Search results for "Aide"
showing 10 items of 1461 documents
Introducing a novel mesh following technique for approximation-free robotic tool path trajectories
2017
Abstract Modern tools for designing and manufacturing of large components with complex geometries allow more flexible production with reduced cycle times. This is achieved through a combination of traditional subtractive approaches and new additive manufacturing processes. The problem of generating optimum tool-paths to perform specific actions (e.g. part manufacturing or inspection) on curved surface samples, through numerical control machinery or robotic manipulators, will be increasingly encountered. Part variability often precludes using original design CAD data directly for toolpath generation (especially for composite materials), instead surface mapping software is often used to gener…
Optimization of fluorescence enhancement for silicon-based microarrays
2008
An optical technique for the enhancement of fluorescence detection sensitivity on planar samples is presented. Such a technique is based on the simultaneous optimization of excitation and light collection by properly combining interference and reflectance from the sample holder. Comparative tests have been performed in microarray applications, by evaluating the proposed solution against commercial glass-based devices, using popular labeling dyes, such as Cy3 and Cy5. The proposed technique is implemented on a substrate built with standard silicon technology and is therefore well suited for integrated micro total analysis systems (microTAS) applications.
QSAR methods for the discovery of new inflammatory bowel disease drugs
2013
Inflammatory bowel disease (IBD) represents an important class of chronic gastrointestinal tract disease. And although there are already several useful treatments to reduce and control the symptoms, there is still no cure. One drug discovery technique used is the computer-aided (in silico) discovery approach which has largely demonstrated efficacy. Computational techniques, when used in combination with traditional drug discovery methodology, greatly increase the chance of drug discovery in a sustainable and economical fashion.This review aims to provide the most recent and important advances of in silico IBD drug discovery. While this review is mainly focused on QSAR methods, especially th…
Molecular topology as a novel approach for drug discovery
2012
Molecular topology (MT) has emerged in recent years as a powerful approach for the in silico generation of new drugs. One key part of MT is that, in the process of drug design/discovery, there is no need for an explicit knowledge of a drug's mechanism of action unlike other drug discovery methods.In this review, the authors introduce the topic by explaining briefly the most common methodology used today in drug design/discovery and address the most important concepts of MT and the methodology followed (QSAR equations, LDA, etc.). Furthermore, the significant results achieved, from this approach, are outlined and discussed.The results outlined herein can be explained by considering that MT r…
Highly stable Zerodur based optical benches for microgravity applications and other adverse environments
2019
A number of cold atom experiments are restrained by the impeding effects of gravity. While efforts have been made to overcome these limitations in a gravitational environment, another approach is placing the experiment in a microgravity environment, as can be found aboard sounding rockets, satellites or a space station. The cornerstone of such experiments is a robust laser system. The adverse conditions during a rocket launch impose stringent requirements on thermal stability and resilience against mechanical stress on this part of the experimental setup. Furthermore, the very limited space found on any of the aforementioned microgravity platforms necessitates maximal miniaturization. In or…
Generation of narrowband antisymmetric lamb waves using a formed laser source in the ablative regime
2007
A formed laser source, using a four-element lenticular array, is used in the ablative regime to generate select, narrowband, acoustic plate waves. The arrangement of the array produces acoustical signals that have frequencies compatible with the response of the broadband capacitive air-coupled transducer used in this study. A simplified concept is presented to explain the effect of a line array source on the frequency content of acoustic waves. The analytical model for a point pulse surface displacement is derived from the point load solution to Lamb's problem. The point pulse displacement elements of a line array source are summed mathematically, taking into account all applicable propagat…
CAD of complex passive devices composed of arbitrarily shaped waveguides using Nyström and BI-RME methods
2004
In this paper, a novel computer-aided design (CAD) tool of complex passive microwave devices in waveguide technology is proposed. Such a tool is based on a very efficient integral-equation analysis technique that provides a full-wave characterization of discontinuities between arbitrarily shaped waveguides defined by linear, circular, and/or elliptical arcs. For solving the modal analysis of such arbitrary waveguides, a modified version of the well-known boundary integral-resonant-mode expansion (BI-RME) method using the Nyström approach, instead of the traditional Galerkin version of the method of moments, is proposed, thus providing significant savings on computational costs and implement…
A Novel Approach of a Low-Cost UWB Microwave Imaging System with High Resolution Based on SAR and a New Fast Reconstruction Algorithm for Early-Stage…
2022
In this article, a new efficient and robust approach—the high-resolution microwave imaging system—for early breast cancer diagnosis is presented. The core concept of the proposed approach is to employ a combination of a newly proposed delay-and-sum (DAS) algorithm and the specific absorption rate (SAR) parameter to provide high image quality of breast tumors, along with fast image processing. The new algorithm enhances the tumor response by altering the parameter referring to the distance between the antenna and the tumor in the conventional DAS matrices. This adjustment entails a much clearer reconstructed image with short processing time. To achieve these aims, a high directional Vivaldi …
Optical rogue-wave-like extreme value fluctuations in fiber Raman amplifiers
2008
International audience; We report experimental observation and characterization of rogue wave-like extreme value statistics arising from pump-signal noise transfer in a fiber Raman amplifier. Specifically, by exploiting Raman amplification with an incoherent pump, the amplified signal is shown to develop a series of temporal intensity spikes whose peak power follows a power-law probability distribution. The results are interpreted using a numerical model of the Raman gain process using coupled nonlinear Schrödinger equations, and the numerical model predicts results in good agreement with experiment.
School Bullying Through Graphic Vignettes : Developing a New Arts-Based Method to Study a Sensitive Topic
2020
The purpose of this study was to develop a new arts-based measure assessing school bullying and to test it within a pilot study involving 19 schoolchildren (mean age = 15.4; range = 1.00). The researchers designed the new methodological tool (referred to as graphic vignettes) as a set of incomplete comic strips, which participants were asked to complete in a creative way. Researchers then invited participants to engage in follow-up interviews using completed comic strips as individualized interview prompts. The authors detail the design and administration of the graphic vignettes and discuss their efficacy, limitations, and potential applications. The researchers argue that studies on sensi…