Search results for "Alaria"
showing 10 items of 273 documents
Non-stochastic quadratic fingerprints and LDA-based QSAR models in hit and lead generation through virtual screening: theoretical and experimental as…
2005
In order to explore the ability of non-stochastic quadratic indices to encode chemical information in antimalarials, four quantitative models for the discrimination of compounds having this property were generated and statistically compared. Accuracies of 90.2% and 83.3% for the training and test sets, respectively, were observed for the best of all the models, which included non-stochastic quadratic fingerprints weighted with Pauling electronegativities. With a comparative purpose and as a second validation experiment, an exercise of virtual screening of 65 already-reported antimalarials was carried out. Finally, 17 new compounds were classified as either active/inactive ones and experimen…
Application of molecular topology to the prediction of the antimalarial activity of a group of uracil-based acyclic and deoxyuridine compounds.
2008
A topological-mathematical model has been arranged to search for new derivatives of deoxyuridine and related compounds acting as antimalarials against Plasmodium falciparum. By using linear discriminant and multilinear regression analysis a model with two functions was capable to predict adequately the IC(50) for each compound of the training and test series. After carrying out a virtual screening based upon such a model, new structures potentially active against P. falciparum are proposed.
Pentamethylcyclopentadienyl-rhodium and iridium complexes containing (N^N and N^O) bound chloroquine analogue ligands: synthesis, characterization an…
2016
The synthesis and characterization of twenty new pentamethylcyclopentadienyl-rhodium and iridium complexes containing N^N and N^O-chelating chloroquine analogue ligands are described. The in vitro antimalarial activity of the new ligands as well as the complexes was evaluated against the chloroquine sensitive (CQS) NF54 and the chloroquine resistant (CQR) Dd2 strains of Plasmodium falciparum. The antimalarial activity was found to be good to moderate; although all complexes are less active than artesunate, some of the ligands and complexes showed better activity than chloroquine (CQ). In particular, rhodium complexes were found to be considerably more active than iridium complexes against t…
New Biologically Active Triterpene-Saponins fromRandia dumetorum
1990
Two new triterpene-saponins, 3-O-[O-beta-D-glucopyranosyl-(1----4)-O-beta-D-glucopyranosyl-(1----3)-( beta- D-glucuronopyranosyl)]oleanolic acid (1), 3-O-[O-beta-D-glucopyranosyl-(1----6)-O-beta-D-glucopyranosyl- (1----3)-(beta-D-glucuronopyranosyl)]oleanolic acid (2) together with five known saponins (3-7) were isolated from the methanolic extract of the fruits of Randia dumetorum (Retz) Lam. (Rubiaceae). Their structures were established on the basis of chemical and spectral data. The compounds 1, 3, 4, 5 were found to enhance significantly the proliferation of human lymphocytes in vitro. The crude saponin fraction showed haemolytic, molluscicidal, and immunostimulating activities.
The overlapping burden of the three leading causes of disability and death in sub-Saharan African children
2022
Publisher Copyright: © 2022, The Author(s). Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseas…
La mundialización de un fútbol para ricos / 2
2006
Social Vision on Wet Nurses in the [Spanish] Newspaper “La Vanguardia” (1881-1908)
2017
Históricamente ha habido situaciones y momentos en que las madres han delegado el proceso de lactancia en nodrizas. En el siglo XIX las nodrizas fueron representadas en la prensa española reproduciendo los esquemas del modelo social androcéntrico imperante. Se pretende describir y categorizar la visión de la nodriza reflejada en la prensa española mediante el análisis de contenido de las fuentes periodísticas de este período. La conclusión alcanzada han sido que la prensa refleja la importancia social de la nodriza como un elemento normalizado en la sociedad con un papel fundamental en los aspectos demográficos de la sociedad, estableciendo una visión dual en función del grupo social al que…
A New Benzopyranyl Cadenane Sesquiterpene and Other Antiplasmodial and Cytotoxic Metabolites from Cleistochlamys kirkii
2019
Phytochemical investigations of ethanol root bark and stem bark extracts of Cleistochlamys kirkii (Benth.) Oliv. (Annonaceae) yielded a new benzopyranyl cadinane-type sesquiterpene (cleistonol, 1) alongside 12 known compounds (2&ndash
Cembali from beyond the lighthouse. Harpsichord makers in Sicily
2009
La rentabilité salariale des parcours d'études non linéaires
2016
International audience; En France, les reprises d'études sont de moins en moins rares. La question de la poursuite d'études comme alternative à l'entrée sur le marché du travail se pose puisqu'elle représente un coût pour les individus. Si certaines études ont tenté d'évaluer l'impact du retour en formation longue sur la situation professionnelle, il serait intéressant de s'interroger sur sa rentabilité en termes de revenus. Nous mettons en évidence la difficulté de mesurer l'écart de salaires entre les parcours linéaires et les reprises d'études. Au premier abord, la reprise d'études semble avoir un impact positif sur les salaires. Cependant, en comparant la valeur des niveaux de diplôme d…