Search results for "Adrenal axis"
showing 7 items of 17 documents
The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance
2005
During the last few years, the endocannabinoid system has emerged as a highly relevant topic in the scientific community. Many different regulatory actions have been attributed to endocannabinoids, and their involvement in several pathophysiological conditions is under intense scrutiny. Cannabinoid receptors, named CB1 receptor and CB2 receptor, first discovered as the molecular targets of the psychotropic component of the plant Cannabis sativa, participate in the physiological modulation of many central and peripheral functions. CB2 receptor is mainly expressed in immune cells, whereas CB1 receptor is the most abundant G protein-coupled receptor expressed in the brain. CB1 receptor is expr…
The influence of personality on the effect of iTBS after being stressed on cortisol secretion
2019
Over the last years, individualization of repetitive Transcranial Magnetic Stimulation (rTMS) parameters has been a focus of attention in the field of non-invasive stimulation. It has been proposed that in stress-related disorders personality characteristics may influence the clinical outcome of rTMS. However, the underlying physiological mechanisms as to how personality may affect the rTMS response to stress remains to be clarified. In this sham-controlled crossover study, after being stressed by the Trier Social Stress Test, 38 healthy females received two sessions of intermittent theta burst stimulation (iTBS) applied to the left dorsolateral prefrontal cortex. To take possible personali…
Cortisol awakening response and cognitive performance in hypertensive and normotensive older people.
2016
Healthy older people with a cortisol awakening response (CAR) of decreased magnitude show worse frontal cortex-related cognitive performance. Systemic hypertension has been related to a CAR of decreased magnitude. Additionally, worse executive function and processing speed have been observed in older people with systemic hypertension. This is the first study to examine the relationship between the CAR (measured with six saliva samples at home on two consecutive weekdays) and cognitive performance, in both hypertensive (n=26) and normotensive (n=28) older people (from 56 to 78years old). Hypertensive participants showed lower morning cortisol secretion, and they also woke up earlier. No diff…
Organizational and activational effects of testosterone in two populations with high androgenization susceptibility = Efectos organizadores y activad…
2013
Los esteroides sexuales como la testosterona (T) producen una organización y/o modificaciones relativamente permanentes de la estructura y función del sistema nervioso central. Una alta exposición prenatal a la T podría estar relacionada con una mayor sensibilidad a los efectos activadores de dicha hormona durante la edad adulta. Por otra parte, las fluctuaciones en los niveles endógenos de T pueden modificar transitoriamente las capacidades socio-cognitivas. Así, la conducta y los procesos cognitivos podrían ser el resultado de la interacción entre los efectos hormonales organizadores y activadores. La T podría ser considerada como un predictor de rasgos masculinizados tales como los rasgo…
Loneliness Mediates the Relationship Between Early Life Stress and Perceived Stress but not Hypothalamic–Pituitary–Adrenal Axis Functioning
2021
Many authors have proposed that early life stress (ELS) provokes a dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis and contributes negatively to the management of stress in adulthood. However, these associations have not always been observed, making it necessary to include new factors that could explain the different results found. In this regard, people with ELS experiences report less social support during adulthood, suggesting that loneliness could be a mediating factor. Thus, our aims were to investigate whether ELS was related to both perceived stress and diurnal HPA axis activity, and whether loneliness mediates these relationships, in a community sample (N=187, 18–55ye…
Hypothalamic-Pituitary-Adrenal axis and cognitive function in healthy older people: genetic, situational and individual factors
2019
The world population is getting older, and this age group faces important health challenges, among which age-related cognitive decline stands out. Therefore, it is important to identify vulnerability and protective health factors in order to understand ways to prevent cognitive decline. This thesis aimed to address the relationship between the Hypothalamic–Pituitary–Adrenal (HPA) axis and cognitive functioning during aging, taking into account genetic (Apolipoprotein E, ApoE, polymorphism), situational (loneliness), and individual factors (personality traits). To do this, a group of healthy older people over 55 years of age, men and women, were evaluated. A neuropsychological battery was ad…
Loneliness in adult people: its relationships with stress, health and hypothalamic-pituitary-adrenal axis functioning
2022
El sentiment de solitud és un dels principals problemes de les societats occidentals. En els últims anys els avanços en internet ens han portat a ser una societat més connectada que mai, a pesar d’açò, aquest sentiment s’està incrementant. Per sobreviure i prosperar, els éssers humans necessitem dels altres per satisfer les necessitats d’afecte, pertinença i reconeixement. D’aquesta manera, la solitud sorgeix de la discrepància entre les relacions íntimes i socials desitjades i les reals. La investigació indica que la solitud està relacionada amb l’estrès i amb diverses conseqüències en la salut tant física com psicològica. Aquesta es pot experimentar al llarg de la vida, encara que és més …