Search results for "Adaptive"
showing 10 items of 792 documents
Visual simulation through different intraocular lenses using adaptive optics: Effect of tilt and decentration
2011
Purpose To analyze visual quality differences between intraocular lenses (IOLs) and assess the impact of IOL decentration and tilt on visual quality. Setting University of Valencia, Valencia, Spain. Design Cohort study. Methods The crx1 adaptive optics visual simulator was used to simulate the wavefront aberration pattern of 2 commercially available aspheric aberration-correcting IOLs (Acrysof IQ SN60WF and Tecnis ZA9003) and 2 spherical IOLs (Akreos Adapt and Triplato) in 5 situations: centered, decentered 0.2 mm and 0.4 mm, and tilted 2 degrees and 4 degrees. Monocular distance visual acuity at 100%, 50%, and 10% contrast and the depth of focus were measured. Results Ten eyes of 10 patien…
Simulated prototype of posterior chamber phakic intraocular lens for presbyopia correction.
2014
Purpose To evaluate the visual impact of adding different spherical aberration values to an Implantable Collamer Lens phakic intraocular lens (pIOL) to increase the depth of focus using an adaptive optics visual simulator. Setting University of Valencia, Valencia, Spain. Design Experimental study. Methods Wavefront aberrations in −3.00 D and −6.00 diopter (D) pIOLs were measured in vitro. Afterward, different simulated pIOL experimental prototypes were created along with variances in the spherical aberration. An adaptive optics visual simulator was used to simulate vision after the implantation of the different pIOL prototypes from their wavefront aberrations. The corrected distance visual …
Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells
2016
Aberrant immune responses represent the underlying cause of central nervous system (CNS) autoimmunity, including multiple sclerosis (MS). Recent evidence implicated the crosstalk between coagulation and immunity in CNS autoimmunity. Here we identify coagulation factor XII (FXII), the initiator of the intrinsic coagulation cascade and the kallikrein–kinin system, as a specific immune cell modulator. High levels of FXII activity are present in the plasma of MS patients during relapse. Deficiency or pharmacologic blockade of FXII renders mice less susceptible to experimental autoimmune encephalomyelitis (a model of MS) and is accompanied by reduced numbers of interleukin-17A-producing T cells.…
Observational Prospective Natural History of Patients with Sanfilippo Syndrome Type B
2017
To evaluate the natural course of disease progression in patients with Sanfilippo syndrome type B (mucopolysaccharidosis type IIIB), identify potential end points for future therapy trials, and characterize biomarkers related to the disease.A prospective, multicenter study was conducted. Baseline, 6-month, and 12-month assessments included neurodevelopmental status (Bayley Scales of Infant Development, Third edition), adaptive status (Vineland Adaptive Behavior Scales, Second Edition), volumetric brain magnetic resonance imaging, cerebrospinal fluid heparan sulfate, and urine glycosaminoglycan (GAG) measurements.Nineteen patients aged 1.6-31.7 years were enrolled. Over 12 months, cognition,…
Resilience and Coping as Predictors of Well-Being in Adults.
2016
Well-being is one of the keys to successful and optimal development across the lifespan. Based on the idea that development involves changes in individuals' adaptive capacity to meet their needs over time, the changes that occur in the second half of life require effort to adapt to the new reality. This study used a structural model to test the effects of coping strategies and resilience on well-being in a sample of 305 mid-life adults. Several constructs were measured: coping strategies, resilience, and well-being. A final model was obtained with good fit indices; psychological well-being was positively predicted by resilience and negatively by emotional coping. Moreover, positive reapprai…
Are student nurses ready for new technologies in mental health? Mixed-methods study
2020
Abstract Background Technical innovations such as ecological momentary assessment (EMA), machine learning (ML), computerized adaptive testing (CAT), Digital Phenotyping, Clinical Decision Support Systems (CDSS), Algorithms, and Biomarkers have caused a paradigm shift in psychiatric care. The aim of the present study was to explore how student nurses view this paradigm shift, by assessing the acceptability of smartphone-based EMA, CAT, and biosensor-based Digital Phenotyping. We also investigated the factors affecting this acceptability. Method Student nurses recruited via nursing schools participated in a quantitative study involving the screenplay method, in which they were exposed to two …
Reliability, Validity, and Factor Structure of the Maladaptive Daydreaming Scale (MDS–16) in an Italian Sample
2019
Maladaptive daydreaming (MD) is an extensive fantasy activity that replaces human interaction and interferes with work and interpersonal functioning. In this study, we investigated the nomological network of the MD construct and examined the psychometric properties of the Maladaptive Daydreaming Scale (MDS-16) in an Italian sample. The MDS-16 is a self-report measure composed of 16 items designed to assess MD. Participants in this study were 468 individuals (333 volunteers, 56.8% female; 135 self-diagnosed maladaptive daydreamers, 78.5% female) between 18 and 56 years of age. MDS-16 scores showed good internal reliability. An exploratory factor analysis suggested a 2-factor solution (interf…
Prediction of the hemoglobin level in hemodialysis patients using machine learning techniques
2013
HighlightsDifferent prediction algorithms were used to predict Hb levels in CRF patients.Prediction errors in the validation cohorts of patients were around 0.6g/dl.Difficulty to obtain lower errors due to the measuring machine precision (0.2g/dl).Relevance analysis of features have been applied for each predictor. Patients who suffer from chronic renal failure (CRF) tend to suffer from an associated anemia as well. Therefore, it is essential to know the hemoglobin (Hb) levels in these patients. The aim of this paper is to predict the hemoglobin (Hb) value using a database of European hemodialysis patients provided by Fresenius Medical Care (FMC) for improving the treatment of this kind of …
The effects of instrumental reminiscence on resilience and coping in elderly
2014
A B S T R A C T Objectives: Aging, as a stage of development is marked by major changes to which the subject must adapt. Instrumental reminiscence is based on recalling times one coped with stressful circumstances, and analyzing what it took to adapt in those situations. The purpose of the present study was to analyze the effectiveness of an instrumental reminiscent program to enhance adaptive capacity (problemfocused coping and emotion-focused) and resilience in older adults. Method: Thirty participants noninstitutionalized conducted a pre and post assessment on a treatment consisting of the Mini-Mental State Examination (MMSE), Brief Resilient Coping Scale and Stress Coping Questionnaire …
Transient seizure onset network for localization of epileptogenic zone: effective connectivity and graph theory-based analyses of ECoG data in tempor…
2018
Objective: Abnormal and dynamic epileptogenic networks cause difficulties for clinical epileptologists in the localization of the seizure onset zone (SOZ) and the epileptogenic zone (EZ) in preoperative assessments of patients with refractory epilepsy. The aim of this study is to investigate the characteristics of time-varying effective connectivity networks in various non-seizure and seizure periods, and to propose a quantitative approach for accurate localization of SOZ and EZ. Methods: We used electrocorticogram recordings in the temporal lobe and hippocampus from seven patients with temporal lobe epilepsy to characterize the effective connectivity dynamics at a high temporal resolution …