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RESEARCH PRODUCT
Strong Expression of Chemokine Receptor CXCR4 by Renal Cell Carcinoma Correlates with Advanced Disease
Walburgis BrennerMartin R. BergerPeter R. GalleJörg SchadtStefan BiesterfeldThomas WehlerInes GockelMarkus MoehlerJoachim W. ThüroffCarl C. SchimanskiClaudine Grafsubject
Pathologymedicine.medical_specialtyChemokineArticle Subjectbiologybusiness.industrymedicine.diseaselcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensCXCR4lcsh:RC254-282Chemokine receptorOncologyTumor progressionRenal cell carcinomaAdvanced diseasebiology.proteinMedicineImmunohistochemistrybusinessReceptorResearch Articledescription
Diverse chemokines and their receptors have been associated with tumor growth, tumor dissemination, and local immune escape. In different tumor entities, the level of chemokine receptorCXCR4 expression has been linked with tumor progression and decreased survival. The aim of this study was to evaluate the influence ofCXCR4 expression on the progression of human renal cell carcinoma.CXCR4 expression of renal cell carcinoma was assessed by immunohistochemistry in 113 patients. Intensity ofCXCR4 expression was correlated with both tumor and patient characteristics. Human renal cell carcinoma revealed variable intensities ofCXCR4 expression. StrongCXCR4 expression of renal cell carcinoma was significantly associated with advanced T-status (P=.039), tumor dedifferentiation (P= .0005), and low hemoglobin (P= .039). In summary, strongCXCR4 expression was significantly associated with advanced dedifferentiated renal cell carcinoma.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-12-01 | Journal of Oncology |