Search results for "Advanced"
showing 10 items of 750 documents
Strong Expression of Chemokine Receptor CXCR4 by Renal Cell Carcinoma Correlates with Advanced Disease
2008
Diverse chemokines and their receptors have been associated with tumor growth, tumor dissemination, and local immune escape. In different tumor entities, the level of chemokine receptorCXCR4 expression has been linked with tumor progression and decreased survival. The aim of this study was to evaluate the influence ofCXCR4 expression on the progression of human renal cell carcinoma.CXCR4 expression of renal cell carcinoma was assessed by immunohistochemistry in 113 patients. Intensity ofCXCR4 expression was correlated with both tumor and patient characteristics. Human renal cell carcinoma revealed variable intensities ofCXCR4 expression. StrongCXCR4 expression of renal cell carcinoma was si…
ADVANCED ENDOSCOPIC IMAGING FOR SURVEILLANCE FOR DYSPLASIA AND COLORECTAL CANCER IN INFLAMMATORY BOWEL DISEASE: COULD THE PATHOLOGIST BE FURTHER HELP…
2014
Patients with inflammatory bowel disease (IBD) have an increased risk of developing intestinal cancer. The magnitude of that increased risk as well as how best to mitigate it remain a topic of ongoing investigation in the field. It is important to quantify the risk of colorectal cancer in association with IBD. The reported risk varies widely between studies. This is partly due to the different methodologies used in the studies. Because of the limitations of surveillance strategies based on the detection of dysplasia, advanced endoscopic imaging and techniques involving the detection of alterations in mucosal antigens and genetic abnormalities are being investigated. Development of new bioma…
Cancer in the first 18 months of life
2020
Introduction: Oncological-haematological disease continues to be the first cause of non-traumatic mortality in childhood, as well as a significant cause of morbidity. The patient less than 18-months-old has special clinical, diagnostic, and therapeutic features that all paediatricians are interested in determining, with the aim of achieving greater survival and a lower morbidity throughout the lives of their patients. Material and methods: A retrospective, descriptive study was carried out using the clinical, diagnostic, and therapeutic variables in patients less than 18-months-old diagnosed with an oncological-haematological that received chemotherapy in a Paediatric Oncology Unit between …
A detector for CLIC: main parameters and performance
2019
Together with the recent CLIC detector model CLICdet a new software suite was introduced for the simulation and reconstruction of events in this detector. This note gives a brief introduction to CLICdet and describes the CLIC experimental conditions at 380 GeV and 3 TeV, including beam-induced backgrounds. The simulation and reconstruction tools are introduced, and the physics performance obtained is described in terms of single particles, particles in jets, jet energy resolution and flavour tagging. The performance of the very forward electromagnetic calorimeters is also discussed.
A Study of Gravitational Lens Chromaticity with the Hubble Space Telescope
2011
We report Hubble Space Telescope observations of 6 gravitational lenses with the Advanced Camera for Surveys. We measured the flux ratios between the lensed images in 6 filters from 8140\AA\ to 2200\AA. In 3 of the systems, HE0512$-$3329, B1600+434, and H1413+117, we were able to construct UV extinction curves partially overlapping the 2175\AA\ feature and characterize the properties of the dust relative to the Galaxy and the Magellanic Clouds. In HE1104$-$1804 we detect chromatic microlensing and use it to study the physical properties of the quasar accretion disk. For a Gaussian model of the disk $\exp(-r^2/2 r_s^2)$, scaling with wavelength as $r_s \propto \lambda^p$, we estimate $r_s(\l…
Upgrade of the ATLAS Level-1 Trigger with event topology information
2015
The Large Hadron Collider (LHC) in 2015 will collide proton beams with increased luminosity from \unit{10^{34}} up to \unit{3 \times 10^{34}cm^{-2}s^{-1}}. ATLAS is an LHC experiment designed to measure decay properties of high energetic particles produced in the protons collisions. The higher luminosity places stringent operational and physical requirements on the ATLAS Trigger in order to reduce the 40MHz collision rate to a manageable event storage rate of 1kHz while at the same time, selecting those events with valuable physics meaning. The Level-1 Trigger is the first rate-reducing step in the ATLAS Trigger, with an output rate of 100kHz and decision latency of less than 2.5$\mu s$. It…
Construction, Commissioning and First Results of a Highly Granular Hadron Calorimeter with SiPM-on-Tile Read-out
2018
The CALICE collaboration is developing a highly granular Analogue Hadron sampling CALorimeter (AHCAL) for a future electron-positron collider. Very small detection units are required for the AHCAL due to an optimized design for the Particle Flow Algorithm. This is realized with scintillator tiles each wrapped in reflector foil and individually read out by a silicon photomultiplier (SiPM). These scintillator tiles and SiPMs are assembled on readout boards (HCAL Base Unit, HBU) which are integrated later on in the AHCAL detector stack. With this design a higher energy resolution is achievable, but also a large quantity of components (around 8,000,000 scintillator tiles and SiPMs) are needed t…
A pedagogical approach to the Magnus expansion
2010
Time-dependent perturbation theory as a tool to compute approximate solutions of the Schrodinger equation does not preserve unitarity. Here we present, in a simple way, how the Magnus expansion (also known as exponential perturbation theory) provides such unitary approximate solutions. The purpose is to illustrate the importance and consequences of such a property. We suggest that the Magnus expansion may be introduced to students in advanced courses of quantum mechanics.
Advanced models for nonlocal magneto-electro-elastic multilayered plates based on Reissner mixed variational theorem
2019
In the present work, nonlocal layer-wise models for the analysis of magneto-electro-elastic multilayered plates are formulated. An Eringen non-local continuum behaviour is assumed for the layers material; in particular, as usual in plate theories, partial in-plane nonlocality is assumed whereas local constitutive behaviour is considered in the thickness direction. The proposed plate theories are obtained via the Reissner Mixed Variational Theorem, assuming the generalized displacements and generalized out-of-plane stresses as primary variables, and expressing them as through-the-thickness expansions of suitably selected functions, considering the expansion order as a free parameter. In the …
Case Studies of Macro-and Microplastics Pollution in Coastal Waters and Rivers: Is There a Solution With New Removal Technologies and Policy Actions?.
2020
This opinion paper on microplastics pollution has selected different aspects and case studies of micro and macro-plastic litter pollution in coastal waters, and rivers. We point out a discussion on this topic and ask ourselves if there is a solution to the global problem by developing new microplastics removal technologies as well as policy actions. The first two case studies are related with macroplastics marine litter in beaches, a third report describes a new simple sampling device for microplastics in coastal and nearshore areas, five case study assess microplastics pollution in worldwide coastal environments, sediments and catchments (India, Mexico, Australia, Europe and the Nordic Sea…