Search results for "Ageing"
showing 10 items of 609 documents
Serine- and Threonine/Valine-Dependent Activation of PDK and Tor Orthologs Converge on Sch9 to Promote Aging
2014
Dietary restriction extends longevity in organisms ranging from bacteria to mice and protects primates from a variety of diseases, but the contribution of each dietary component to aging is poorly understood. Here we demonstrate that glucose and specific amino acids promote stress sensitization and aging through the differential activation of the Ras/cAMP/PKA, PKH1/2 and Tor/S6K pathways. Whereas glucose sensitized cells through a Ras-dependent mechanism, threonine and valine promoted cellular sensitization and aging primarily by activating the Tor/S6K pathway and serine promoted sensitization via PDK1 orthologs Pkh1/2. Serine, threonine and valine activated a signaling network in which Sch…
Impact of Chaperonopathies in Protein Homeostasis and Beyond
2013
Chaperones have functions other than those classically attributed to them pertaining to protein homeostasis. These “other” non-canonical functions are the focus of chapter 8. The close interaction of the chaperoning and the immune systems and the impact of their malfunctioning on aging and cancer are highlighted. Conversely, the impact of ageing and cancer on the two systems is also underscored. The connections between stress, protein damage (including chaperones), protein misfolding, protein aggregation and precipitation, and tissue degeneration, are analyzed, indicating that all these processes are aggravated by a decline in chaperoning potential with aging (chaperonopathies of the aged) …
Smart Technologies for the Environmental Design of Smaller Urban Centres
2020
The present study focuses on welfare measures and specifically on healthcare. The challenge we would like to accept is to provide efficient healthcare to residents in an isolated area without health services, maintaining the same level of healthcare ensured by hospitals. The innovative design, that we want to experience, is closely linked to the use of ICT, information and communication technologies, because these technologies would be able to perform autonomously multiple functions, using remote control. Telemedicine or “virtual health” is a particular branch of ICT that can improve future quality of living in a marginal urban center as a tool to ensure prompt access to expert advice, as w…
How Can We Integrate Life Course Vaccination into the New WHO Definition of “Healthy Ageing”?
2019
The first global report on health and ageing published by the World Health Organization (WHO) in 2015 introduced a new and innovative concept, namely, the idea that healthy ageing encompasses more than just the absence of disease. The report considered healthy ageing to be a more holistic process of developing and maintaining the functional ability that enables well-being in older age. There are two major components to this concept, namely, personal and environmental determinants of ageing. Personal determinants of ageing correspond to our intrinsic capacity, including our genetic inheritance, personal characteristics, health-related behaviours, and risk factors. Living our daily lives in g…
Lifelong education
2016
In a society where population aging is a very present reality, it is urgent the adaptation of social policies and strategies for promoting the well-being of this age group [7]. Learning lifelong and adult education are strategies that aim to achieve social, cultural and economic development [4]. They are, undoubtedly, strategies that have a positive impact on society. Intergenerational learning is a practice that allows us to include not only the older, as far as the younger population, benefiting from this strategy two disparate generations. Learning throughout life, through intergenerational sociability, has added value, encourages the closeness between the generations: the younger ones, …
Global prevalence and genotype distribution of hepatitis C virus infection in 2015:a modelling study
2017
WOS: 000426979400014
1H NMR Spectroscopy with Multivariate Statistical Analysis as a Tool for a Rapid Screening of the Molecular Changes Occurring During Micro-Oxygenatio…
2008
A red wine from Aglianico vine was subjected to a micro-oxygenation procedure for five weeks. The wine was weekly sampled together with a non micro-oxygenated control and extracted with di-ethyl-ether in order to simplify NMR analyses. In fact, 1 H NMR spectra of the whole wine samples were dominated by water and ethanol signals which pre- vented visibility of the resonances generated by the less concentrated wine components. The 1 H NMR analyses of the di- ethyl-ether extracts revealed an increase of the amount of oxygen-containing materials. Such increase was attributed to a wine ageing process which resulted, hence, fastened by application of micro-oxygenation.
Surface properties of Saccharomyces cerevisiae lees during sparkling wine ageing and their effect on flocculation
2009
Cell surface properties were determined for the first time for lees of Saccharomyces cerevisiae, and they proved to be significantly dependent on the time of sparkling wine ageing on lees. Cell surface hydrophobicity decreased from approximately 44% to 11% of affinity to hexadecane. Electron acceptor capacity (calculated as % affinity to ethyl acetate-% affinity to decane) increased from approximately -27% to 10 % and zeta potential from approximately -4 to 6mV. Mannoproteins are released from the external cell wall layer during the autolytic process, as confirmed by TOF-SIMS analysis of the cell wall chemical composition. This could explain the modifications of lees cell surface properties…
Ageing of isotactic polypropylene due to morphology evolution, experimental limitations of realtime density measurements with a gradient column
2006
Abstract Ageing in crystalline polymers is responsible for the deterioration of physical properties leading, for example, to a decrease in toughness and to dimensional changes that are to some extent responsible for warpage and scrap production in injection molding. Since, it depends on the mutual transformation of stable and metastable phases, being always related to changes in morphological organization, it is here preferred to call it ‘Morphological ageing’. Although, one would expect the ageing regime to be determined by the complex morphology with amorphous phases of different mobility and eventually multiple crystalline phases, transformed into each other at an associated transition, …
Manufacturing and characterization of single cell intermediate-temperature solid oxide fuel cells for APU in transportation application
2014
The fabrications of large area IT-SOFC planar cell by new simple and cost effective process were explained. The optimization of the new process with respect to pore formers, thickness of layers, sintering temperature were performed. The electrochemical results of 10cm2 performed in Fiaxell open flange set up were detailed with respect to different configuration. Long term ageing performance tests of single cells were conducted in Fiaxell device and results are discussed. Preparation of new test bench and stacking process performed till now were briefed.