Search results for "Algorithm"

Integration of local features into a global shape

2001

AbstractIt is a well-established fact that the cortical filters selective for spatial frequency and orientation have a limited spatial extent. The present study investigated how information from local filters is integrated into global shapes. Specifically, we were interested in whether identification of a global pattern consisting of small oriented, spatially-bandpass features (Gabor patches) depends on the orientations of those features. The observer was presented with a C-like stimulus shape comprised of oriented Gabor elements on a blank background, and the performance measure was the threshold contrast for identifying the global orientation of the C-shape (four possible rotated orientat…

Improved Magic Ink Signatures Using Hints

1999

We introduce two improvements to the recently proposed so called magic ink DSS signatures. A first improvement is that we reduce the overhead for tracing without noticeably increasing any other cost. The tracing cost is linear in the number of generated signatures in the original proposal; our improved version reduces this to a logarithmic cost in the common case. A second improvement is that we introduce a method for determining whether forged currency is in circulation, without affecting the privacy of honest users. Our improvements rely on our introducing a so called hint value. This is an encryption of the signature transcript received, submitted by the signature receiver. Part of the p…

Authors' Response.

2019

Prediction of bleeding events in patients with venous thromboembolism on stable anticoagulation treatment.

2016

Attempts at identifying patients with an elevated risk of bleeding while on anticoagulation following acute venous thromboembolism (VTE) have largely been unsuccessful thus far. We sought to develop a clinical prediction score for bleeding during stable anticoagulation treatment after acute VTE.We performed a post hoc analysis of the pooled RE-COVER studies, two double-blind randomised “sister” trials evaluating dabigatran versus standard treatment in 5107 VTE patients.A score was derived from patients randomised to dabigatran using logistic regression analysis covering the complete follow-up period. The final model, named VTE-BLEED, included six variables and yielded a c-statistic of 0.72 …

Predicting Responders to Reslizumab after 16 Weeks of Treatment Using an Algorithm Derived from Clinical Studies of Patients with Severe Eosinophilic…

2018

Reslizumab is a humanized anti-IL-5 monoclonal antibody used as add-on maintenance treatment for patients with uncontrolled eosinophilic asthma.To predict response and nonresponse to intravenous reslizumab at 52 weeks with an algorithm we developed based on clinical indicators from pivotal clinical trials.Patients aged 18 years and older who met Global Initiative for Asthma 4 or 5 criteria and received intravenous reslizumab (n = 321) in two trials ( www.clinicaltrials.gov identifiers, NCT01287039 and NCT01285323) were selected as the data source. A mathematical model was constructed that was based on change from baseline to 16 weeks in Asthma Control Questionnaire and Asthma Quality of Lif…

Hereditary angiodema: a current state-of-the-art review, VII: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, a…

2008

Background We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) in 2004. Objective To ensure that this consensus remains current. Methods In collaboration with the Canadian Network of Rare Blood Disorder Organizations, we held the second Canadian Consensus discussion with our international colleagues in Toronto, Ontario, on February 3, 2006, and reviewed its content at the Fifth C1 Inhibitor Deficiency Workshop in Budapest on June 2, 2007. Papers were presented by international investigators, and this consensus algorithm approach resulted. Results This consensus algorithm …

Design and Simulation of Measurement-Based Correlation Models for Shadow Fading

2011

This paper deals with the design of measurement-based correlation models for shadow fading. Based on the correlation model, we design a simulation model using the sum-of-sinusoids (SOS) method to enable the simulation of spatial lognormal processes characterizing real-world shadow fading scenarios. The model parameters of the simulation model are computed by applying the Lp-norm method (LPNM). This method facilitates an excellent fitting of the simulation model’s autocorrelation function (ACF) to that of measured channels. Our study includes an evaluation of all important statistical quantities of the proposed measurement-based simulation model, such as the probability density function (PDF…

An Improved Iterative Nonlinear Least Square Approximation Method for the Design of SISO Wideband Mobile Radio Channel Simulators

2012

In this paper, we present an improved version of the iterative nonlinear least square approximation (INLSA) method for designing measurement-based single-input single-output (SISO) wideband channel simulators. The proposed method aims to fit the time-frequency correlation function (TFCF) of the simulation model to that of a measured channel. The parameters of the simulation model are determined iteratively by minimizing the Frobenius norm, which serves as a measure for the fitting error. In contrast to the original INLSA method, the proposed approach provides a unique optimized set of model parameters, which guarantees a quasi-perfect fitting with respect to the TFCF. We analyze the perform…

Prognostic impact of copeptin in pulmonary embolism: a multicentre validation study.

2018

To externally validate the prognostic impact of copeptin, either alone or integrated in risk stratification models, in pulmonary embolism (PE), we performed a post hoc analysis of 843 normotensive PE patients prospectively included in three European cohorts.Within the first 30 days, 21 patients (2.5%, 95% CI 1.5–3.8) had an adverse outcome and 12 (1.4%, 95% CI 0.7–2.5) died due to PE. Patients with copeptin ≥24 pmol·L−1 had a 6.3-fold increased risk for an adverse outcome (95% CI 2.6–15.5, p<0.001) and a 7.6-fold increased risk for PE-related death (95% CI 2.3–25.6, p=0.001). Risk classification according to the 2014 European Society of Cardiology (ESC) guideline algorithm identified 248…

ISHLT consensus document on lung transplantation in patients with connective tissue disease: Part I: Epidemiology, assessment of extrapulmonary condi…

2021

Patients with connective tissue disease (CTD) and advanced lung disease are often considered suboptimal candidates for lung transplantation (LTx) due to their underlying medical complexity and potential surgical risk. There is substantial variability across LTx centers regarding the evaluation and listing of these patients. The International Society for Heart and Lung Transplantation-supported consensus document on lung transplantation in patients with CTD standardization aims to clarify definitions of each disease state included under the term CTD, to describe the extrapulmonary manifestations of each disease requiring consideration before transplantation, and to outline the absolute contr…