Search results for "Allantoin"
showing 8 items of 8 documents
Plasma Metabolomics Profiles are Associated with the Amount and Source of Protein Intake: A Metabolomics Approach within the PREDIMED Study.
2020
SCOPE: The plasma metabolomics profiles of protein intake has been rarely investigated. We aimed to identify the distinct plasma metabolomics profiles associated with overall intakes of protein as well as with intakes from animal and plant protein sources. METHODS AND RESULTS: Cross-sectional analysis using data from 1,833 participants at high risk of cardiovascular disease. Plasma metabolomics analysis was performed using LC-MS. Associations between 385 identified metabolites and the intake of total, animal protein (AP) and plant protein (PP), and plant-to-animal ratio (PR) were assessed using elastic net continuous regression analyses. A double 10-cross-validation (CV) procedure was used …
Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism
2019
Studies examining associations between purine metabolites and type 2 diabetes (T2D) are limited. We prospectively examined associations between plasma levels of purine metabolites with T2D risk and the modifying effects of transcription factor-7-like-2 (TCF7L2) rs7903146 polymorphism on these associations. This is a case-cohort design study within the PREDIMED study, with 251 incident T2D cases and a random sample of 694 participants (641 non-cases and 53 overlapping cases) without T2D at baseline (median follow-up: 3.8 years). Metabolites were semi-quantitatively profiled with LC-MS/MS. Cox regression analysis revealed that high plasma allantoin levels, including allantoin-to-uric acid rat…
COMBINATION OF ARGAN OIL AND PHOSPHOLIPIDS FOR THE DEVELOPMENT OF AN EFFECTIVE LIPOSOME-LIKE FORMULATION ABLE TO IMPROVE SKIN HYDRATION AND ALLANTOIN…
2016
Allantoin is traditionally employed in the treatment of skin ulcers and hypertrophic scars. In the present work, to improve its local deposition in the skin and deeper tissues, allantoin was incorporated in conventional liposomes and in new argan oil enriched liposomes. In both cases, obtained vesicles were unilamellar, as confirmed by cryo-TEM observation, but the addition of argan oil allowed a slight increase of the mean diameter (∼130nm versus ∼85nm). The formulations, especially those containing argan oil, favoured the allantoin accumulation in the skin, in particular in the dermis (∼8.7μg/cm(2)), and its permeation through the skin (∼33μg/cm(2)). The performances of vesicles as skin d…
Über den Ureidstoffwechsel beim Laubmoosprotonema von Funaria hygrometrica L. (Sibth.)
1973
Summary 1. Allantoin and allantoic acid were about 6 % of the total nitrogen content of moss protonema (Funaria hygrornetica L.). 2. The level of endogenous allantoin depends on the spectrum colour of the irradiation. The peaks coincide with the peaks of a chlorophyll absorption spectrum from a methanolic extract of moss protonema. 3. The total amount of allan to in consists of two parts. One part is supplied by metabolism in darkness but the main one depends on light. Green- and far red light are “physiological dark conditions” for the moss protonema. In the dark ureide degradation comes to an end with allantoic acid. There are only traces of urea. 4. The coinciding correlations between th…
Über den Allantoinstoffwechsel des Laubmooskallus und seine Beeinflussung durch Licht
1972
Summary 1. The amount of allantoin and allantoate was determined in moss callus grown under various light conditions. It can reach 26,5 % of the plant nitrogen content. The accumulation is influenced by light intensity and colour. 2. Red-light (660 nm) causes a greater allantoin level in the cells than blue light and white light illumination. Red-light favours the formation of young setae from the moss callus. We could detect a relation between the intensity of seta-development and the amount of allantoin. The accumulation is increasing with the growth of the setae. 3. Blue-light (440 nm) enhances the chlorophyll synthesis and promotes chloroplast develop ment. This effect is correlated wit…
Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery …
2020
BACKGROUND: The aim of this study was to evaluate and compare the postoperative effect of a topic gel containing chlorhexidine, chitosan, allantoine and dexpanthenol versus a placebo for pain and inflammation control after third molar surgery. MATERIAL AND METHODS: A gel combining 0.2% chlorhexdine, 0.5% chitosan, 5% dexpanthenol, 0.15% allantoin and 0.01% sodium saccharin was selected for this split mouth randomized controlled and double-blind trial including 36 patients with bilaterally and symmetrically impacted lower third molars. The teeth (n=72) were randomly divided into two groups before surgical removal: control group (CG; in which a placebo was given) and experimental group (EG). …
The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted …
2016
Background Despite efforts to prevent postoperative discomfort, there are still many immediate side effects associated with the surgical extraction of impacted lower third molars. Cicatrization is a physiological process through which the loss of integrity of oral mucosa is recovered and damaged tissues are repaired. Bexident Post (ISDIN, Spain) is a topical gel that contains chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol. While this gel has many clinical indications, there are no published clinical trials evaluating its use in impacted mandibular third molar surgery. This study aims to clinically evaluate the efficacy of a gel containing chitosan, 0.2% chlorhexidine, allantoin an…
Über den Ureidstoffwechsel beim Laubmoosprotonema von Funaria hydrometrica L. (Sibth.)1)1)Herrn Prof. Dr. Dr. Kurt Mothes zum 75. Geburtstag gewidmet.
1975
Summary The activity of allantoinase (EC 3.5.2.5) is influenced by light and darkness. The extracts of dark-grown moss protonema showed a very higher enzyme activity than the extracts of light-grown plants. The allantoinase activity was increased by light-dark and decreased by dark-light transitions. DMAP mimicked light effects by stabelizing the charakteristic light depending enzyme avctivities in the dark. The inhibitors DCMU, DNP and CCCP increased the enzyme activity of light-grown moss protonema, to some extend they induced a “physiological dark condition”.