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showing 10 items of 19159 documents

Stem Cell Therapy

2019

The necessity of improving the health and quality of life of subjects affected by diverse injuries and chronic diseases, has led to develop a new branch of translational medicine, called Regenerative Medicine (RegMed). RegMed has the principal objects of restoring, maintaining or enhancing structures and functions of tissues and organs. In order to achieve these goals, the RegMed researchers have proposed and tested diverse approaches. The Stem Cell Therapy represents the central focus of RegMed, even if its applications may imply the onset of adverse conditions. Here, an overview of this topic will be reported, by pointing advantages and disadvantages.

mesenchymal stem cellsbusiness.industrymedicine.medical_treatmentfibrosisregenerative medicineStem-cell therapybenefits and limitationsstem cell therapyangiogenesistranslational medicinegrowth factors/cytokinesCancer researchSettore MED/05 - Patologia ClinicaMedicinebusinessangiogenesis; benefits and limitations; fibrosis; growth factors/cytokines; mesenchymal stem cells; regenerative medicine; stem cell therapy; translational medicine
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Chronic Mesenteric Ischemia: Critical review and guidelines for management

2011

Background CMI is caused by chronic occlusive disease of mesenteric arteries. In such an uncommon disease, clear recommendations are strongly needed. Unfortunately, treatment options for symptomatic CMI are still controversial and no guidelines exist. Methods A systematic literature review of the last 25-years was conducted through MEDLINE, Embase, and Cochrane Review/Trials register to identify studies reporting on CMI treatment with more than 10 patients. Primary outcomes were perioperative mortality and morbidity rates. Secondary outcomes were survival rates, primary and secondary patency rates, vessels treated, CMI recurrence, follow-up (FU), technical success (TS), and in-hospital leng…

mesenteric chronic ischemia vascular surgeryPediatricsmedicine.medical_specialtyTime FactorsMEDLINE610 Medicine & healthDiseaseSettore MED/22 - Chirurgia Vascolare2705 Cardiology and Cardiovascular MedicineIschemiaRecurrenceRisk FactorsMesenteric Vascular OcclusionmedicineHumansVascular PatencyVascular DiseasesSurvival rateVascular PatencyChi-Square Distributionbusiness.industry10042 Clinic for Diagnostic and Interventional RadiologyPatient Selection10031 Clinic for AngiologyEndovascular ProceduresGeneral MedicinePerioperativeLength of Staymedicine.disease10020 Clinic for Cardiac Surgery2746 SurgeryTreatment OutcomeSystematic reviewMesenteric ischemiaMesenteric IschemiaPractice Guidelines as TopicSurgeryCardiology and Cardiovascular MedicinebusinessVascular Surgical ProceduresChi-squared distributionAlgorithms
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Observation of the rare decay K-S -> pi(0)e(+)e(-)

2003

A search for the decay Ks->pi0e+e- has been made by the NA48/1 experiment at the CERN SPS accelerator. Using data collected during 89 days in 2002 with a high-intensity Ks beam, 7 events were found with a background of 0.15 events. The branching fraction BR(Ks->pi0e+e-, m(ee) > 0.165 GeV/c^2) = (3.0^{+1.5}_{-1.2}(stat) +/-0.2 (syst)) x 10^{-9} has been measured. Using a vector matrix element and a form factor equal to one, the measurement gives BR(Ks->pi0e+e-) = (5.8^{+2.9}_{-2.4}) x 10^{-9}.

mesoni K; decadimenti rariPhysicsNuclear and High Energy Physics010308 nuclear & particles physicsBranching fractionK-LForm factor (quantum field theory)Analytical chemistryKAON DECAYS01 natural sciences3. Good healthHigh Energy Physics - Experimentmesoni Kdecadimenti rariCP VIOLATION; KAON DECAYS; K-L; SEARCHSEARCH0103 physical sciencesMatrix elementCP VIOLATIONAtomic physics010306 general physics
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Physical activity reduces the risk of pneumonia : systematic review and meta-analysis of 10 prospective studies involving 1,044,492 participants

2022

The beneficial effects of regular physical activity in promoting health and preventing chronic diseases are well documented. The relationship between regular physical activity and the risk of pneumonia is uncertain. We aimed to evaluate the magnitude and specificity of the prospective association between regular physical activity and the risk of pneumonia using a systematic review and meta-analysis of published observational cohort studies in general populations. Relevant studies with at least 1 year of follow-up were sought from inception until 15 September 2021 in MEDLINE, Embase, Web of Science, and manual search of relevant articles. Relative risks (RRs) with 95% confidence intervals (C…

meta-analysisrisk factorsystematic reviewmeta-analyysicohort studyphysical activitypneumoniariskitekijätkohorttitutkimuskeuhkokuumesystemaattiset kirjallisuuskatsauksetfyysinen aktiivisuus
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Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.

