([bEt3N+]) …

Phytochemical composition, anti-inflammatory and antitumour activities of four Teucrium essential oils from Greece

2009

Abstract The essential oils of four Teucrium species were studied and 150 components, in all, were identified. All oils were rich in sesquiterpenes (50.1–55.8%). Spathulenol and δ-cadinene were the main compounds of Teucrium brevifolium oil; caryophyllene and 4-vinyl guaiacol predominated in Teucrium flavum . Carvacrol and caryophyllene oxide predominated in Teucrium montbretii ssp. heliotropiifolium , while carvacrol and caryophyllene were the most abundant components in Teucrium polium ssp. capitatum . The oil which most effectively inhibited LPS-induced NO production in macrophage cell line RAW 264.7 was that from T. brevifolium (IC 50  = 7.1 μg/ml), followed by T. montbretii ssp. heliot…

Sports activities in the natural environment: its representation in physical education textbooks in primary school

2017

El objeto de esta investigación es analizar las actividades deportivas realizadas en el medio natural representadas en los libros de texto de Educación Física (EF) en la etapa de Educación Primaria (EP), publicados en la Ley Orgánica 2/2006, de 3 de mayo, de Educación (LOE). Se analizan 4339 imágenes, recogidas en 44 libros de texto, pertenecientes a ocho editoriales españolas. Para el análisis de contenido de las imágenes se utilizó la herramienta SAIMEF (Sistema de Análisis de las Imágenes de Educación Física), elaborada ad hoc. La prueba piloto, el panel de expertos y la triangulación con varios observadores fueron algunos de los criterios de cientificidad que avalaron dicha herramienta.…

Senti chi parla. Su un aspetto dell’attività di parola a partire da Lacan.

2017

MAD+. Introducing Misconceptions in the Temporal Analysis of the Mathematical Modelling Process of a Fermi Problem

2021

This work describes how the combination of the mistakes committed by a group of pre-service teachers when solving a Fermi problem, with the representation of the temporal analysis of their resolutions, can offer more in-depth information about their conceptual misconceptions regarding mathematical and modelling concepts. The combined representation allows knowing when mistakes occur and provides a powerful tool for instructors to adapt the teaching–learning processes of mathematics at all levels of education. Our study is based on a recent categorisation of students’ mistakes, together with the creation of a new representation tool, called MAD+, that can combine all this information. The ma…

Reactivity of cellulose during hydrothermal carbonization of lignocellulosic biomass

2020

Abstract Hydrothermal carbonization (HTC) of pure cellulose (CE) and birchwood (BW) samples was carried out at temperatures between 160 and 280 °C, 0.5 h residence time and biomass-to-water ratio 1:5, to investigate the reactivity of cellulose in lignocellulosic biomass. Thermogravimetric analysis (TGA) and Fourier transform infrared spectroscopy (FTIR) showed that the CE samples remained unaltered at temperatures up to 220 °C, but were significantly decomposed at 230 °C producing a thermal recalcitrant aromatic and high energy-dense material. FTIR showed that dehydration and aromatization reactions occurred at temperature equal or higher than 230 °C for the CE samples while a similar incre…