Search results for "Alcohol"
showing 10 items of 1798 documents
Darstellung einer homologen Reihe von oligoallylalkoholen mit 1-cyano-1-methylethyl-endgruppen. Beispiel einer mehrfachen matrizenreaktion und einer …
1984
Reduction and hydrolysis of the ladder oligomers 1, 2, 3, 4, and 5 prepared from the acrylates of oligo (hydroxyphenylene-methylene)s was found to lead to a homologous series of oligo (allylalcohol)s (6a, 7a, 8a, 9a and10a) with good yields. These alcohols were characterized by analytical and spectroscopic methods. The reaction sequences, starting with the esterification of the oligo[(hydroxyphenylene) methylene]s 11a – 11e with acryloyl chloride followed by the formation of the ladder oligomers and ending with their reduction and hydrolysis into the oligo(allyl alcohol)s and the starting compounds 11a – 11e, represent a simple matrix reaction. A mixture of multiple acrylates was also subje…
Stereoselective Hydrosilylation of Enals and Enones Catalysed by Palladium Nanoparticles
2011
A highly versatile and efficient hydrosilylation method by palladium nanoparticle catalysis allows the direct and chemoselective synthesis of 1) enolsilanes of high isomeric purity, 2) saturated aldehydes or ketones, or 3) the corresponding saturated acetals from α,β-unsaturated aldehydes or ketones. The choice of the product is determined by simply switching the solvent from THF to mixtures of THF/water or THF/alcohol.
Enzymes for the NADPH-dependent reduction of dihydroxyacetone and D-glyceraldehyde and L-glyceraldehyde in the mould Hypocrea jecorina
2006
The mould Hypocrea jecorina (Trichoderma reesei) has two genes coding for enzymes with high similarity to the NADP-dependent glycerol dehydrogenase. These genes, called gld1 and gld2, were cloned and expressed in a heterologous host. The encoded proteins were purified and their kinetic properties characterized. GLD1 catalyses the conversion of d-glyceraldehyde and l-glyceraldehyde to glycerol, whereas GLD2 catalyses the conversion of dihydroxyacetone to glycerol. Both enzymes are specific for NADPH as a cofactor. The properties of GLD2 are similar to those of the previously described NADP-dependent glycerol-2- dehydrogenases (EC 1.1.1.156) purified from different mould species. It is a reve…
Applications of the Alcohol Use Disorders Identification Test (AUDIT) in Distinct Health Areas
2019
Abstract This chapter provides an updated vision of the contexts in which the psychometric viability of the AUDIT has been evaluated during this century. This has permitted the identification of why, where, and how this screening method, as well as its most well-known abridged version (the AUDIT-C), is being used in different socio-sanitary areas. Throughout the chapter, appropriate recommendations are offered for all professionals wishing to use these instruments, while also pointing out potential future research lines.
¿Se benefician de los programas de intervención que no tratan específicamente el consumo de alcohol los maltratadores con problemas de consumo abusiv…
2013
En el ámbito de la intervención con maltratadores y de la investigación en torno a la mejora de la efectividad de estas intervenciones el consumo abusivo de alcohol ha sido uno de los factores de riesgo que ha recibido especial atención. El objetivo de este trabajo es analizar la relación entre el consumo abusivo de alcohol, el proceso de cambio debido a la intervención y el abandono prematuro. Para ello se utilizó una muestra de 86 hombres consumidores de riesgo y 80 hombres no consumidores de riesgo, todos ellos condenados por violencia contra la mujer en las relaciones de pareja y participando en un programa de intervención en medio comunitario que no trata específicamente el problema de…
¿Se benefician de los programas de intervención que no tratan específicamente el consumo de alcohol los maltratadores con problemas de consumo abusiv…
2013
ResumenEn el ámbito de la intervención con maltratadores y de la investigación en torno a la mejora de la efectividad de estas intervenciones el consumo abusivo de alcohol ha sido uno de los factores de riesgo que ha recibido especial atención. El objetivo de este trabajo es analizar la relación entre el consumo abusivo de alcohol, el proceso de cambio debido a la intervención y el abandono prematuro. Para ello se utilizó una muestra de 86 hombres consumidores de riesgo y 80 hombres no consumidores de riesgo, todos ellos condenados por violencia contra la mujer en las relaciones de pareja y participando en un programa de intervención en medio comunitario que no trata específicamente el prob…
Metabolic Consequences of Obstructive Sleep Apnea
2022
The effects of OSA on metabolism are quite complex, and obesity, diabetes, nonalcoholic fatty liver disease and dyslipidemia often coexist with OSA, making it difficult to tease out the independent effects of OSA on metabolic variables. There is firm experimental evidence of a detrimental impact of OSA on adipose tissue dysfunction, with intermittent hypoxia, sympathetic hyperactivity, and oxidative stress as the most important intermediate mechanisms. Sleep fragmentation or deprivation may also contribute to the metabolic dysfunction of OSA. This work reviews the current knowledge on this topic, as well as the results of studies on the effects of CPAP treatment.
Association of Dietary Patterns with MRI Markers of Hepatic Inflammation and Fibrosis in the MAST4HEALTH Study
2022
Whereas the etiology of non-alcoholic fatty liver disease (NAFLD) is complex, the role of nutrition as a causing and preventive factor is not fully explored. The aim of this study is to associate dietary patterns with magnetic resonance imaging (MRI) parameters in a European population (Greece, Italy, and Serbia) affected by NAFLD. For the first time, iron-corrected T1 (cT1), proton density fat fraction (PDFF), and the liver inflammation fibrosis score (LIF) were examined in relation to diet. A total of 97 obese patients with NAFLD from the MAST4HEALTH study were included in the analysis. A validated semi-quantitative food frequency questionnaire (FFQ) was used to assess the quality of diet…
Rare ATG7 genetic variants predispose patients to severe fatty liver disease
2022
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver disorders and has a strong heritable component. The aim of this study was to identify new loci that contribute to severe NAFLD by examining rare variants.Methods: We performed whole-exome sequencing in in-dividuals with NAFLD and advanced fibrosis or hepatocellular carcinoma (n = 301) and examined the enrichment of likely pathogenic rare variants vs. the general population. This was followed by validation at the gene level.Results: In patients with severe NAFLD, we observed an enrichment of the p.P426L variant (rs143545741 C>T; odds ratio [OR] 5.26, 95% CI 2.1-12.6; p = 0.003) of autophagy-rela…
Posibles actuaciones psicológicas para reducir la conducción bajo los efectos del alcohol y viabilidad de su aplicación en España
2004
María Teresa Cortés Tomás. Departamento de Psicología Básica. Facultad de Psicología. UV E-mail: Maria.T.Cortes@uv.es. Las recientes modificaciones en la legislación sobre Tráfico y Seguridad Vial (Ley 19/2001) reflejan la necesidad de clarificar los posibles procedimientos a realizar con los conductores sancionados por conducir bajo la influencia del alcohol. Tras verificar la reducida efectividad de las medidas aplicadas en España y revisar las actuaciones realizadas en otros países, destacamos los programas educativos y terapéuticos por ser las intervenciones más estructuradas y con resultados más favorables. En este trabajo, presentamos una descripción de estos programas así como una se…