Search results for "African"
showing 10 items of 334 documents
Termini Imerese (PA) [Sito 88]
2016
This work will examine the imports of African pottery at Termae Himeraeae, pointing to the atelier of origin and identifying local imitations of African types, according to archaeometrical analyses.
Wole Soyinka: Due Poesie
2008
Durante l'undicesima edizione del Festivaletteratura di Mantova, nel settembre 2007, Wole Soyinka, insieme alla studiosa e traduttrice Alessandra Di Maio, ha ripercorso la sua carriera poetica, spiegandone svolte e sviluppi. In questa sede si riportano due delle sue poesie più note in traduzione -- "Conversazione telefonica" e "I figli di questa terra" -- che coprono idealmente l'arco della sua produzione poetica, dalla gioventù all'eta matura.
International solidarity in the GDR and transnationality: an analysis of primary school materials for Namibian child refugees
2014
As part of a solidarity project between the South West African People’s Organization (SWAPO) and the German Democratic Republic (GDR), approximately 430 Namibian children were brought to the GDR from 1979 to 1989 to be trained as an elite for a future liberated Namibia. The children attended school in the GDR until they were brought back to Namibia in August 1990. The school lessons intertwined topics about Namibia and SWAPO with the usual GDR school curriculum. The linchpin of this intertwining was the socialist ideal of international solidarity. This article uses an objective-hermeneutic analysis to show how the school materials produced transnationality.
Meanings of travel in the musical discourse of blues: Roosevelt “Grey Ghost” Williams and “Lonesome Traveller”
2016
El objetivo de este artículo es investigar, desde una perspectiva comunicativa, socio-semiótica y etnomusicológica, la construcción de sentido sobre el viaje y el estilo de vida itinerante (hobo) en el discurso musical del blues. Primero realizaremos una contextualización histórica del viaje en la tradición afroamericana, y después analizaremos el caso del legendario músico texano Roosevelt «Grey Ghost» Williams (1903-1996) y de su composición «Lonesome Traveller» («viajero solitario»), en la que se representa el sujeto y estilo de vida hobo (trabajador migrante y sin hogar). En ese proceso, discutiremos el sentido del viaje como imposición y el sentido del viaje como signo de independencia…
African trypanosomes expressing multiple VSGs are rapidly eliminated by the host immune system
2019
Significance Many parasites escape the host immune system by undergoing antigenic variation, a process in which surface antigens are regularly shed and replaced by new ones. Trypanosoma brucei employs multiple sophisticated molecular mechanisms to ensure the expression of a homogeneous VSG coat. We generated a mutant parasite that expresses multiple distinct VSGs and studied the consequences of having a multi-VSG coat during an infection. We showed that expression of multiple VSGs makes the parasites more vulnerable to the immune response, which can now control the trypanosomes from the onset of the infection, allowing most mice to survive. In the future, trypanosome infections may be treat…
Predicting 19F NMR Chemical Shifts: A Combined Computational and Experimental Study of a Trypanosomal Oxidoreductase–Inhibitor Complex
2020
Abstract The absence of fluorine from most biomolecules renders it an excellent probe for NMR spectroscopy to monitor inhibitor–protein interactions. However, predicting the binding mode of a fluorinated ligand from a chemical shift (or vice versa) has been challenging due to the high electron density of the fluorine atom. Nonetheless, reliable 19F chemical‐shift predictions to deduce ligand‐binding modes hold great potential for in silico drug design. Herein, we present a systematic QM/MM study to predict the 19F NMR chemical shifts of a covalently bound fluorinated inhibitor to the essential oxidoreductase tryparedoxin (Tpx) from African trypanosomes, the causative agent of African sleepi…
Optimization Strategy of Novel Peptide-Based Michael Acceptors for the Treatment of Human African Trypanosomiasis
2019
This paper describes an optimization strategy of the highly active vinyl ketone 3 which was recognized as a strong inhibitor of rhodesain of Trypanosoma brucei rhodesiense, endowed with a ksecond v...
Development of Novel Benzodiazepine-Based Peptidomimetics as Inhibitors of Rhodesain from Trypanosoma brucei rhodesiense.
2020
Starting from the reversible rhodesain inhibitors 1 a-c, which have Ki values towards the target protease in the low-micromolar range, we have designed a series of peptidomimetics, 2 a-g, that contain a benzodiazepine scaffold as a β-turn mimetic; they are characterized by a specific peptide sequence for the inhibition of rhodesain. Considering that irreversible inhibition is strongly desirable in the case of a parasitic target, a vinyl ester moiety acting as Michael-acceptor was introduced as the warhead; this portion was functionalized in order to evaluate the size of corresponding enzyme pocket that could accommodate this substituent. With this investigation, we identified an irreversibl…
Distribution et abondance des mouches piqueuses (Glossinidae, Stomoxys et Tabanidae) dans deux parcs nationaux du Gabon.
2015
11 pages; International audience; In order to minimize risks of pathogen transmission with the development of ecotourism in Gabon, a seasonal inventory has been performed in five contrasted biotopes in Ivindo (INP) and Moukalaba-Doudou (MDNP) National Parks. A total of 10,033 hematophagous flies were captured. The Glossinidae, with six different species identified, was the most abundant group and constitutes about 60% of the captured flies compared to the Stomoxys (6 species also identified) and Tabanidae with 28% and 12%, respectively. The Glossinidae showed a higher rate of capture in primary forest and in research camps. In INP, the Stomoxys showed a higher rate of capture in secondary f…
La protezione della fauna nella Repubblica Centrafricana: un caso sui generis di protezione ambientale in Africa
1996
L'articolo analizza il regime giuridico della protezione dell'ambiente nella Repubblica Centrafricana.