Search results for "Addiction"

Italy

2009

Conditioned place preference paradigm can be a mouse model of relapse to opiates

2001

With the object of determining the usefulness of the conditioned place preference (CPP) paradigm as a model of relapse to opiates, the effects of the re-exposure to morphine are explored in male mice which had undergone a process of extinction of conditioning. Morphine (40 mg/kg) produces a CPP which lasts up to 15 days after conditioning. When it has completely extinguished (45 days), a non contingent re-exposure to the drug again produces the same preference. These results suggest that the CPP paradigm may be used in mice to study the mechanisms of relapse to opiates in addicts.

Thresholds of hope: stories of lacking generosity

2019

ABSTRACTHope is a pivotal part of recovery in a broad range of health conditions, including those relating to the field of mental health and substance abuse. People who experience co-occurring ment...

The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers

2021

Genetic analysis of the association between alcohol, cocaine, and opiate addiction and variable number tandem repeat (VNTR) polymorphisms in monoamine oxidase B (MAOB) and serotonergic 5-hydroxytryptamine (serotonin) receptor 1B and 2C (HTR1B 21 and HTR2C) pathway genes was performed in a sample of 302 polyconsumers. Our genetic association analysis revealed a significant association between a 184 base pair (bp) VNTR polymorphism in the MAOB gene and addiction to cocaine and opiates. This work highlights new genetic marker associations in cocaine and opiate polyconsumer addictions. These data help to clarify and quantify the complex role of genetics in addictive disorders, as well as their …

Gestational exposure to cocaine alters cocaine reward

2006

Exposure of the developing foetus to drugs of abuse during pregnancy may lead to persistent abnormalities of brain systems involved in drug addiction. Mice prenatally exposed to cocaine (25 mg/kg), physiological saline or non-treated during the last 7 days of pregnancy were evaluated in adulthood for the rewarding properties of cocaine (3, 25 and 50 mg/kg), using the conditioned place preference procedure. Dams treated with physiological saline gained significantly less weight over the course of gestation than controls; no other differences were observed in the maternal and offspring data. All the animals developed preference to 3 and 25 mg/kg of cocaine, but those treated prenatally with c…

Telefonische Beratung für Glücksspielsüchtige – der heiße Draht ins Hilfesystem? Akzeptanz und Nutzung der Mainzer Hotline Verhaltenssucht

2018

Zusammenfassung Ziel Trotz erheblicher psychosozialer Folgen findet nur ein geringer Anteil der pathologischen Glücksspieler den Weg in die Beratung und Behandlung. Telefonische Beratungsangebote (Hotlines) sollen Betroffenen den Weg in das Suchthilfesystem erleichtern. In Deutschland fehlt es an Forschung zur Inanspruchnahme und den Effekten von Hotlines. Es soll die Frage beantwortet werden, ob telefonische Beratungsangebote dazu beitragen, Glücksspielsüchtigen den Weg in das Suchthilfesystem zu bahnen. Methodik Alle Erstanrufe, die auf der Hotline Verhaltenssucht der Universitätsmedizin Mainz zwischen 2013 und 2016 aufgrund eines problematischen Glücksspielverhaltens eingingen, wurden mi…

Komorbide Internetsucht unter Patienten der stationären Suchtrehabilitation: Eine explorative Erhebung zur klinischen Prävalenz

2012

Anliegen: Die exzessive Nutzung des Internets wird als substanzungebundene Form einer Abhangigkeitserkrankung diskutiert. Laut Pravalenzschatzungen ist 1 % der deutschen Bevolkerung betroffen. Ungeklart ist, inwieweit Internetsucht komorbid unter Patienten der stationaren Suchtrehabilitation auftritt. Methode: In 15 Kliniken wurden alle innerhalb eines halben Jahres aufgenommenen Patienten auf das Vorliegen von Internetsucht gescreent. Ergebnisse: 4,2 % der Patienten erfullten die Kriterien. Diese waren haufiger mannlich mit den Primardiagnosen Cannabisabhangigkeit und pathologisches Glucksspiel. Schlussfolgerungen: Dies verdeutlicht den Bedarf an entsprechenden Routinescreenings innerhalb …

Cross‐national validation of the Social Media Disorder‐scale : Findings from adolescents from 44 countries

2022

Background and aims There is currently no cross-national validation of a scale that measures problematic social media use (SMU). The present study investigated and compared the psychometric properties of the Social Media Disorder (SMD)-scale among young adolescents from different countries. Design Validation study. Setting and participants Data came from 222,532 adolescents from 44 countries participating in the Health Behaviour in School-aged Children (HBSC) survey (2017/2018). The HBSC survey was conducted in the European region and Canada. Participants were on average 13.5 years old (SD = 1.6) and 51.2% were girls. Measurement Problematic SMU was measured using the 9-item SMD-scale with …

Dipendenza da sostanze ed esperienze sfavorevoli infantili: uno studio empirico condotto con la Childhood Experiences of Care and Abuse Interview (CE…

2015

Backgroud: Numerose ricerche rilevano l’impatto che esperienze sfavorevoli infantili possono avere sulla dipendenza da sostanze. Metodo: 32 tossicodipendenti maschi in trattamento presso comunità e 32 soggetti appartenenti a un gruppo non clinico sono stai intervistati attraverso la Childhood Experience of Care and Abuse. Risultati: La maggior parte dei soggetti del gruppo clinico ha esperito maggiori esperienze (p<0,05) di negligenza, abuso fisico, abuso psicologico e ha ricevuto forme più inadeguate di supervisione e disciplina. Inoltre, i soggetti del gruppo clinico sono stati esposti a un numero più elevato (p=0,01) di esperienze sfavorevoli. Conclusioni: I risultati suggeriscono la pre…

2021

(1) Background: The use of social media has become an integral part of adolescents’ daily lives. However, the intensive use of social media can develop into a health-threatening addiction, but unfavourable health consequences can occur even with less use. Social media user groups categorized as no-risk, moderate risk (of developing problematic behaviour), and problematic use were examined with reference to their prevalence, their associations with individual determinants and health, and the increased health risk between groups. (2) Methods: The Finnish nationally representative HBSC data (persons aged 11, 13, and 15, n = 3408) and descriptive and binary logistic regression analysis were app…