Search results for "Adult"
showing 10 items of 17453 documents
Oral contraceptives in the prevention of endometrioma recurrence: does the different progestins used make a difference?
2013
""The primary aim of the study was to analyze the endometrioma recurrence rate in patients who underwent laparoscopic excision followed by postoperative long-term regimen of oral contraceptives (OCs).. . MATERIALS AND METHODS: 168 patients who underwent a conservative laparoscopic surgery for endometrioma, during the period between September 2009 and August 2010 in three university hospitals were studied. A long-term OCs therapy was offered to all women following surgery. Patients were randomly divided into three groups according to different progestins used (desogestrel, gestodene, dienogest). Women who refused a postoperative hormonal therapy served as control. Follow-up visits and transv…
Continuous subcutaneous Insulin infusion leads to immediate, table, and long-term changes in metabolic control
2008
Background: Evaluations of continuous subcutaneous insulin infusion (CSII) usually focus on one pre- and one post-CSII measurement to assess metabolic therapy outcome. Aim: Extending this research, the aim of the present study was to provide a more fine-grained analysis of achieved glycaemic control. Methods: In 52 patients with type 1 diabetes (mean age of 37.85 years at CSII begin; s.d. ± 12.41), haemoglobin A1c (HbA1c) levels were assessed every 3 months over a period of 5 years (1 year before and 4 years after the introduction of CSII). Mixed models were utilized to describe changes in glycaemic control. Results: The pre–post course showed that already in the first quarter, a statis…
Teenage motherhood and the evaluation of relationships in the family of origin in mothers in their early adulthood
2019
BackgroundThe objective of this study was to evaluate the relationships in the family of origin in a sample of mothers who had their first child as teenagers (off-time motherhood). We also sought to answer the following question: are there any differences in the evaluation of relationships between mothers who gave birth to their first child in their teens and those who had their first baby during women’s best fertility age (on-time motherhood)? For women, the optimum reproductive age is anywhere between 20 and 30 years of age.Participants and procedureThe study looked at 60 mothers, including 30 off-time mothering and 30 on-time mothering. Two research tools were used in the study: an own s…
Lifelong learning and the English language : the significance of studying English voluntarily at adult age
2014
Opiskelu ja tietoinen oppiminen ovat yhä tärkeämpiä asioita aikuisten elämässä. Elinikäinen oppiminen tarjoaa välineitä, joilla aikuiset pystyvät vastaamaan haasteisiin, joita globaali ja nopeasti muuttuva maailma tarjoaa. Kieli- ja viestintätaitojen kehittäminen aikuisiällä on yksi elinikäisen oppimisen muoto. Tämän tutkimuksen tarkoituksena oli selvittää millaisia merkityksiä aikuisopiskelijat antavat aikuisiässä tapahtuville omaehtoisille englannin kielen opinnoilleen sekä millainen rooli englannin kielellä on kyseisten opiskelijoiden elämässä. Tutkimuksessa selvitettiin aikuisopiskelijoiden syitä osallistua Englannin kielen kursseille ja näiden syiden kautta tutkittiin myös opiskelijoid…
Socio-Demographic Vulnerability of Youth
2008
For a kind of inertia effect, the Italian welfare state protects today the old age too intensely while little the new risks associated with other phases of life course. Young Italians seem to suffer the actual changes: “youth remain longer in parental home and postpone the creation of its own independent life to most advanced age”. To understand the vulnerability situation increasingly widespreading among young people, it seems more and more necessary the depth analysis of the reasons and the subjective status of this discomfort that occur through a delay in transition to adulthood. In particular we study the self-perceived vulnerability situation of young Italians in the labor market (both…
Does δ-sarcoglycan-associated autosomal-dominant cardiomyopathy exist?
2009
In this study we clinically and genetically characterize a consanguineous family with a homozygous novel missense mutation in the delta-sarcoglycan gene and a second delta-sarcoglycan mutation that has previously been reported to cause severe autosomal-dominant dilated cardiomyopathy. We identified a novel missense mutation in exon 6 (p.A131P) of the delta-sarcoglycan gene, which in a homozygous state leads to the clinical picture of a limb girdle muscular dystrophy. In four heterozygous carriers for the mutation, aged 3-64 years, a second sequence variant in exon 6 (p.S151A) of the delta-sarcoglycan gene was detected on the other allele. This second missense change had previously been repo…
HLA-B27-restricted T cells from patients with ankylosing spondylitis recognize peptides from B*2705 that are similar to bacteria-derived peptides
2003
SUMMARY Ankylosing spondylitis (AS) is an inflammatory systemic disease affecting the spine, sacroiliacal and peripheral joints. Although the aetiology of AS remains unknown, the strong association with the HLA-B27 allele might reflect directly a detrimental effect of the HLA-B27 molecule itself, resulting from its potential capability to present ‘arthritogenic’ peptides to CD8+ T cells. Because some forms of SpA are triggered by enterobacterial infection, such arthritogenic peptides might originate from autologous and/or bacterial proteins triggering cross-reactive CD8+ T cell clones. Intriguingly, two peptides from the second extracellular domain of HLA-B*2705 share sequence homologies wi…
The migration of femoral components after total hip replacement surgery: accuracy and precision of software-aided measurements.
2003
To assess the accuracy and precision of a software-aided system to measure migration of femoral components after total hip replacement (THR) on digitised radiographs.Subsidence and varus-valgus tilt of THR stems within the femur were measured on digitised anteroposterior pelvic radiographs. The measuring software (UMA, GEMED, Germany) relies on bony landmarks and comparability parameters of two consecutive radiographs. Its accuracy and precision were calculated by comparing it with the gold standard in migration measurements, radiostereometric analysis (RSA). Radiographs and corresponding RSA measurements were performed in 60 patients (38-69 years) following cementless THR surgery.The UMA s…
Adalimumab in active ulcerative colitis: A “real-life” observational study
2013
Abstract Background and aims The effectiveness of adalimumab in the treatment of ulcerative colitis is under debate. Although controlled trials have shown that adalimumab is significantly better than placebo, the absolute clinical benefit is modest. We report data on the effectiveness of adalimumab in a cohort of ulcerative colitis patients treated in 22 Italian centres. Methods All patients with active disease treated with adalimumab were retrospectively reviewed. Co-primary endpoints were clinical remission at weeks 4, 12, 24 and 54. Secondary endpoints were sustained clinical remission, steroid discontinuation, endoscopic remission and need for colectomy. Results Eighty-eight patients we…
Pfeiffer syndrome: clinical and genetic findings in five Brazilian families
2014
Pfeiffer syndrome (PS) is mainly characterized by craniosysnostosis, midface hypoplasia, great toes with partial syndactyly of the digits and broad and medially deviated thumbs. It is caused by allelic mutations in the fibroblast growth factor receptor 1 and 2 (FGFR1 and 2) genes. This study describes the clinical and genetic features of five Brazilian families affected by PS. All patients exhibited the classical phenotypes related to PS. The genetic analysis was able to detect the mutations Cys278Phe, Cys342Arg, and Val359Leu in three of these families. Two mutations were de novo, with one familial. We identified pathogenic mutations in four PS cases in five Brazilian families by PCR seque…