Search results for "African"

showing 10 items of 334 documents

Ethnic differences in serum lipoproteins and their determinants in South African women

2010

2712 Endocrinology Diabetes and Metabolismlow-density lipoprotein South African women10076 Center for Integrative Human Physiology10265 Clinic for Endocrinology and Diabetology570 Life sciences; biology610 Medicine & health1310 Endocrinology
researchProduct

The chemical composition of the aerial parts essential oil of Lonas annua (L.) Vines & Druce (Asteraceae)

2022

Lonas annua (L.) Vines & Druce (Asteraceae), commonly known as African Daisy or Yellow Ageratum is a rare therophyte native to northwestern Africa (Algeria, Morocco, and Tunisia) and Italy (Sicily and Sardinia). In the present study, the chemical composition of the essential oil from aerial parts of Lonas annua was analyzed by GC-MS. No one report has been previously published on the essential oil of this species. The results showed the presence of large quantity of two unusual metabolites 2,3-dihydrofarnesol (41.64%), and acenaphthene (36.18%). Chemotaxonomic considerations were carried out in order to confirm the phylogenetic reconstructions of Anthemideae.

3-dihydrofarnesolchemotaxonomyAfrican Daisycompositaevolatile compositionOrganic Chemistry2Plant ScienceBiochemistrysicilian floraacenaphtheneAnalytical ChemistryNatural Product Research
researchProduct

Äthiopische Grammatik: mit Paradigmen, Litteratur, Chrestomathie und Glossar

1886

Teksts vācu un etiopiešu valodā.

:HUMANITIES and RELIGION::Languages and linguistics::Other languages::Semitic languages [Research Subject Categories]Afro-Asiatic languagesEthio-Semitic languagesEtiopijas valodasÄthiopische SpracheEtiopiešu valoda - gramatika.:HUMANITIES and RELIGION::Languages and linguistics::Other languages::African languages [Research Subject Categories]Etiosemītu valodasÄthiopische Sprache - GrammatikEthiopian languages
researchProduct

Tectonic evolution of the Sicilian Thrust System (central Mediterranean)

2012

The Sicilian Thrust System (STS) is a south-verging (Africa-verging) fold-and-thrust belt including a Mesozoic-Paleogene sedimentary sequence. This thrust stack owes its origin to the deformation of pre-orogenic strata deposited in different palaeogeographic domains belonging to passive margins of the African plate. The STS was deformed during the Neogene, following the closure of the Tethys Ocean and the continental collision between the Sardo-Corso Block and the North Africa margins. The thrust pile was detached from the underlying basement during the Miocene-Pleistocene. The regional-scale structural setting recognized allows us to reconstruct the tectonic evolution of the STS as follows…

Accretionary wedgeContinental collisionSettore GEO/03 - Geologia StrutturaleextensionGeologythrustingAfrica margin depositsNeogeneTethys Oceanlanguage.human_languageaccretionary prismAfrican PlatePaleontologytectonicBasement (geology)Passive marginlanguagetectonicsSicilianSicilyGeologySeismologyAfrica margin deposit
researchProduct

Genome-Wide Association Studies of the PR Interval in African Americans.

2011

The PR interval on the electrocardiogram reflects atrial and atrioventricular nodal conduction time. The PR interval is heritable, provides important information about arrhythmia risk, and has been suggested to differ among human races. Genome-wide association (GWA) studies have identified common genetic determinants of the PR interval in individuals of European and Asian ancestry, but there is a general paucity of GWA studies in individuals of African ancestry. We performed GWA studies in African American individuals from four cohorts (n = 6,247) to identify genetic variants associated with PR interval duration. Genotyping was performed using the Affymetrix 6.0 microarray. Imputation was p…

