Search results for "Aira"
showing 10 items of 387 documents
Asumisen yhteisöllisyys ja hyvä vanhuus
2017
Veden merkitys mielisairaaloiden muuttuvissa hoitokulttuureissa
2019
STAT5b is a key effector of NRG-1/ERBB4-mediated myocardial growth
2023
The growth factor Neuregulin-1 (NRG-1) regulates myocardial growth and is currently under clinical investigation as a treatment for heart failure. Here, we demonstrate in several in vitro and in vivo models that STAT5b mediates NRG-1/EBBB4-stimulated cardiomyocyte growth. Genetic and chemical disruption of the NRG-1/ERBB4 pathway reduces STAT5b activation and transcription of STAT5b target genes Igf1, Myc, and Cdkn1a in murine cardiomyocytes. Loss of Stat5b also ablates NRG-1-induced cardiomyocyte hypertrophy. Dynamin-2 is shown to control the cell surface localization of ERBB4 and chemical inhibition of Dynamin-2 downregulates STAT5b activation and cardiomyocyte hypertrophy. In zebrafish e…
Organisational and individual resources as antecedents of older nursing professionals’ organisational commitment : Investigating the mediating effect…
2021
Aim and objectives To investigate how organisational and individual resources are linked to older (50+) nursing professionals’ organisational commitment, and to examine the possible mediating role of the active use of selection, optimisation and compensation (SOC) strategies. Background Many healthcare organisations need to find ways to retain their older nursing professionals due to nursing shortage. Design To test a set of hypotheses, cross-sectional survey data (n = 396) were used. Data were analysed using correlation analysis and partial least-squares structural equation modelling. STROBE Statement for cross-sectional studies has been followed in this study. Results The results exhibite…
Askarrutuksesta osaamiskeskukseksi : sairaalaopetuksen muutoskehityksen tarkastelu kehittävän työntutkimuksen viitekehyksessä
2018
Tämä tutkimus kohdistui suomalaisen sairaalaopetuksen järjestämisperusteiden ja käytänteiden ja menettelytapojen muutoskehitykseen. Päätutkimusongelmia oli neljä: 1. Millaisia vaiheita sairaalaopetuksessa on havaittavissa sen historiallisen kehityksen aikana? 2. Millaisia ovat sairaalaopetuksen tehtävä, toiminta ja käytänteet? 3. Miten työtoimintojen kehittäminen eteni kehittämishankkeiden aikana? ja 4. Millaiset toiminnalliset edellytykset sairaalaopetuksella arvioidaan olevan osaamiskeskuksena toimimiseen? Tutkimukseni metodologia perustui kehittävään työntutkimukseen. Sairaalaopetuksen järjestämisperusteiden kehityshistoriallista ja nykytilanteen analyysia käytettiin sairaalaopetuksen ty…
Structure of self-rated health among the oldest old: Analyses in the total population and those living with dementia
2020
No previous study has explored the structure of self-rated health (SRH), a measure holding strong predictive value for future health events, in the oldest old or in individuals with dementia. The aim was to construct a structural equation model of SRH for oldest old in general and for oldest old with dementia, and to explore direct and indirect associations between health-related factors and SRH. Cross-sectional data from the Vitality 90+, a population-based study in the city of Tampere, Finland, was used. Data were gathered by a mailed questionnaire in 2014. Altogether 1299 nonagenarians, of which 408 had self-reported dementia or cognitive decline, were included. Structural equation model…
(Ré)concilier éclairage urbain et environnement nocturne : les enjeux d’une controverse sociotechnique
2014
International audience; Our paper explains the birth of an environmental problem, i.e. light pollution, viewed as a socio-technical controversy. Supported by the actor-network approach, it traces over forty years the conditions of its emergence, transformation and dissemination to local, national and transnational levels and through various professional disciplines. Schematically, “environmentalists” uphold a holistic approach of “nocturnality” and define artificial light as a pollutant. Facing them, the “technicist” defends a segmented approach and defines artificial light as a nuisance. The introduction of this controversy into the political agenda leads to institutional decisions that gr…
One-Dimensional Convolutional Neural Networks Combined with Channel Selection Strategy for Seizure Prediction Using Long-Term Intracranial EEG
2022
Seizure prediction using intracranial electroencephalogram (iEEG) has attracted an increasing attention during recent years. iEEG signals are commonly recorded in the form of multiple channels. Many previous studies generally used the iEEG signals of all channels to predict seizures, ignoring the consideration of channel selection. In this study, a method of one-dimensional convolutional neural networks (1D-CNN) combined with channel selection strategy was proposed for seizure prediction. First, we used 30-s sliding windows to segment the raw iEEG signals. Then, the 30-s iEEG segments, which were in three channel forms (single channel, channels only from seizure onset or free zone and all c…
Nurse-led counseling for coronary artery disease patients : A 1-year follow-up study
2021
Nurse‐led counseling and systematic follow‐up has been shown to reduce cardiovascular risk factor levels. The study aim was to investigate if cardiovascular risk factor levels could be reduced in patients with coronary artery disease with a nurse‐led intervention and to report patients’ evaluations of nurse‐led counseling. The study design was a real‐life longitudinal follow‐up counseling intervention. Data were collected from November 2017 to May 2020. The nurse‐led intervention and patients’ follow‐up time was one year. Of the 78 patients recruited, 74 completed the study. The most significant findings were in the levels of total cholesterol, low‐density lipoprotein cholesterol and trigly…
Students’ school‐level symptoms mediate the relationship between a school’s observed moisture problems and students’ subjective perceptions of indoor…
2021
Moisture damage can influence the subjective assessment of indoor air quality (subjective IAQ) in various ways. We studied whether the frequency of symptoms reported across students at school level mediates the relationship between observed mold and dampness in a school building and students’ subjective IAQ. To answer this research question, we tested a multilevel path model. The analyzed data was created by merging two nationwide data sets: 1) survey data from students, including information on subjective IAQ (N = 24,786 students); 2) data from schools, including information on mold and dampness in a school building (N = 222). After the background variables were adjusted, schools’ observed…