Search results for "AhR"
showing 10 items of 75 documents
Between Two Worlds. German Travellers in Spain and Morocco in the 19th Century
2014
La literatura de viajes, como vehículo privilegiado para documentar relaciones interculturales, es rica en diferentes expresiones y ejemplos de tipología analógica, antitética y recíproca, que resaltan las similitudes y las diferencias entre la nación propia y la extraña. En el caso de los viajeros alemanes cuyo destino era originariamente España, pero que luego, por diversos motivos, también visitaron Marruecos, la percepción de diferencias suele ser doble, como intentaremos mostrar en el siguiente artículo. En la tipología presente en estos relatos de viaje, España funciona como punto de partida. La tipología analógica y la recíproca apenas se dan, ya que Alemania como país de origen suel…
Pasaules spogulis
1599
Teoloģiski, filozofiski ētisks un vēsturisks traktāts, viens no apjomīgākajiem N. Molllīna iespieddarbiem. Izdots arī latīņu valodā (1588, 1599). Vācu valodas izdevums dāvāts Livonijas karavadonim dažādu valstu karadienestā Georgam Fārensbaham (1551-1602), Cēsu pirmajam vaivadam no 1598. gada līdz 1602. gadam, kad krita karā pret zviedriem aplencot Vīlandes pili. Grāmatas titullapu ietver ornamentāla aproce ar dažādām fantastiskām būtnēm, grifiem, jūras vāravām utml. Ievadā publicēta Dāvida Hilhena vēstule Georgam Cīgleram. Tad seko Dāniela Hermaņa sacerētais Georga Fārensbaha dzīves apraksts. Šis G. Cīglera darbs ir vienīgais Mollīna iespieddarbs, kas guvis plašāku ievērību ārpus Livonijas…
Transcriptional profiling of rat hypothalamus response to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin
2015
In some mammals, halogenated aromatic hydrocarbon (HAH) exposure causes wasting syndrome, defined as significant weight loss associated with lethal outcomes. The most potent HAH in causing wasting is 2,3,7,8-tetrachlorodibenzo-r-dioxin (TCDD), which exerts its toxic effects through the aryl hydrocarbon receptor (AHR). Since TCDD toxicity is thought to predominantly arise from dysregulation of AHR-transcribed genes, it was hypothesized that wasting syndrome is a result of to TCDD-induced dysregulation of genes involved in regulation of food-intake. As the hypothalamus is the central nervous systems' regulatory center for food-intake and energy balance. Therefore, mRNA abundances in hypothala…
Cross-species transcriptomic analysis elucidates constitutive aryl hydrocarbon receptor activity
2014
Background Research on the aryl hydrocarbon receptor (AHR) has largely focused on variations in toxic outcomes resulting from its activation by halogenated aromatic hydrocarbons. But the AHR also plays key roles in regulating pathways critical for development, and after decades of research the mechanisms underlying physiological regulation by the AHR remain poorly characterized. Previous studies identified several core genes that respond to xenobiotic AHR ligands across a broad range of species and tissues. However, only limited inferences have been made regarding its role in regulating constitutive gene activity, i.e. in the absence of exogenous ligands. To address this, we profiled transc…
Use of high flow nasal cannula in patients with acute respiratory failure in general wards under intensivists supervision: a single center observatio…
2022
Abstract Background Few data exist on high flow nasal cannula (HFNC) use in patients with acute respiratory failure (ARF) admitted to general wards. Rationale and objectives To retrospectively evaluate feasibility and safety of HFNC in general wards under the intensivist-supervision and after specific training. Methods Patients with ARF (dyspnea, respiratory rate-RR > 25/min, 150 < PaO2/FiO2 < 300 mmHg during oxygen therapy) admitted to nine wards of an academic hospital were included. Gas-exchange, RR, and comfort were assessed before HFNC and after 2 and 24 h of application. Results 150 patients (81 male, age 74 [60–80] years, SOFA 4 [2–4]), 123 with de-novo ARF underwent HFNC wi…
Transcriptional profiling of rat white adipose tissue response to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin
2015
Polychlorinated dibenzodioxins are environmental contaminants commonly produced as a by-product of industrial processes. The most potent of these, 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD), is highly lipophilic, leading to bioaccumulation. White adipose tissue (WAT) is a major site for energy storage, and is one of the organs in which TCDD accumulates. In laboratory animals, exposure to TCDD causes numerous metabolic abnormalities, including a wasting syndrome. We therefore investigated the molecular effects of TCDD exposure on WAT by profiling the transcriptomic response of WAT to 100 mu g/kg of TCDD at 1 or 4 days in TCDD-sensitive Long-Evans (Turku/AB; L-E) rats. A comparative analysi…
Teacher trainees' experiences of the components of ICT competencies and key factors in ICT competence development in work-based vocational teacher tr…
2022
International journal for research in vocational education and training 9 (2022) 2, S. 146-166
Brief an Karl Axel Christer Freiherr von Bruiningk
1839
Ms. 930a, Nr. 6b, Bl. 19r-19v Merkel, Garlieb H. Brief an Karl Axel Christer Freiherr von Bruiningk, [Depkinshof ?], [bez datuma; ohne Datum, pēc / nach 1839] Autora rokraksts / Autograph, vācu val. / Deutsch, [2] lpp. / S. Attēlu numuri / Bildnummern: 930a-006b-1 – 930a-006b-2 In dem undatierten Entwurf einer Antwort auf einen Brief Bruiningks [womit der unter Ms. 930a, Nr. 6a gemeint wird, bleibt noch unklar] lobt Merkel dessen Einsatz für die Bauernbefreiung. Das Problem des fehlenden Grundbesitzes für die freigelassenen Bauern sei ein Grund für die wirtschaftliche Rückständigkeit der „vaterländische[n] Provinzen“. Selbst in Posen (Preußen) und Galizien (Österreich) hätte die wirtschaftl…
Sentieri interrotti. Musicisti europei nel crepuscolo dell'Occidente
2012
Il volume descrive il contesto in cui vedono la luce le due mostre dedicate all’Arte Degenerata (Monaco 1937) e alla Musica Degenerata (Düsseldorf 1938), soffermandosi in modo particolare sui percorsi biografici e artistici di quattro compositori la cui biografia venne sconvolta dalla politica culturale nazista: Franz Schreker, Alexander Zemlinsky, Erich Wolfgang Korngold e Viktor Ullmann. Si tratta di autori di origine ebraica, legati in vario modo alla vita musicale di città come Berlino, Vienna e Praga, assai diversi per formazione e linguaggio, ma tutti travolti da una serie di eventi (l'avvento al potere di Hitler, la guerra, la Shoah) che trasformarono i loro percorsi biografici in al…
Brief an Garlieb H. Merkel
1799
Ms. 930a, Nr. 8, Bl. 22r-23v Böttiger, Karl August. Brief an Garlieb H. Merkel, Weimar, d[en] 13. November 1797 Autora rokraksts / Autograph, vācu, angļu un latīņu val. / Deutsch, Englisch und Latein [4] lpp. / S. Attēlu numuri / Bildnummern: 930a-008-1 – 930a-008-4 Der Verfasser nennt in diesem inhaltsreichen Brief zahlreiche Namen und hält nicht nur die Verbindung mit Merkel, die aus dessen erstem Aufenthalt in Weimar resultierte, aufrecht, sondern gibt ihm weitere Hinweise und Empfehlung für seinen weiteren Aufenthalt in Dänemark. So rät er zur Übersetzung dreier Romane aus dem Englischen, darunter Jane Wests „A gossip's story“ (London 1796). Ferner bittet der Verfasser Merkel um Gefälli…