AdultMaleCancer ResearchMuscle ProteinsSingle-nucleotide polymorphismGenome-wide association studyQH426-470030204 cardiovascular system & hematologyBiologyGenetics and Genomics/Complex TraitsPolymorphism Single NucleotideSodium ChannelsWhite PeopleNAV1.5 Voltage-Gated Sodium ChannelNAV1.8 Voltage-Gated Sodium Channel03 medical and health sciencesElectrocardiography0302 clinical medicineAsian PeopleCardiovascular Disorders/Arrhythmias Electrophysiology and PacingGeneticsSNPHumansCardiac and Cardiovascular SystemsPR intervalInternational HapMap ProjectMyeloid Ecotropic Viral Integration Site 1 ProteinMolecular BiologyGenotypingGenetics (clinical)Ecology Evolution Behavior and Systematics030304 developmental biologyAgedGeneticsHomeodomain Proteins0303 health sciencesArrhythmias CardiacHeart-rate;Atherosclerosis risk; Genetic-analysis; Common variants; Design; Populations; Objectives; Conduction; Disease; TwinsMiddle AgedNeoplasm ProteinsMinor allele frequencyBlack or African AmericanAtrioventricular NodeFemaleT-Box Domain ProteinsImputation (genetics)Research ArticleGenome-Wide Association Study
researchProduct

Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci

2012

To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale meta-analyses by using a custom ∼50,000 SNP genotyping array (the ITMAT-Broad-CARe array) with ∼2000 candidate genes in 39 multiethnic population-based studies, case-control studies, and clinical trials totaling 17,418 cases and 70,298 controls. First, meta-analysis of 25 studies comprising 14,073 cases and 57,489 controls of European descent confirmed eight established T2D loci at genome-wide significance. In silico follow-up analysis of putative association signals found in independent genome-wide association studies (including 8,130 cases and 38,987 controls) performed by the DIAGRAM consortium id…

AdultMaleCandidate geneSNP ARRAYAdolescentGenotypeSUSCEPTIBILITY LOCI030209 endocrinology & metabolismGenome-wide association studySingle-nucleotide polymorphismLocus (genetics)BLOOD-PRESSUREBiologyPolymorphism Single NucleotideArticleYoung Adult03 medical and health sciences0302 clinical medicineEthnicityGeneticsHumansEUROPEAN AMERICANSGenetic Predisposition to DiseaseRESOURCE CAREGenetics(clinical)GENOME-WIDE ASSOCIATIONGenetics (clinical)Aged030304 developmental biologyGenetic associationAged 80 and overGeneticsAFRICAN-AMERICANS0303 health sciencesINSULIN-RESISTANCECOMMON VARIANTSMiddle Aged3. Good healthSNP genotypingDiabetes Mellitus Type 2Genetic LociCase-Control StudiesRISK-FACTORSFemaleTCF7L2Follow-Up StudiesGenome-Wide Association StudySNP array
researchProduct

Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia

2013

Increased systemic levels of myeloperoxidase (MPO) are associated with the risk of coronary artery disease (CAD). To identify the genetic factors that are associated with circulating MPO levels, we carried out a genome-wide association study (GWAS) and a gene-centric analysis in subjects of European ancestry and African Americans (AAs). A locus on chromosome 1q31.1 containing the complement factor H (CFH) gene was strongly associated with serum MPO levels in 9305 subjects of European ancestry (lead SNP rs800292; P = 4.89 × 10(-41)) and in 1690 AA subjects (rs505102; P = 1.05 × 10(-8)). Gene-centric analyses in 8335 subjects of European ancestry additionally identified two rare M…

AdultMaleGenotypeLocus (genetics)Single-nucleotide polymorphismGenome-wide association studyCoronary Artery Disease030204 cardiovascular system & hematologyBiologyPolymorphism Single NucleotideGene Expression Regulation EnzymologicWhite PeopleYoung Adult03 medical and health sciences0302 clinical medicineGenotypeGeneticsHumansSNPMolecular BiologyGenetic Association StudiesGenetics (clinical)AgedPeroxidase030304 developmental biology0303 health sciencesAssociation Studies ArticlesCase-control studyGenetic VariationGeneral MedicineMiddle Aged3. Good healthBlack or African AmericanCase-Control StudiesComplement Factor HFactor HMyeloperoxidaseImmunologybiology.proteinFemaleGenome-Wide Association StudyHuman Molecular Genetics
researchProduct

