Search results for "Ada"
showing 10 items of 10244 documents
Update on intravitreal anti-tumor necrosis factor alpha therapies for ocular disorders
2014
Abstract Tumor necrosis factor alpha (TNF-?) is an important pro-inflammatory cytokine associated with a variety of ocular diseases. The currently available TNF-? inhibitors are etanercept, infliximab, adalimumab, golimumab, and certolizumab. Experimental and clinical studies on the intravitreal use of these agents have been reported with etanercept, infliximab, and adalimumab: etanercept has shown limited efficacy in scarce reports; infliximab has been associated with local safety concerns but appears to benefit certain cases; adalimumab has shown no efficacy in cases of age-related macular degeneration (AMD) or diabetic macular edema (DME), but the combination with bevacizumab may be effe…
The radial artery is larger than the ulnar.
2003
The radial artery is presently widely used as a bypass graft for coronary artery reconstruction. However, the traditional opinion that the ulnar artery is the larger forearm artery has been questioned.The internal diameters of the radial and ulnar arteries were measured at the wrist in postmortem angiograms of 24 cadavers. Differences in mean values of variables between ulnar and radial arteries were analyzed using the Wilcoxon test.The mean diameter of the radial artery was 28% larger than that of the ulnar artery in the right arm (p0.001) and 26% larger in the left arm (p0.001). In the right arm the radial artery was dominant in 20 of 24 cadavers (83%), the ulnar artery in 3 of 24 (13%), …
Kinematics of the ulna during pronation and supination in a cadaver study: implications for elbow arthroplasty
2003
Objective. Aim of this study was to exactly describe and quantify kinematics of the ulna during pro- and supination. Design. Biomechanical study in fresh frozen cadavers. Background. A previous MRI study revealed a varus/valgus motion of the ulna averaging 7.1° during pro-/supination. Axial rotation, however, could not be quantified. Methods. Sixteen arms were examined in a new apparatus that fixed the humerus on a template and allowed forearm rotation. Motion of a Kirschner wire placed in the ulna was recorded in steps of 30° by two perpendicularly arranged charge coupled device cameras during pro- and supination. Results. From supination to pronation the ulna showed a semi-lunar evasive m…
Uso de la tomografía computarizada en el diagnóstico de la anquilosis de la articulación temporomandibular: Presentación de dos casos clínicos
2006
La anquilosis de la articulación temporomandibular es definida como la abolición o limitación de los movimientos de dicha articulación. Radiográficamente la anquilosis demuestra aspectos bien característicos que facilitan el diagnóstico, sin embargo, su análisis en las técnicas radiográficas convencionales, en la mayoría de las veces, no se presenta de forma clara. Con la evolución de las técnicas radiográficas, la tomografía computarizada pasó a ser un examen de gran importancia en el diagnóstico de las anquilosis temporomandibulares. En vista de ello, el presente trabajo se propone mostrar y describir imágenes tomográficas de la anquilosis de esta articulación, presentando dos casos clíni…
Improving the cementation of the tibial component in knee arthroplasty : a study of four techniques in the cadaver.
2021
Aims The main objective of this study is to analyze the penetration of bone cement in four different full cementation techniques of the tibial tray. Methods In order to determine the best tibial tray cementation technique, we applied cement to 40 cryopreserved donor tibiae by four different techniques: 1) double-layer cementation of the tibial component and tibial bone with bone restrictor; 2) metallic cementation of the tibial component without bone restrictor; 3) bone cementation of the tibia with bone restrictor; and 4) superficial bone cementation of the tibia and metallic keel cementation of the tibial component without bone restrictor. We performed CT exams of all 40 subjects, and mea…
Pathogenesis of polymyalgia rheumatica
2018
Polymyalgia rheumatica (PMR) is a chronic, inflammatory disorder of unknown cause, almost exclusively occurring in people aged over 50 and often associated with giant cell arteritis. The evidence that PMR occurs almost exclusively in individuals aged over 50 may indicate that age-related immune alterations in genetically predisposed subjects contribute to development of the disease. Several infectious agents have been investigated as possible triggers of PMR even though the results are inconclusive. Activation of the innate and adaptive immune systems has been proved in PMR patients as demonstrated by the activation of dendritic cells and monocytes/macrophages and the altered balance betwee…
Acupuncture in the treatment of temporomandibular disorders, facial pain, and postural neuromuscular disorders. Presentation of a clinical case
2021
Abstract Background and objectives Temporomandibular disorders have a multifactorial etiology and involve the masticatory muscles, temporomandibular joint and associated structures. Therefore, different treatments are proposed and used. The aim of this paper is the use of acupuncture to treat temporomandibular disorders and associated symptoms. This article presents a clinical case study of a 39-year-old patient who presented temporomandibular disorders and headache of muscular origin. Results After 10 acupuncture sessions, the results were highly satisfactory, with complete relief of headache pain and absence of joint disorders. These results suggest the efficacy of acupuncture in the symp…
Morphomechanics of the humero-ulnar joint: I. Joint space width and contact areas as a function of load and flexion angle
1995
BACKGROUND Previous studies have shown that the trochlear notch is deeper than necessary for an exact fit with the humerus. However, humero-ulnar joint space width and contact areas have so far not been quantified for variations in the load and angle of flexion. METHODS Six fresh cadaveric specimens were investigated at 30 degrees, 60 degrees, 90 degrees, and 120 degrees of flexion and at loads of 25 and 500 N, simulating resisted elbow extension. The joint space width and contact were determined, using polyether casting material. RESULTS At 25 N all joints made contact in the ventral and dorsal aspects of the articular surfaces, whereas in the depth of the trochlear notch the joint space w…
OP0015 Induction of remission and maintenance in early, aggressive rheumatoid arthritis using adalimumab in combination with methotrexate with or wit…
2017
Background Remission is the current aim of early RA treatment. In patients with early, aggressive RA, combination with adalimumab (ADA) plus methotrexate (MTX) was superior to either MTX or ADA alone in obtaining clinical remission. Moreover, it has been demonstrated that a short-term aggressive treatment with high-dose glucocorticoids (GC) plus conventional DMARDs lead to long-term (up to 5 years) benefits. Objectives To compare the proportion of patients who achieve remission at 12 months, between two groups of subjects treated with ADA + MTX + high dose GC (intensive) and ADA + MTX + placebo (standard), and to evaluate the proportion of those maintaining remission at 24 months, after dis…
Waterjet dissection in pediatric cranioplasty
2010
Object Waterjet dissection has been shown to separate tissues of different resistance, with preservation of blood vessels. In cranioplasty, separation of subcutaneous tissue and dura mater is often difficult to achieve because the various tissue layers strongly adhere to each other after decompressive craniotomy. In the present study, the potential advantages and drawbacks of the waterjet technique in cranioplasty after craniectomy and duraplasty are addressed. Methods The waterjet effect on fresh human cadaveric dura mater specimens as well as on several dural repair patches was tested in vitro under standardized conditions, with waterjet pressures up to 80 bar. Subsequently, 8 pediatric …