Search results for "Adjunct"
showing 10 items of 33 documents
Homotopy limits for 2-categories
2008
AbstractWe study homotopy limits for 2-categories using the theory of Quillen model categories. In order to do so, we establish the existence of projective and injective model structures on diagram 2-categories. Using these results, we describe the homotopical behaviour not only of conical limits but also of weighted limits. Finally, pseudo-limits are related to homotopy limits.
Triple planes with $p_g=q=0$
2019
We show that general triple planes with p_g=q=0 belong to at most 12 families, that we call surfaces of type I,..., XII, and we prove that the corresponding Tschirnhausen bundle is direct sum of two line bundles in cases I, II, III, whereas is a rank 2 Steiner bundle in the remaining cases. We also provide existence results and explicit constructions for surfaces of type I,..., VII, recovering all classical examples and discovering several new ones. In particular, triple planes of type VII provide counterexamples to a wrong claim made in 1942 by Bronowski.
Double adjunctions and free monads
2011
We characterize double adjunctions in terms of presheaves and universal squares, and then apply these characterizations to free monads and Eilenberg--Moore objects in double categories. We improve upon our earlier result in "Monads in Double Categories", JPAA 215:6, pages 1174-1197, 2011, to conclude: if a double category with cofolding admits the construction of free monads in its horizontal 2-category, then it also admits the construction of free monads as a double category. We also prove that a double category admits Eilenberg--Moore objects if and only if a certain parameterized presheaf is representable. Along the way, we develop parameterized presheaves on double categories and prove …
Colour Doppler-guided haemorrhoidal artery ligation: an adjunct in identification of haemorrhoidal vessels.
2012
Not available (case report)
Addition of a fixed combination of brinzolamide 1%/timolol 0.5% to prostaglandin monotherapy in patients with glaucoma or ocular hypertension
2011
Katrin Lorenz1, Klaus Rosbach2, Andreas Matt3, Norbert Pfeiffer11University Medical Center, Johannes Gutenberg-Universität Mainz, Mainz, Germany; 2Private practice, Mainz, Germany; 3Private practice, Köln-Hohenhaus, GermanyBackground: This study was conducted to evaluate the safety and efficacy of adding a fixed combination of brinzolamide 1%/timolol 0.5% to prostaglandin analog (PGA) monotherapy in patients with primary open-angle glaucoma, pigment dispersion glaucoma, or ocular hypertension who require additional intraocular pressure (IOP) reduction.Methods: This was a prospective, multicenter (n = 5), open-label, single-arm, Phase IV clinical trial in which patients cur…
Long Distance Case Assignment in Finnish*
2012
. Long distance case assignment remains a little studied corner of grammar. This paper documents such phenomenon in Finnish. In this language the choice of the direct object case depends on several local and remote case assigners. Remote case assigners need not occupy the same clause as the assignees: case assignment penetrates any number of non-finite clause boundaries of all types, adjunct boundaries, and even noun heads. Two hypotheses concerning the phenomenon are put forward: one, which says that the phenomenon is essentially an illusion and involves only local case assignment, and another, which says that genuine long distance case assignment is at issue. The latter hypothesis will f…
Pied-piping domains and adjunction coincide in Finnish
2012
It is well-known thatwh-pronouns may pied-pipe their containing host phrases as they move to their final scope positions. In Finnish, such pied-piping requires further that awh-element is situated at the left edge of host phrases, a position in which it ends up either through base generation or throughwh-movement. This article investigates which independent properties define such pied-piping domains. An empirical generalization will be defended according to which a phrase constitutes such pied-piping domain if and only if it is adjoinable. The hypothesis that pied-piping domains are islands is put into question. Secondarywh-movement, pied-piping and adjunction are thus intrinsically linked …
Ideal-valued topological structures
2010
With L a complete lattice and M a continuous lattice, this paper demonstrates an adjunction between M -valued L-topological spaces (i.e. (L,M )-topological spaces) and Idl(M )-valued L-topological spaces where Idl(M ) is the complete lattice of all ideals of M . It is shown that the right adjoint functor provides a procedure of generating (L,M )-topologies from antitone families of (L,M )-topologies. This procedure is then applied to give an internal characterization of joins in the complete lattice of all (L,M )-topologies on a given set.
The lipid-lowering effects of lomitapide are unaffected by adjunctive apheresis in patients with homozygous familial hypercholesterolaemia – A post-h…
2015
AbstractObjectiveLomitapide (a microsomal triglyceride transfer protein inhibitor) is an adjunctive treatment for homozygous familial hypercholesterolaemia (HoFH), a rare genetic condition characterised by elevated low-density lipoprotein-cholesterol (LDL-C), and premature, severe, accelerated atherosclerosis. Standard of care for HoFH includes lipid-lowering drugs and lipoprotein apheresis. We conducted a post-hoc analysis using data from a Phase 3 study to assess whether concomitant apheresis affected the lipid-lowering efficacy of lomitapide.MethodsExisting lipid-lowering therapy, including apheresis, was to remain stable from Week −6 to Week 26. Lomitapide dose was escalated on the basi…
Brinzolamide/brimonidine fixed-dose combination bid as an adjunct to a prostaglandin analog for open-angle glaucoma/ocular hypertension.
2019
Purpose: To evaluate the additive intraocular pressure–lowering effect of twice-daily brinzolamide 1%/brimonidine 0.2% fixed-dose combination (BBFC) as an adjunct to a prostaglandin analog (PGA) in patients with open-angle glaucoma or ocular hypertension insufficiently controlled with PGA monotherapy. Methods: In this Phase 4, double-masked trial, patients aged ⩾18 years, with a mean intraocular pressure of ⩾19 and <32 mm Hg in at least one eye were randomized (1:1) to receive BBFC + PGA ( n = 96) or vehicle + PGA ( n = 92) for 6 weeks. The primary endpoint was the mean change in diurnal intraocular pressure from baseline (averaged over 09:00 and 11:00 h) at Week 6. Results: The mean diu…