Search results for "Aka"

EULAR/PRINTO/PRES criteria for Henoch-Schonlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arte…

2010

EULAR/PRINTO/PRES Objectives To validate the previously proposed classification criteria for Henoch-Schonlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA).Methods Step 1: retrospective/prospective webdata collection for children with HSP, c-PAN, c-WG and c-TA with age at diagnosis <= 18 years. Step 2: blinded classification by consensus panel of a representative sample of 280 cases. Step 3: statistical (sensitivity, specificity, area under the curve and.-agreement) and nominal group technique consensus evaluations.Results 827 patients with HSP, 150 with c-PAN, 60 with c-WG, 87 with c-TA and 52 with c-other were compar…

Spontaneous Endoreduplication, Tetraploidy and Chromosome Breakage in Lymphocyte Cultures from Healthy Subjects

1984

SUMMARY42,703 metaphases of peripheral lymphocytes from 20 healthy subjects (10 women and 10 men) were examined in order to establish the frequency of endoreduplicated cells and of tetraploid cells without diplochromosomes. Frequencies were found to be 0.016% and 0.112%, respectively. The two sexes did not differ as to the frequency of tetraploid cells, with and without diplochromosomes (about 0.13% in either sex). In a total of 2,135 well spread metaphases examined, 26 cells (i.e. 1.2%) with chromosomal breaks were found. Again, no significant differences between the two sexes were found as to such chromosome abnormalities.

Plasticity of human chromosome 3 during primate evolution.

2004

Comparative mapping of more than 100 region-specific clones from human chromosome 3 in Bornean and Sumatran orangutans, siamang gibbon, and Old and New World monkeys allowed us to reconstruct ancestral simian and hominoid chromosomes. A single paracentric inversion derives chromosome 1 of the Old World monkey Presbytis cristata from the simian ancestor. In the New World monkey Callithrix geoffroyi and siamang, the ancestor diverged on multiple chromosomes, through utilizing different breakpoints. One shared and two independent inversions derive Bornean orangutan 2 and human 3, implying that neither Bornean orangutans nor humans have conserved the ancestral chromosome form. The inversions, f…

De novo t(12;17)(p13.3;q21.3) translocation with a breakpoint near the 5' end of the HOXB gene cluster in a patient with developmental delay and skel…

2007

A boy with severe mental retardation, funnel chest, bell-shaped thorax, and hexadactyly of both feet was found to have a balanced de novo t(12;17)(p13.3;q21.3) translocation. FISH with BAC clones and long-range PCR products assessed in the human genome sequence localized the breakpoint on chromosome 17q21.3 to a 21-kb segment that lies <30 kb upstream of the HOXB gene cluster and immediately adjacent to the 3′ end of the TTLL6 gene. The breakpoint on chromosome 12 occurred within telomeric hexamer repeats and, therefore, is not likely to affect gene function directly. We propose that juxtaposition of the HOXB cluster to a repetitive DNA domain and/or separation from required cis-regulatory …

Genomic structure and paralogous regions of the inversion breakpoint occurring between human chromosome 3p12.3 and orangutan chromosome 2.

2003

Intrachromosomal duplications play a significant role in human genome pathology and evolution. To better understand the molecular basis of evolutionary chromosome rearrangements, we performed molecular cytogenetic and sequence analyses of the breakpoint region that distinguishes human chromosome 3p12.3 and orangutan chromosome 2. FISH with region-specific BAC clones demonstrated that the breakpoint-flanking sequences are duplicated intrachromosomally on orangutan 2 and human 3q21 as well as at many pericentromeric and subtelomeric sites throughout the genomes. Breakage and rearrangement of the human 3p12.3-homologous region in the orangutan lineage were associated with a partial loss of dup…

Роль Академической библиотеки Латвийского Университета в развитии научных и культурных взаимоотношений Латвии и Грузии

2015

Tipogrāfs Gerhards Šrēders un latīņu okazionālā dzeja

2019

Rakstā atainota Rīgas pilsētas otrā tipogrāfa Gerharda Šrēdera (Gerhard Schröder, ?-1657) darbības vide un dzīvesgājums. Vispirms iezīmēti grāmatiespiešanas pirmsākumi Rīgā, tipogrāfa pienākumi, pasūtījumu klāsts, atlīdzība par darbu un iegūstamās privilēģijas. Tad aplūkoti priekšnoteikumi, kas Gerhardam Šrēderam bija jāizpilda, lai iegūtu Rātes atļauju pārņemt darbu Nikolaja Mollīna (Niclaes Mollijns, ap 1550/1555-1625) spiestuvē. Tipogrāfijas kvalitātes un iespieddarbu specifikas raksturošanai pētīti okazionālās dzejas iespieddarbi: apskatīts poligrāfiskais izpildījums (vienā iespieddarbā izmantoto dažādo izmēru un veidu burtu komplektu skaits, dekoratīvo elementu, kokgrebumu un gravīru p…

Visioni da Oscar. Giuseppe La Spada

2010

Giuseppe La Spada, giovane pluripremiato designer di origini siciliane, ma ormai divenuto viaggiatore e cittadino del mondo, con il suo lavoro dimostra quanto sia difficile oggi parlare di aree disciplinari nel campo del design, intese come compartimenti stagni, così come eravamo abituati a fare non più di qualche decennio addietro, quando strutturare una mappa del design consentiva di organizzare un quadro sinottico, chiaro e discretizzato, in cui trovavano posto tra gli altri aree, nomi, progetti, correnti, periodi storici. Giuseppe La Spada, the young, multi-prize winning designer of Sicilian origin, is now a traveller and citizen of the world. His work shows just how difficult it is tod…

Entrepreneurial choices depend on trust : Some global evidence

2022

Interpersonal trust and people’s trust in institutions are important components of social capital, which has been shown to have not only innate social value but also diverse direct and indirect positive social and economic impacts. Using data for an economically and globally diverse group of countries, we examine empirically how changes in interpersonal trust and trust in institutions affect entrepreneurship over time. Our findings suggest that (1) enhancing either type of trust leads to more entrepreneurial activity and (2) an increase in interpersonal trust causes a structural change in the composition of the TEA-type entrepreneurship. Increased trust reduces the share of relatively lower…

Spatial autocorrelation and the selection of simultaneous autoregressive models

2007

Aim Spatial autocorrelation is a frequent phenomenon in ecological data and can affect estimates of model coefficients and inference from statistical models. Here, we test the performance of three different simultaneous autoregressive (SAR) model types (spatial error = SAR err , lagged = SAR lag and mixed = SAR mix ) and common ordinary least squares (OLS) regression when accounting for spatial autocorrelation in species distribution data using four artificial data sets with known (but different) spatial autocorrelation structures. Methods We evaluate the performance of SAR models by examining spatial patterns in model residuals (with correlograms and residual maps), by comparing model para…