6533b7d7fe1ef96bd12684a7
RESEARCH PRODUCT
New Biologically Active Triterpene-Saponins fromRandia dumetorum
Marie-aleth DuboisSabine BenzeHildebert Wagnersubject
MolluscacidesStereochemistryRandiaSaponinPharmaceutical SciencePharmacognosyLymphocyte ActivationAnalytical Chemistrychemistry.chemical_compoundTriterpeneDrug DiscoveryAnimalsLymphocytesMedicinal plantsOleanolic acidPharmacologychemistry.chemical_classificationPlants MedicinalRubiaceaeBiomphalariabiologyOrganic ChemistrySaponinsbiology.organism_classificationTriterpenesTerpenoidcarbohydrates (lipids)Complementary and alternative medicinechemistryMolecular Medicinedescription
Two new triterpene-saponins, 3-O-[O-beta-D-glucopyranosyl-(1----4)-O-beta-D-glucopyranosyl-(1----3)-( beta- D-glucuronopyranosyl)]oleanolic acid (1), 3-O-[O-beta-D-glucopyranosyl-(1----6)-O-beta-D-glucopyranosyl- (1----3)-(beta-D-glucuronopyranosyl)]oleanolic acid (2) together with five known saponins (3-7) were isolated from the methanolic extract of the fruits of Randia dumetorum (Retz) Lam. (Rubiaceae). Their structures were established on the basis of chemical and spectral data. The compounds 1, 3, 4, 5 were found to enhance significantly the proliferation of human lymphocytes in vitro. The crude saponin fraction showed haemolytic, molluscicidal, and immunostimulating activities.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1990-10-01 | Planta Medica |