Search results for "Activity"
showing 10 items of 7178 documents
Behaviour of cyclic bank voles under risk of mustelid predation: do females avoid copulations?
1993
Mustelid odours have been shown to suppress breeding in captive bank voles (Clethrionomys glareolus) from cyclic populations (Ylonen 1989; Ylonen and Ronkainen 1994). The mechanism behind the suppression is unknown. Based on a series of behavioural trials and breeding experiments with pairs of bank voles in breeding condition, we suggest that the primary cause for breeding suppression is a change in female mating behaviour. Experimental female-male pairs (n=34) exposed to mustelid odour decreased their general activity compared to control pairs (n=34). When encountering males in behavioural trials, females exposed to stoat odour were more aggressive and actively avoided precopulatory behavi…
Trait Emotional Intelligence, Self-Reported Affect, and Salivary Alpha-Amylase on Working Days and a Non-Working Day
2017
This study examined the relationship between trait emotional intelligence (EI) and variation in psychological (positive affect: PA, negative affect: NA) and psychophysiological (salivary alpha-amylase: sAA) indicators among Japanese employees over 3 consecutive days (working day 1, non-working day, working day 2). The analyses revealed that higher trait EI was associated across the days with higher PA, but not with NA. Moreover, diurnal sAA levels were lower in the high trait EI group than in the low trait EI group on the intervening non-working day, and this difference between the EI groups continued to show a tendency to significance on working day 2. The results indicate that higher EI m…
Quantification of HSP27 and HSP70 Molecular Chaperone Activities
2011
Stress-inducible heat-shock proteins (HSPs, like HSP70 and HSP27) are molecular chaperones that -protect cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. HSP27 and HSP70 chaperone activities are useful indicators to test chemical products and physical stress impact on protein denaturation, to select HSP inhibitors, or to -determine the implication of the chaperone function in other HSP activities, such as apoptosis. We have developed two simple and fast chaperone activity tests for HSP27 and HSP70 that we initially set up to test the effect of potential HSP inhibitors obtained after screening of chemical an…
Modulation of protein phosphorylation by natural products
2002
Studies carried out to determine the influence of phosphorylation and dephosphorylation of proteins in a variety of physiological events are of increasing interest. The activity of kinases and phosphatases and their respective inhibition by endogenous mediators and by pharmacological agents regulates a huge number of biochemical pathways involved in cellular proliferation, apoptosis, inflammation, hormonal activity, and gene transcription, amongother processes. This article focuses on the recently described natural products able to interfere negatively with the activity of serine/threonine and tyrosine kinases. These agents are classified, according to theirbiosynthetic origin and chemical …
Theoretical studies of HIV-1 reverse transcriptase inhibition
2012
Computational methods for accurately calculating the binding affinity of a ligand for a protein play a pivotal role in rational drug design. We herein present a theoretical study of the binding of five different ligands to one of the proteins responsible for the human immunodeficiency virus type 1 (HIV-1) cycle replication; the HIV-1 reverse transcriptase (RT). Two types of approaches are used based on molecular dynamics (MD) simulations within hybrid QM/MM potentials: the alchemical free energy perturbation method, FEP, and the pathway method, in which the ligand is physically pulled away from the binding site, thus rendering a potential of mean force (PMF) for the binding process. Our com…
Herbicidal activity of derivatives of 9-aminofluoren-9-ylphosphonic acid
1991
A series of derivatives of 9‐aminofluoren‐9‐ylphosphonic acid (phosphonic analogues of morphactins) were synthesized and screened for herbicidal activity against Lepidium sativum, Cucumis sativus and Lycopersicon esculentum. Ethyl 9‐(N‐alkylamino)fluoren‐9‐yl(phenyl)phosphinates appeared to be equipotent with glyphosate and thus may be recognized as new lead compounds for further structural modifications.
Composition and Antimicrobial Activity of Essential Oil ofAnthemis tenuisectaBall
2007
Abstract The Chemical composition of the essential oil of Anthemis tenuisecta Ball. (Anthemideae) was analyzed by gas Chromatography-mass spectrometry (GC-MS). Forty eight components accounting for 89.5 % of the oil were identified, being camphor (17.5 %), 6-methyl-5-hepten-2-one (17.1 %), borneol (11.5 %), sesquicineole (11%) and camphene (5.7 %) the main compounds. In the antibacterial diffusion assay, the oil showed activity against Gram-positive bacteria.
Composition and Antibacterial Activity of Essential Oils ofCladanthus arabicusCass. (Asteraceae)
2005
Abstract The chemical composition of the essential oils of the aerial parts (stems and leaves: sample A) and flowers (sample B) of Cladanthus arabicus Cass., were analysed by GC-MS. Monoterpenes hydrocarbons constituted the main chemical group in both essential oils, with Sabinene, β-pinene, α-pinene, myrcene, α-phellandrene and p-cymene as the main compounds. Sample A was tested for its antimicrobial activity against six Gram positive and negative bacteria. Results showed that the oil exhibited a significant antibacterial activity.
Investigations on the phosphoenolpyruvate carboxylase activity of spruce needles relative to the occurrence of novel forest decline
1991
Summary Investigations were carried out on phosphoenolpyruvate carboxylase (PEPC) activity in needles of Norway spruce trees [ Picea abies (L.) Karst.] at two natural sites during the course of three vegetation periods. PEPC activity found in needles of damaged trees was considerably higher than in needles of undamaged trees. Annual average figures varied up to 100%. The positive correlation between PEPC activity and the extent of damage of the investigated needles indicates a significant relationship between both parameters: the PEPC activity in spruce needles seems to be not only a qualitative, but also a quantitative indicator of the extent of damage. Higher PEPC activity in needles of d…
Towards a new treatment against polymicrobial infections: high antibacterial activity of lemon IntegroPectin against Pseudomonas aeruginosa and Esche…
2020
AbstractLemon IntegroPectin obtained via hydrodynamic cavitation of waste lemon peel in water only shows high antibacterial activity against two Gram-negative bacteria, Pseudomonas aeruginosa and Escherichia coli. The antibacterial effect against the ubiquitous pathogen P. aeruginosa was evaluated in terms of the minimal bactericidal (MBC) and minimal inhibitory concentration (MIC). Preliminary insight on the antibacterial mechanism of IntegroPectin originates from investigating its inhibitory activity against E. coli. Given the non-cytotoxic nature of citrus IntegroPectin and the ease of its reproducible production in large amounts, the route is open to the industrial development of a new …