Search results for "Administration"

Effect of chemical enhancers on the in vitro percutaneous absorption of sumatriptan succinate

2005

The effects of percutaneous enhancers on the transdermal absorption of sumatriptan succinate were investigated by in vitro permeation studies. Pretreatment of porcine skin with ethanol (vehicle), polyethylene glycol 600, Span 20, oleic acid, R-(+)-limonene, alpha-bisabolol and 1,8-cineole (at 5% in ethanol, w/w) produced in all cases an increase in the flux of sumatriptan. The amount of sumatriptan retained in the skin was also determined. Ethanol has showed a low but significant increment on the drug transdermal flux. Treatment of the skin with alpha-bisabolol shows the same enhancer effect than ethanol. Span 20, oleic acid, and polyethylene glycol 600 have shown a moderate enhancing activ…

Transcutol containing vesicles for topical delivery of minoxidil

2010

The aim of this work was to evaluate the ability of Transcutol (Trc) to produce elastic vesicles with soy lecithin (SL) and study the influence of the obtained vesicles on in vitro (trans)dermal delivery of minoxidil. To this purpose, so-called penetration enhancer-containing vesicles (PEVs) were prepared using Trc aqueous solutions (5-10-20-30% v/v) as hydrophilic phase. SL liposomes, without Trc, were used as control. Prepared formulations were characterized in terms of size distribution, morphology, zeta potential, deformability, and rheological behavior. The influence of the obtained PEVs on (trans)dermal delivery of minoxidil was studied by in vitro diffusion experiments through pig sk…

Consumers’ criteria to select food retailers revisited in the current environment.

2022

Food retailing is undergoing major transformations, particularly in France. Hypermarkets are declining, hard-discount stores are gentrifying, e-commerce is mixing with physical distribution, convenience stores are gaining presence and market shares, other forms are emerging: short, collaborative or cooperative channels. Consumers are clearly changing their buying patterns. How do people currently select a form of sale? Are there any changes in their selection criteria or in their perception of food retailing that can explain that they are turning away from hypermarkets to go to more meaningful places? The objective of this research is to revisit the consumers’ criteria to select a form of s…

Digital competence across boundaries - beyond a common Nordic model of the digitalisation of K-12 schools?

2021

This paper explores policy related to digital competence and the digitalisation of Nordic K-12 schools. Anchored in some key transnational policies on digital competence, it describes some current Nordic movements in the national policies of Denmark, Finland, Norway and Sweden. The concept of boundary objects is used as an analytical lens, for understanding digital competence as a plastic and temporal concept that can be used to discuss the multi-dimensional translation of this concept in these Nordic countries. The paper ends with a discussion of the potential to view digital competence as a unifying boundary object that, with its plasticity, temporality and n-dimensionality, can show sign…

L'influence des facteurs institutionnels sur la politique d'information financière des entreprises. Une analyse à la lumière du cas français

2009

International audience; L'influence des facteurs institutionnels sur la politique d'information financière des entreprises. Une analyse à la lumière du cas français.

The burnout syndrome and associated personality disturbances. The study in three graduate programs in Dentistry at the University of Barcelona

2008

Objective: Determine the presence of ?burnout? syndrome and characteristic personality patterns in the students and faculty of three graduate programs in Dentistry at the University of Barcelona: Department of Oral Surgery and Implantology, Department of Orthodontics and Department of Integrated Dentistry. Materials and Methods: The study was carried out in 78 dentists. The level of ?burnout? was evaluated using the Maslach Burnout Inventory, socio-demographic variables and, finally, the personality test. Results: Oral surgeons constituted the group of highlevel ?burnout?. The profile of an individual with a propensity to ?burn out? is a single man, with a median age of 27, that is in the f…

The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome

2020

© 2020 by the authors.

Les déterminants à l’adoption de pratiques de RSE par les TPE et les PME – Une étude en région BFC

2023

Safety and side effects of human and ovine corticotropin-releasing hormone administration in man.

1991

Synthetic human and ovine corticotropin-releasing hormone (hCRH, oCRH) are commonly used as a diagnostic tool of the hypothalamo-pituitary-adrenal axis. In this paper reports about side effects after various modes of CRH-application are analyzed and compared to our corresponding data of human studies with hCRH and oCRH. Generally, CRH is well tolerated after single administration and interval-application of standard doses, although minor side effects appear sometimes after higher doses (greater than 200 micrograms hCRH, oCRH) of CRH-bolus-injections. Predominantly the cardiovascular system (e.g. tachycardia, hypotension, flushing) is affected; neuropsychological symptoms are only seen spora…

Research and development expenditure in France : an analysis by sector

1996

La taille des entreprises a toujours été considérée comme une variable déterminante dans l'explication de leurs stratégies (stratégie de concentration ou stratégie d'innovation). Ce travail se propose d'analyser la relation évoquée par J. Schumpeter entre la taille des entreprises et le montant des dépenses en recherche-développement. Tout en suivant la méthodologie utilisée en Economie Industrielle, nous avons d'abord conduit une analyse exploratoire sur cette relation. Cette étude, réalisée au niveau branche, montre que la taille (mesurée par le nombre de salariés, la production effective ou la valeur ajoutée) exerce une influence positive sur les dépenses en recherche-développement (mesu…