COMBINATION OF ARGAN OIL AND PHOSPHOLIPIDS FOR THE DEVELOPMENT OF AN EFFECTIVE LIPOSOME-LIKE FORMULATION ABLE TO IMPROVE SKIN HYDRATION AND ALLANTOIN DERMAL DELIVERY

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RESEARCH PRODUCT

COMBINATION OF ARGAN OIL AND PHOSPHOLIPIDS FOR THE DEVELOPMENT OF AN EFFECTIVE LIPOSOME-LIKE FORMULATION ABLE TO IMPROVE SKIN HYDRATION AND ALLANTOIN DERMAL DELIVERY

Marco Zaru Maria Manconi Elvira Escribano Virginia Melis José Esteban Peris Pietro Matricardi Maria Letizia Manca Anna Maria Fadda Claudia Carbone Claudia Cencetti

subject

3003 Pig skin food.ingredient Swine Chemistry Pharmaceutical Skin Absorption Pharmaceutical Science Argan oil 02 engineering and technology Administration Cutaneous 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems 0302 clinical medicine Allantoin food Dermis Elastic Modulus Skin rheology medicine Animals Plant Oils Allantoin Softening Phospholipids Skin Drug Carriers Liposome Chromatography integumentary system Chemistry Vesicle Liposomes; Argan oil; Phospholipids; Pig skin; Turbiscan lab; Skin rheology; Skin hydration Permeation 021001 nanoscience & nanotechnology Turbiscan lab medicine.anatomical_structure Skin hydration Argan oil Liposomes Dermatologic Agents 0210 nano-technology Drug carrier argan oil; liposomes; phospholipids; pig skin; skin hydration; skin rheology; turbiscan lab; 3003

description

Allantoin is traditionally employed in the treatment of skin ulcers and hypertrophic scars. In the present work, to improve its local deposition in the skin and deeper tissues, allantoin was incorporated in conventional liposomes and in new argan oil enriched liposomes. In both cases, obtained vesicles were unilamellar, as confirmed by cryo-TEM observation, but the addition of argan oil allowed a slight increase of the mean diameter (∼130nm versus ∼85nm). The formulations, especially those containing argan oil, favoured the allantoin accumulation in the skin, in particular in the dermis (∼8.7μg/cm(2)), and its permeation through the skin (∼33μg/cm(2)). The performances of vesicles as skin delivery systems were compared with those obtained by water dispersion of allantoin and the commercial gel, Sameplast(®). Moreover, in this work, for the first time, the elastic and viscous moduli of the skin were measured, underlining the different hydrating/moisturizing effects of the formulations. The application of ARG liposomes seems to provide a softening and relaxing effect on the skin, thus facilitating the drug accumulation and passage into and trough it.

year	journal	country	edition	language
2016-01-01

10.1016/j.ijpharm.2016.04.008 http://hdl.handle.net/20.500.11769/244111