2012

Expansion of CAG repeats is a common feature of various neurodegenerative disorders, including Huntington's disease. Here we show that expanded CAG repeats bind to a translation regulatory protein complex containing MID1, protein phosphatase 2A and 40S ribosomal S6 kinase. Binding of the MID1-protein phosphatase 2A protein complex increases with CAG repeat size and stimulates translation of the CAG repeat expansion containing messenger RNA in a MID1-, protein phosphatase 2A- and mammalian target of rapamycin-dependent manner. Our data indicate that pathological CAG repeat expansions upregulate protein translation leading to an overproduction of aberrant protein and suggest that the MID1-com…

metabolism [Microtubule Proteins]General Physics and AstronomyHTT protein humanRibosomal s6 kinaseMice0302 clinical medicinemetabolism [Transcription Factors]Protein Phosphatase 2Luciferasesgenetics [Nerve Tissue Proteins]genetics [Protein Biosynthesis]0303 health sciencesHuntingtin ProteinMultidisciplinarybiologyTOR Serine-Threonine KinasesNuclear ProteinsTranslation (biology)3. Good healthmetabolism [Luciferases]Microtubule Proteinsddc:500metabolism [Nuclear Proteins]genetics [Trinucleotide Repeat Expansion]Protein Bindingcongenital hereditary and neonatal diseases and abnormalitiesMTOR protein humanUbiquitin-Protein LigasesBlotting WesternNerve Tissue Proteinsmetabolism [TOR Serine-Threonine Kinases]metabolism [RNA Messenger]General Biochemistry Genetics and Molecular Biology03 medical and health sciencesgenetics [RNA Messenger]mental disordersHuntingtin ProteinAnimalsHumansEukaryotic Small Ribosomal SubunitRNA MessengerNucleotide Motifs030304 developmental biologyMessenger RNAmetabolism [Nerve Tissue Proteins]RNAmetabolism [Protein Phosphatase 2]General ChemistryProtein phosphatase 2Molecular biologynervous system diseasesProtein Biosynthesisbiology.proteinTrinucleotide repeat expansionTrinucleotide Repeat Expansion030217 neurology & neurosurgeryMid1 protein humanHeLa CellsTranscription FactorsNature communications
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The E3 Ubiquitin Ligase MID1 Catalyzes Ubiquitination and Cleavage of Fu

2014

Sonic Hedgehog (SHH)-GLI signalling plays an important role during embryogenesis and in tumorigenesis. The survival and growth of several types of cancer depend on autonomously activated SHH-GLI signalling. A protein complex containing the ubiquitin-ligase MID1 and protein phosphatase 2A (PP2A) regulates the nuclear localization and transcriptional activity of GLI3, a transcriptional effector molecule of SHH, in cancer cell lines with autonomously activated SHH signalling. However, the exact molecular mechanisms that mediate the interaction between MID1 and GLI3 remained unknown. Here, we show that MID1 catalyses the ubiquitination and proteasomal cleavage of the GLI3-regulator Fu. Our data…

metabolism [Microtubule Proteins]Ubiquitin-conjugating enzymeBiochemistrymetabolism [Protein Serine-Threonine Kinases]Ubiquitinmetabolism [Transcription Factors]Nuclear proteinSonic hedgehogbiologymetabolism [Protein-Serine-Threonine Kinases]Nuclear Proteinsrespiratory systemProtein-Serine-Threonine KinasesUbiquitin ligaseGene Expression Regulation NeoplasticGLI3 protein humanBiochemistryddc:540embryonic structuresMicrotubule Proteinsmetabolism [Hedgehog Proteins]Function and Dysfunction of the Nervous Systemmetabolism [Nuclear Proteins]Signal Transductionmetabolism [Kruppel-Like Transcription Factors]Proteasome Endopeptidase Complexanimal structuresSTK36 protein humanUbiquitin-Protein LigasesKruppel-Like Transcription FactorsNerve Tissue ProteinsProtein Serine-Threonine Kinaseschemistry [Ubiquitin-Protein Ligases]CatalysisZinc Finger Protein Gli3Cell Line TumorGLI3HumansHedgehog Proteinsmetabolism [Proteasome Endopeptidase Complex]metabolism [Cell Nucleus]Molecular Biologychemistry [Lysine]DNA PrimersCell Nucleusmetabolism [Nerve Tissue Proteins]UbiquitinLysineUbiquitinationCell BiologyProtein phosphatase 2chemistry [Ubiquitin]Proteasomebiology.proteinSHH protein humanhuman activitiesMid1 protein humanHeLa CellsTranscription FactorsJournal of Biological Chemistry
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Biomonitoring aktywny z zastosowaniem mchów w pobliżu Miasteczka Śląskiego

