Search results for "Ajuga"

Ajuga ivaaqueous extract improves reverse cholesterol transport in streptozotocin-induced diabetic rat

2012

AbstractObjectivesThe aim of this study was to determine the effects of Ajuga iva aqueous extract on lecithin : cholesterol acyltransferase (LCAT) activity and amount and composition of high-density lipoprotein (HDL)2 and (HDL)3, in streptozotocin (STZ)-induced diabetic rats.MethodsDiabetes was induced in male Wistar rats by intraperitoneal injection of STZ (60 mg/kg body weight). Diabetic rats (n = 12) were divided into two groups. The diabetic control group (D) received a 20% casein diet and the diabetic treated group received the same diet supplemented with A. iva aqueous extract (0.5 g/100 g diet) (DAi), for 4 weeks.Key findingsTotal cholesterol and HDL3-C were respectively decreased by…

Iridoid extracts from Ajuga iva increase the antioxidant enzyme activities in red blood cells of rats fed a cholesterol-rich diet.

2010

The lyophilized aqueous extract of Ajuga iva (Ai) is able to reduce oxidative stress, which may prevent lipid peroxidation in hypercholesterolemic rats. Iridoids (I) were isolated from Ai. We hypothesized that the antioxidant defense status in red blood cells (RBC) and tissues in rats fed a cholesterol-rich diet and treated with Ai may be correlated to these compounds. Male Wistar rats (n = 32) weighing 120 +/- 5 g were fed a diet containing 1% cholesterol for 15 days. After this phase, hypercholesterolemic (HC) rats were divided into groups, fed the same diet, and received either the same or different doses (5, 10, or 15 mg/kg body weight by intraperitoneal injection) of I for 15 days. Com…

Effect of an aqueous extract of Ajuga iva on glycaemia, reverse cholesterol transport and atherogenic ratios in rats with streptozotocin-induced diab…

2008

Effect of aqueous extract of Ajuga iva supplementation on plasma lipid profile and tissue antioxidant status in rats fed a high-cholesterol diet

2006

Abstract The present study was designed to explore the possible antioxidant and hypolipidemic effects of the aqueous extract of Ajuga iva (0.5% in the diet) in rats fed a high-cholesterol (1%) diet (HCD). The results indicated that the HCD-Ai versus HCD treatment led to many changes in biochemical parameters. They showed a decrease of plasma total cholesterol (TC) and VLDL-cholesterol but an increase of HDL2-cholesterol. The triacylglycerol contents were reduced in plasma and in VLDL. The lipid peroxidation determined by TBARS was decreased by 75% in plasma. TBARS in liver, heart and kidneys were highly reduced excepted in the adipose tissue. Ajuga iva treatment enhanced superoxide dismutas…

Changes in antioxidant defense status in hypercholesterolemic rats treated with Ajuga iva.

2007

Abstract The aim of the study was to investigate the effect of aqueous extract of Ajuga iva ( Ai ) on serum and tissues lipid peroxidation as well as antioxidant enzymes activities in red blood cells (RBC) and tissues, in high hypercholesterolemic rats (HC). Male Wistar rats ( n =12) were fed on 1% cholesterol-enriched diet for 15 d. After this adaptation phase, hypercholesterolemic rats (total cholesterol=6.5±0.6 mol/l) were divided into two groups fed the same diet and treated or not with Ai for 15 d. Thiobarbituric acid reactive substances (TBARS) concentrations in serum, LDL-HDL 1 , HDL 2 and HDL 3 were respectively, 5-, 7.8-, 2.3- and 5-fold lower in Ai treated than untreated hyperchol…

Metabolites from Mediterranean plants: characterization and transformation. Chemotaxonomic assessment and biological activity.

Questo progetto di ricerca ha lo scopo di ampliare le conoscenze di alcune piante appartenenti alla flora Mediterranea. Le piante da studiare sono state scelte in seguito ad un’attenta analisi bibliografica tra specie poco sudiate. La scelta è quindi ricaduta su nove specie appartenenti al genere Anthemis, due specie appartenenti al genere Pulicaria e sulle specie di Tetraclinis articulata, Salvia argentea, Ajuga tenorei, Ballota hispanica, Moluccella Spinosa e Thapsia garganica. Di esse sono stati preparati ed identificati i componenti degli oli essenziali e successivamente effettuati su di essi i saggi antibatterici. Dagli estratti delle specie di Tetraclinis articulata e Ajuga tenorei so…

Metabolites from Mediterranean plant: characterization and trasformation. chemotaxonomic assessmentand biological activity

2016

Questo progetto di ricerca ha lo scopo di ampliare le conoscenze di alcune piante appartenenti alla flora Mediterranea. Le piante da studiare sono state scelte in seguito ad un’attenta analisi bibliografica tra specie poco sudiate. La scelta è quindi ricaduta su nove specie appartenenti al genere Anthemis, due specie appartenenti al genere Pulicaria e sulle specie di Tetraclinis articulata, Salvia argentea, Ajuga tenorei, Ballota hispanica, Moluccella Spinosa e Thapsia garganica. Di esse sono stati preparati ed identificati i componenti degli oli essenziali e successivamente effettuati su di essi i saggi antibatterici. Dagli estratti delle specie di Tetraclinis articulata e Ajuga tenorei so…

Scuteparvin, a new neoclerodane diterpenoid from Scutellaria parvula

2004

Abstract The diterpenoid fraction occurring in the acetone extract of the aerial parts of Scutellaria parvula has been investigated. Only one neoclerodane diterpenoid, scuteparvin, was isolated and its structure elucidated as 4α,18-epoxy-6α- trans -cinnamoyloxy- neo clerod-13-en-15,16-olide, a new natural product. Scuteparvin is quite similar to the already known ajugarin V from Ajuga remota , the only difference being the occurrence of a trans -cinnamoyl ester system instead of an acetate on the 6α-OH group. This finding confirms that the genera Scutellaria and Ajuga are closely related taxonomically.