Associations between leprosy and serum protein groups

1970

Serum protein group typings were done on a sample of n=173 adult healthy Negroes from the Macua tribe in Mozambique and on n=129 leprous individuals from the same tribe. Unfortunately, the type of leprosy is not known. Whilst between leprosy and haptoglobins, transferrins and Pi proteins no associations could be observed, statistically significant associations between leprosy and ceruloplasmin resp. β2 I were found. It is pointed out that these associations should be confirmed by further research on other populations and with respect to type and process of leprosy, until biological and population genetical interpretations will be possible.

AdultMalePopulationSerum proteinBlack PeopleTribe (biology)LeprosyGeneticsmedicineHumansAlleleMetabolic diseaseeducationAllelesMozambiqueGenetics (clinical)Glycoproteinseducation.field_of_studyHaptoglobinsbiologyHaptoglobinTransferrinCeruloplasminfood and beveragesmedicine.diseaseBlack or African AmericanGenetics PopulationPhenotypeImmunologyBlood Group Antigensbiology.proteinFemaleLeprosyTrypsin InhibitorsCeruloplasminHuman Genetics
researchProduct

PTCH-1 and MDM2 expression in ameloblastoma from a West African sub-population: implication for chemotherapeutics

2015

INTRODUCTION: ameloblastoma is a slow growing, painless odontogenic swelling which can attain sizes that result in severe deformities of the craniofacial complex. It is the most commonly encountered odontogenic tumor in Nigeria. Surgical intervention is currently the method of treatment; however identification of altered molecular pathways may inform chemotherapeutic potential. The Protein Patched homolog 1 (PTCH-1) is overexpressed in ameloblastoma. Also, mutation in the MDM2 gene can reduce the tumor suppressor function of p53 and promote ameloblastoma growth. No study however has characterized the molecular profile of African cases of ameloblastoma with a view to developing chemotherapeu…

AdultMalemdm2Pathologymedicine.medical_specialtyPopulationNigeriaPathology and Forensic MedicinePTCH-1 MdM2 ameloblastoma chemotherapeuticsameloblastomaptch-1HumansMedicineRadiology Nuclear Medicine and imagingDentistry (miscellaneous)ddc:610educationAmeloblastomaStellate reticulumProtein Patched Homolog 1education.field_of_studylcsh:R5-920biologybusiness.industryResearchlcsh:Public aspects of medicinechemotherapeuticsOdontogenic tumorProto-Oncogene Proteins c-mdm2lcsh:RA1-1270General Medicinemedicine.diseaseJaw NeoplasmsGene Expression Regulation NeoplasticPatched-1 ReceptorWest africanstomatognathic diseasesMutationMonoclonalCancer researchbiology.proteinMdm2FemaleSurgeryOral SurgeryAntibodybusinesslcsh:Medicine (General)The Pan African Medical Journal
researchProduct

3D geometric morphometric analysis of variation in the human lumbar spine

2019

[Objectives]: The shape of the human lumbar spine is considered to be a consequence of erect posture. In addition, several other factors such as sexual dimorphism and variation in genetic backgrounds also influence lumbar vertebral morphology. Here we use 3D geometric morphometrics (GM) to analyze the 3D morphology of the lumbar spine in different human populations, exploring those potential causes of variation.

AdultMalemusculoskeletal diseasesMediterranean CaucasianAdolescentLordosisSouth AfricanPopulationBlack Peoplepopulation variationLumbar vertebraeBiologylordosisWhite PeopleAnthropology PhysicalSouth AfricaYoung AdultImaging Three-DimensionalLumbarmedicineHumansIsraeleducationAgedMorphometricseducation.field_of_studyLumbar VertebraeGeneralized Procrustes analysisAnatomyMiddle Agedmedicine.diseaseSexual dimorphismmedicine.anatomical_structureSpainAnthropologysexual dimorphismLordosisFemaleAnatomyTomography X-Ray ComputedVertebral column
researchProduct