Search results for "Adma"
showing 10 items of 15 documents
Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: Possible therapeutic targets?
2013
International audience; Nitric oxide (• NO) is synthetized enzymatically from L-arginine (L-Arg) by three NO synthase isoforms, iNOS, eNOS and nNOS. The synthesis of NO is selectively inhibited by guanidino-substituted analogs of L-Arg or methylarginines such as asymmetric dimethylarginine (ADMA), which results from protein degradation in cells. Many disease states, including cardiovascular diseases and diabetes, are associated with increased plasma levels of ADMA. The N-terminal catalytic domain of these NOS isoforms binds the heme prosthetic group as well as the redox cofactor, tetrahydrobiopterin (BH 4) associated with a regulatory protein, calmodulin (CaM). The enzymatic activity of NOS…
Water reuse from wastewater treatment: The transition towards circular economy in the water sector
2022
Water is crucial for economic development since it interacts with the agricultural, production, and energy sec-tors. However, the increasing demand and climate change put pressure on water sources. This paper argued the necessity of using reclaimed water for irrigation within the scope of a circular economy. The barriers (i.e., technological and economic, institutional/regulatory, and social) to water reuse practices were revealed. Lessons on how to overcome the barriers were learned from good practices. The roadmaps adopted in the European Union for the transition towards the circular economy were reviewed. It has been observed that these roadmaps are generally on the circularity of solid …
Atrial fibrillation is associated with a marker of endothelial function and oxidative stress in patients with acute myocardial infarction
2016
IF 4.066; International audience
Iron metabolism markers and l-arginine derivatives in coronary artery disease : highlighting, assessment and role of oxidative stress in acute myocar…
2015
Myocardial infarction (MI) is mostly caused by complications of atherosclerosis, whose the development would be initiated by a dysfunction of the vascular endothelium, characterized by an inflammatory condition and oxidative stress.In this pathogenesis, iron interacts at different levels and also has a major role in the development of endothelial dysfunction. Hepcidin and erythroferrone (discovered earlier as the myonectin/CTRP 15) participate in a major way in regulating certain stages of iron metabolism.Asymmetric dimethylarginine (ADMA), a marker of endothelial dysfunction is associated with most cardiovascular risk factors. Symmetrical dimethyl-arginine (SDMA), its stereoisomer, has an …
Sprint and endurance training in relation to redox and inflammatory status and biomarkers of aging in master athletes
2020
Purpose Studies have shown a positive influence of intense athletic training on several biomarkers of aging, but it remains unclear whether this influence is dependent of exercise-training-mode. This study compared redox balance, cytokine levels and biomarkers of aging between master sprinters and endurance athletes, as well as in young and middle-aged individuals as controls. Methods Participants were male master sprinters (SA, 50±8.9yrs; n=13) and endurance runners (EA, 53±8.2yrs; n=18) with remarkable athletic experience (∼25yrs of practice), besides untrained young (YC, 22.7±3.9yrs; n=17) and age-matched controls (MC, 45.5±9.8yrs; n=12). Anamnesis, anthropometrics, biomarkers of aging, …
Ripensare la corresponsabilità educativa tra scuola e famiglia: vissuti e riflessioni di dirigenti scolastici al tempo del Covid-19
2021
Il Patto di corresponsabilità educativa sancisce formalmente l’alleanza educativa tra scuola e famiglia. Tuttavia, oggi il rischio è che il Patto rimanga solo un atto formale. Appare, allora, necessario approfondire il senso e le modalità pratiche della partnership scuola-famiglie. Nel fare ciò, il ruolo del Dirigente Scolastico risulta fondamentale per la promozione di una vera e propria partnership educativa. Il paper presenta un approfondimento teorico sul tema citato, con riferimento all’attuale crisi pandemica e alcuni risultati preliminari di un’indagine esplorativa svolta durante l’A.S. 2020/2021 con venti dirigenti scolastici di scuole siciliane per comprendere come la relazione è c…
The societal contexts for sound and music computing: Research, education, industry, and socio-culture
2007
Abstract The paper addresses the various contexts that determine the societal framework for research in the field of sound and music computing. Four of these contexts are identified, namely, the research context, the educational context, the industrial context and the socio-cultural context. For each context, the major trends are analysed and summarized as short statements, thus providing a background in which the state-of-the-art and the challenges of sound and music research can be situated.
Carotid restenosis is associated with plasma ADMA concentrations in carotid endarterectomy patients
2011
Abstract Background: The aim of this work has been to study the association between plasma asymmetric dimethylarginine (ADMA) concentrations and carotid stenosis in a group of 64 patients undergoing carotid endarterectomy (CEA). Methods: Arginine, ADMA and symmetric dimethylarginine (SDMA) were measured using capillary electrophoresis with UV detection. An evaluation of plasma concentrations of total cysteine (tCys) and total homocysteine (tHcy) was also performed. Results: Pearson’s analysis show a positive correlation between ADMA and carotid stenosis (r=0.37, p=0.003), which is also confirmed after stepwise multiple linear regression analysis. ADMA plasma concentrations were significantl…
Dienvidkorejas alternatīvās mūzikas attīstība un ietekmējošie faktori
2022
Bakalaura darba nosaukums ir ‘’Dienvidkorejas alternatīvās mūzikas attīstība un ietekmējošie faktori’’. Darbā tiek apskatīta mūsdienās mazāk pazīstamā Dienvidkorejas alternatīvās un indī mūzikas daļa par kuras apstākļiem mūsdienās nav daudz pētījumu. Darbs veikts ar nolūku, lai kaut mazliet palīdzētu Korejas neatkarīgajiem mūziķiem gūt plašāku uzmanību un neļautu pilnībā izzust šai Korejas mūzikas daļai. Ar ieskatu tās vēsturē un intervijas palīdzību bija iespējams secināt to, kāds ir šīs mūzikas attīstības virziens. Darbs sastāv no 3 nodaļām no kurām pirmajā un trešajā ir 3-4 apakšnodaļas. Ir arī pielikums kurā iekļauta intervija oriģinālajā valodā (angļu valodā) un uzskatei noderīgs attēl…
Decreased plasma soluble RAGE in patients with hypercholesterolemia: Effects of statins
2007
The receptor for advanced glycation endproducts (RAGE) is overexpressed at sites of vascular pathology. A soluble RAGE isoform (sRAGE) neutralizes the ligand-mediated damage by acting as a decoy. We hypothesized that in hypercholesterolemia up-regulation of the ligand-RAGE axis may bridge impairment of nitric oxide biosynthesis with oxidative stress. We measured in 60 hypercholesterolemic patients and 20 controls plasma total sRAGE levels, urinary 8-iso-prostaglandin (PG) F(2alpha) excretion, and plasma levels of asymmetric dimethylarginine (ADMA). The effects of two structurally different statins (pravastatin and atorvastatin) on these parameters were analyzed in 20 hypercholesterolemic su…