Search results for "Actor"
showing 10 items of 19159 documents
Aging-associated changes in NF-kappa Β signaling
2000
NEURONS AND ASTROCYTES SHED EXTRACELLULAR VESICLES THAT SEEM TO VEHICLE ANGIOGENIC FACTORS
2007
Nicotinic receptor agonists as neuroprotective/neurotrophic drugs. Progress in molecular mechanisms
2007
In the present work we reviewed recent advances concerning neuroprotective/neurotrophic effects of acute or chronic nicotine exposure, and the signalling pathways mediating these effects, including mechanisms implicated in nicotine addiction and nAChR desensitization. Experimental and clinical data largely indicate long-lasting effects of nicotine and nicotinic agonists that imply a neuroprotective/neurotrophic role of nAChR activation, involving mainly alpha 7 and alpha 4 beta 2 nAChR subtypes, as evidenced using selective nAChR agonists. Compounds interacting with neuronal nAChRs have the potential to be neuroprotective and treatment with nAChR agonists elicits long-lasting neurotrophic e…
A new species of Rhopalosiphum (Hemiptera, Aphididae) on Chusquea tomentosa (Poaceae, Bambusoideae) from Costa Rica
2012
copyright 2012, Los autores y Zookeys. Datos incluidos por Lisela Moreira Carmona, responsable de depósitos del área de Patógenos y Plagas de Plantas (CIBCM-UCR). The new species Rhopalosiphum chusqueae Pérez Hidalgo & Villalobos Muller, is described from apterous viviparous females caught on Chusquea tomentosa in Cerro de la Muerte (Costa Rica). The identity of the species is supported both by the morphological features and by a molecular phylogenetic analysis based on a fragment of the mitochondrial DNA containing the 5’ region of the cytochrome c oxidase 1 (COI) and on the nuclear gene coding for the Elongation factor-1 alpha (EF1α). The taxonomic position of the new species is discussed…
Sakarība starp atkārtotu ķeizargriezienu un histerektomiju Rīgas dzemdību namā
2018
Mērķi. Sniegt labākos šobrīd pieejamos pierādījumus par mātes saslimstību, kas rezultējas ar histerektomiju un ir saistīta ar ĶG veikšanu sievietēm, kurām jau bijis ĶG. Salīdzināt riska faktorus grupās "histerektomija" un "ne histerektomija”. Noteikt bērna stāvokli, izmantojot Apgares skalu, pēc ĶG un pēc vaginālām dzemdībām. Materiāli un metodes. Pētījumā retrospektīvi analizēti dati par 1620 pacientēm, kas 2015 līdz 2017. gada novembrim. Visām sievietēm ir iepriekš bijis veikts ĶG, tātad: uz dzemdes bija rēta. No šīm pacientēm 1513 arī apskatītajās (sekojošās) dzemdībās tika veikts ĶG, bet 107 dzemdēja vagināli. Katrai pacientei tika reģistrēts vecums, grūtniecības nedēļa, iepriekšējo dze…
Influence of abiotic environmental factors on Pelargonium graveolens growth
2018
Ekstrakty pozyskiwane z roślin były używane, zwłaszcza w medycynie naturalnej, już od czasów antycznych. Przeprowadzono wiele badań, które dowodzą różnokierunkowych właściwości olejków eterycznych. Ten pozyskiwany z Pelargonium graveolens jest jedną z najbardziej cenionych substancji dla różnych gałęzi przemysłu, takich jak: kosmetyczna, mydlarska, perfumeryjna, aromaterapeutyczna, spożywcza czy medyczna. P. graveolens należy do rodziny Geraniaceae i zawiera około 280 gatunków różniących się morfologią i wyglądem zewnętrznym. Bylina ta jest krzewem sięgającym 1,3 m wysokości i ok. 1 m szerokości. Jest rodzima dla regionu Cape w południowej Afryce, natomiast została rozpowszechniona na więks…
Role of the NF-kB pathway and nitric oxide in mammary gland involution after weaning. Implications in breast cancer
2013
INTRODUCCIÓN La glándula mamaria es un órgano dinámico que alcanza su máximo desarrollo funcional con la lactancia, momento en el cual, a través de la producción de leche, aporta nutrientes y protección inmunológica a las crías de los mamíferos. Cuando la lactancia finaliza con el destete, el exceso de tejido glandular debe desaparecer y la glándula sufre una extensa remodelación hasta alcanzar nuevamente un estado pre-gestacional, preparada para un nuevo ciclo. La involución del tejido mamario es un proceso complejo durante el cual se suceden de forma coordinada una serie de eventos como la muerte de las células epiteliales secretoras, la proliferación de tejido adiposo circundante y la re…
The interactive effects of various nitrogen fertiliser formulations applied to urine patches on nitrous oxide emissions in grassland
2017
AbstractPasture-based livestock agriculture is a major source of greenhouse gas (GHG) nitrous oxide (N2O). Although a body of research is available on the effect of urine patch N or fertiliser N on N2O emissions, limited data is available on the effect of fertiliser N applied to patches of urinary N, which can cover up to a fifth of the yearly grazed area. This study investigated whether the sum of N2O emissions from urine and a range of N fertilisers, calcium ammonium nitrate (CAN) or urea ± urease inhibitor ± nitrification inhibitor, applied alone (disaggregated and re-aggregated) approximated the N2O emission of urine and fertiliser N applied together (aggregated). Application of fertili…
Decreasing muscle performance associated with increasing disease activity in patients with rheumatoid arthritis
2018
Objectives Increasing evidence suggests that inflammation has a detrimental effect on muscle strength. Our objective was to analyse the association between muscle performance and different disease activity levels in patients with rheumatoid arthritis (RA). Method A total of 199 consecutive outpatients were subject to cross-sectional assessment. Measurements of grip strength, endurance of the upper and lower limbs and trunk strength were combined as a muscle performance composite score (MPCS), using a standardised method. The disease activity for 28 joints (DAS28), radiographs of small joints (Larsen score), rheumatoid factor, body mass index (BMI), comorbidities and anti-rheumatic drugs wer…
Nobiletin and xanthohumol counteract the TNFα-mediated activation of endothelial cells through the inhibition of the NF-κB signaling pathway.
2022
Angiogenesis, a process characterized by the formation of new blood vessels from pre-existing ones, is a crucial step in tumor growth and dissemination. Given the ability of tumors to interfere with multiple or different molecular pathways to promote angiogenesis, there is an increasing need to therapeutically block tumor progression by targeting multiple antiangiogenic pathways. Natural polyphenols present health-protective properties, which are likely attributed to their ability to activate multiple pathways involved in inflammation, carcinogenesis, and angiogenesis. Recently, increased attention has been addressed to the ability of flavonoids, the most abundant polyphenols in the diet, t…