2017

Celem przeprowadzonych badań była ocena przyrostu stężeń wybranych analitów w próbkach mchów. Badania biomonitoringowe zanieczyszczenia aerozolu atmosferycznego prowadzono na terenie miejscowości Miasteczko Śląskie (województwo śląskie). Potencjalnym emitorem zanieczyszczeń na obszarze badań jest Huta Cynku „Miasteczko Śląskie”. Zastosowano metodę biomontoringu aktywnego (metoda woreczkowa), wykorzystując mchy z gatunku Pleurozium schreberi (rokietnik pospolity). Metale ciężkie w próbkach mchów oznaczono za pomocą absorpcyjnej spektrometrii atomowej (AAS). Wyniki badań zinterpretowano, wyznaczając współczynnik akumulacji względnej (RAF). Podczas prowadzenia eksperymentu uwzględniono odległo…

metale ciężkiebiomonitoring aktywnyMiasteczko Śląskiewspółczynnik akumulacji względnej RAFheavy metalsactive biomonitoringRelative Accumulation Factor (RAF)Miasteczko SlaskieProceedings of ECOpole
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Wpływ warunków prowadzenia eksperymentu na wyniki badań biomonitoringowych z zastosowaniem mchów

2017

metale ciężkiebiomonitoring aktywnyPleurozium schreberi mosseswspółczynnik akumulacji względnej RAFmchy Pleurozium schreberirelative accumulation factor RAFheavy metalsatomic absorption spectrometryactive biomonitoringabsorpcyjna spektrometria atomowaProceedings of ECOpole
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The Italian Society of Gastroenterology (SIGE) and the Italian Group for the study of Inflammatory Bowel Disease (IG-IBD) Clinical Practice Guideline…

2010

Biological therapies are an important step in the management of Inflammatory Bowel Diseases. In consideration of high cost and safety issues there is the need to have clear recommendations for their use. Despite the American Gastroenterological Association and the European Crohn's and Colitis Organisation have published exhaustive Inflammatory Bowel Disease guidelines, national guidelines may be necessary as cultural values, economical and legal issues may differ between countries. For these reasons the Italian Society of Gastroenterology and the Italian Group for the study of Inflammatory Bowel Disease have decided to elaborate the Italian guidelines on the use of biologics in Inflammatory…

methods Tumor Necrosis Factor-alphaAnti-Inflammatory AgentsUlcerativeDiseaseGUIDELINESHumanized Antibodieetiology Pregnancy Pregnancy ComplicationGastroenterologyInflammatory bowel diseaseetiology Opportunistic InfectionCrohn DiseasePregnancyNeoplasmsMonoclonaldrug therapy Remission Inductionantagonists /&/ inhibitorsSettore MED/12 - GastroenterologiaRemission InductionGastroenterologyAntibodies MonoclonalUlcerative colitisAnti-Inflammatory AgentItalyadverse effects/therapeutic use Intestinal FistulaTumor necrosis factor alphaFemaleImmunosuppressive Agentsmedicine.drugbiological drugsmedicine.medical_specialtyIBDOpportunistic InfectionsAntibodies Monoclonal HumanizedAutoimmune Diseasesadverse effects/therapeutic use Autoimmune DiseaseInternal medicinemedicineAdalimumabIntestinal FistulaHumansColitisdiagnosis/drug therapy/surgery Italy Neoplasmadverse effects/therapeutic use AntibodieHepatologydrug therapy Female Humans Immunosuppressive Agentbusiness.industryTumor Necrosis Factor-alphaAdalimumabCancermedicine.diseaseInfliximabInfliximabdigestive system diseasesdrug therapy Crohn Diseaseetiology ColitiPregnancy ComplicationsColitis Ulcerativebusiness
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Staphylococcus epidermidis virulences faktori un epidemioloģiskā nozīme

2016

Staphylococcus epidermidis svarīgākais virule nces faktors ir biofilmas veidošana. Lai diferencētu komensālos celmus no kolonizējošiem un invazīviem celmiem, pētījumā tika izmantotas fenotipiskās metodes, nosakot biofilmas veidošanu, antibiogrammu, un molekulārās bioloģijas metodes, nosakot virulences gēnus aap / ica A un mec A. Rezultāti liecina, ka biofilmu veidošana raksturīga klīniskajiem celmiem, statistiski ticami biežāk gēni aap/ica A bija noteikti klīniskajos S.epidermidis celmos, tie vis biežāk bija rezistenti pret meticilīnu (97,8%). S.epidermidis tipēšanai pirmo reizi tika pielietota MLST (multilokusu sekvenču tipēšana) metode. Pētījuma rezultāti ļauj secināt par S.epidermidis ge…

meticilīnrezistencemethicillin resistancegenotypingvirulence factorsMedicinegenotipēšanaS.epidermidisVeselības aprūpeMedicīnastaphylococci
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