Search results for "Algorithm"
showing 10 items of 4887 documents
The diagnostic performance of renal function-adjusted D-dimer testing in individuals suspected of having venous thromboembolism
2019
Renal impairment, a source of chronic hypercoagulability[1][1] and inflammation,[2][2] is known to reduce the specificity of the D-dimer test in the diagnosis of venous thromboembolism (VTE).[3][3] This leads to many false positives in such patients and consequently to additional costs, as well as
Influence of heart rate in the selection of the optimal reconstruction window in routine clinical multislice coronary angiography
2008
Purpose. The aim of our study was to assess the influence of heart rate on the selection of the optimal reconstruction window with 40-slice multidetector-row computed tomography (40-MDCT) coronary angiography. Materials and methods. We studied 170 patients (114 men, age 60 +/- 11.3 years) with suspected or known coronary artery disease with 40-MDCT coronary angiography. Patients [mean heart rate (HR) 62.9 +/- 9.3 bpm, range 42-94 bpm] were clustered in two groups (group A: HR <= 65 bpm; group B: HR >65 bpm). Multiphase reconstruction data sets were obtained with a retrospective electrocardiogram (ECG)-gated 40-MDCT coronary angiography scan from 0% to 95% every 5% of the R-R interval.…
Clinical characteristics and determinants of the phenotype in TMEM43 arrhythmogenic right ventricular cardiomyopathy type 5.
2020
Arrhythmogenic right ventricular cardiomyopathy type V (ARVC-5) is the most aggressive heterozygous form of ARVC. It is predominantly caused by a fully penetrant mutation (p.S358L) in the nondesmosomal gene TMEM43-endemic to Newfoundland, Canada. To date, all familial cases reported worldwide share a common ancestral haplotype. It is unknown whether the p.S358L mutation by itself causes ARVC-5 or whether the disease is influenced by genetic or environmental factors. The purpose of this study was to examine the phenotype, clinical course, and the impact of exercise on patients with p.S358L ARVC-5 without the Newfoundland genetic background. We studied 62 affected individuals and 73 noncarrie…
Selection of optimal prophylactic aminoglycoside dosage in cancer patients: population pharmacokinetic approaches.
1994
We report an alternative dose-finding approach for the selection of optimal prophylactic aminoglycoside dosage in specific (sub)populations of patients. Relative a priori utility of several intervals of gentamicin or tobramycin (AMG) peak and trough serum levels were assigned by a group of pharmacokinetics experts, assuming prophylactic administration for laryngectomy interventions. A group of 27 adult patients, with normal renal function, undergoing elective surgery for laryngeal problems and treated prophylactically with gentamicin (80 mg t.i.d.) or tobramycin (100 mg t.i.d.) was studied. Two blood samples (peak and trough) were drawn at steady-state for AMG assay. Three different methods…
Assessing body composition with DXA and bioimpedance: effects of obesity, physical activity, and age.
2008
Objective: This study evaluated to what extent dual-energy X-ray absorptiometry (DXA) and two types of bioimpedance analysis (BIA) yield similar results for body fat mass (FM) in men and women with different levels of obesity and physical activity (PA). Methods and Procedures: The study population consisted of 37–81-year-old Finnish people (82 men and 86 women). FM% was estimated using DXA (GE Lunar Prodigy) and two BIA devices (InBody (720) and Tanita BC 418 MA). Subjects were divided into normal, overweight, and obese groups on the basis of clinical cutoff points of BMI, and into low PA (LPA) and high PA (HPA) groups. Agreement between the devices was calculated by using the Bland–Altman …
Investigating cardiac and respiratory determinants of heart rate variability in an information-theoretic framework.
2014
This study was aimed at comparing two alternative information-theoretic approaches for the combined analysis of heart rate variability (HRV) and respiration variability (RV). The approaches decompose the predictive information about HRV in two terms, quantifying respectively the information stored into HRV and that transferred to HRV from RV. Storage and transfer were assessed by the popular self entropy (SE) and transfer entropy (TE) measures, as well as by the alternative conditional SE (cSE) and cross entropy (CE) measures. The comparison was performed at a theoretical level, computing the exact values of the four measures for simulated cardiorespiratory dynamics, and on real data, estim…
Effects of Lorazepam on the automatic online evaluation of sleep EEG data in healthy volunteers.
1998
In earlier publications we described an automatic algorithm to detect rapid eye movement (REM) sleep from a single-channel EEG recording without using EMG or EOG information. This system consisted of an artificial neural network operating on the basis of preprocessed EEG data and was composed to provide a maximum of robustness for online applications. In the present study the influence of acute administration of lorazepam on the performance of the REM detection procedure was evaluated. Following an adaptation to laboratory conditions, sleep EEG data were obtained from healthy subjects in three nights each. On the evening of the second night the volunteers received a single dosage of 2.5 mg …
Influence of Patient Selection on the Outcome of Capsule Endoscopy in Patients With Chronic Gastrointestinal Bleeding
2005
Background: In chronic gastrointestinal bleeding, success rates in the range of 48% to 76% have been reported for diagnosing clear bleeding sources using capsule endoscopy. The influence of patient selection on the numbers of positive findings yielded by capsule endoscopy is as yet unclear. Methods: From April 2001 to June 2003, capsule endoscopy was carried out in 74 of a total of 127 patients (58%) who presented for capsule endoscopy with a high suspicion of gastrointestinal bleeding in the small-bowel region. Seventy of the 74 patients were included in the analysis. This group of patients was divided into a study group (32 patients) and a post-study group (38 patients), and the two group…
Improvement and generalization of arm motor performance through motor imagery practice
2005
This study compares the improvement and generalization of arm motor performance after physical or mental training in a motor task requiring a speed-accuracy tradeoff. During the pre- and post-training sessions, 40 subjects pointed with their right arm as accurately and as fast as possible toward targets placed in the frontal plane. Arm movements were performed in two different workspaces called right and left paths. During the training sessions, which included only the right path, subjects were divided into four training groups (n = 10): (i) the physical group, subjects overtly performed the task; (ii) the mental group, subjects imagined themselves performing the task; (iii) the active cont…
Effect of High-Fidelity Simulation on Medical Students' Knowledge about Advanced Life Support: A Randomized Study
2015
High-fidelity simulation (HFS) is a learning method which has proven effective in medical education for technical and non-technical skills. However, its effectiveness for knowledge acquisition is less validated. We performed a randomized study with the primary aim of investigating whether HFS, in association with frontal lessons, would improve knowledge about advanced life support (ALS), in comparison to frontal lessons only among medical students. The secondary aims were to evaluate the effect of HFS on knowledge acquisition of different sections of ALS and personal knowledge perception. Participants answered a pre-test questionnaire consisting of a subjective (evaluating personal percepti…