Search results for "Allergy"
showing 10 items of 3181 documents
COVID-19 Vaccine-Related Thrombosis: A Systematic Review and Exploratory Analysis
2021
IntroductionThe World Health Organization declared the coronavirus disease 2019 (COVID-19) pandemic on March 11, 2020. Two vaccine types were developed using two different technologies: viral vectors and mRNA. Thrombosis is one of the most severe and atypical adverse effects of vaccines. This study aimed to analyze published cases of thrombosis after COVID-19 vaccinations to identify patients’ features, potential pathophysiological mechanisms, timing of appearance of the adverse events, and other critical issues.Materials and MethodsWe performed a systematic electronic search of scientific articles regarding COVID-19 vaccine-related thrombosis and its complications on the PubMed (MEDLINE) d…
El sueño roto de la ciudadanía europea y el lado oscuro de la gobernanza
2015
Este trabajo trata de analizar tres modelos de ciudadanía europea a partir de la crisis de legitimidad del modelo de gobernanza europeo a la que asistimos hoy. Presentaré los rasgos de esta crisis del modelo de gobernanza, aclarando cómo esta crisis pone de manifiesto 1) el poder de veto de algunos de los estados miembros 2) la falta de responsabilidad de las decisiones comunitarias hacia las opiniones públicas 3) la reducción de confianza mutua de los actores políticos y económicos. Mostraré como los tres modelos, respectivamente el modelo nacional- liberal, el modelo de la ciudadanía de mercado y el modelo federal, ofrecen diversas respuestas a la pregunta acerca del significado del ideal…
L'obiezione di coscienza come diritto.
2018
El artículo hace referencia al derecho de objeción de conciencia como un derecho constitucional general. Tal derecho no difiere del derecho a la libertad de conciencia que constituye su .fundamento y justificación. En el caso del derecho a la objeción de conciencia, la referencia a la Constitución representa su fuente de legitimidad, pero también un límite a su ejercicio. Estas restricciones dependen del respeto a otros valores constitucionales y de la razonabilidad de la entre los valores personales y los deberes impuestos por la ley. No necesariamente el derecho a la objeción de conciencia tiene que ser reconocido por el legislador; puede muy bien ser acogido por los jueces. Esto último p…
La vía europea de la razón pública
2012
El futuro de Europa es una cuestión que aglutina todas las energías y recursos culturales, sin excluir a nadie. El elevado grado de conflictualidad presente en Europa se ha debido en buena parte a la consolidación de formas de vida nacionales, ligadas auna larga elaboración histórica en la que los aspectos religiosos y civiles se han entrelazado de modo inextricable. La amenaza representada por reivindicaciones de libertades despreocupadas del bien común invierte la óptica rawlsiana de la razón pública. ¿Cómo sociedades políticas preexistentes pueden acoger el pluralismo sin ser abrumadas por una progresiva e ineluctable fragmentación de la esfera pública?. La vía europea de la razón públic…
Butyrophilin 3A1 presents phosphoantigens to human γδ T cells: the fourth model of antigen presentation in the immune system.
2013
Butyrophilin 3A1 presents phosphoantigens to human γδ T cells: the fourth model of antigen presentation in the immune system
Smoking, health and ageing.
2008
Abstract On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related diseases was held in Palermo, Italy. Here, the lecture of V. Nicita-Mauro on Smoking, health and ageing is summarized. Smoking represents an important ageing accelerator, both directly by triggering ana inflammatory responses, and indirectly by favoring the occurrence of several diseases where smoking is a recognized risk factor. Hence, non-smokers can delay the appearance of diseases and of ageing process, so attaining longevity.
Phenotypic and Immunometabolic Aspects on Stem Cell Memory and Resident Memory CD8+ T Cells
2022
The immune system, smartly and surprisingly, saves the exposure of a particular pathogen in its memory and reacts to the pathogen very rapidly, preventing serious diseases.Immunologists have long been fascinated by understanding the ability to recall and respond faster and more vigorously to a pathogen, known as “memory”.T-cell populations can be better described by using more sophisticated techniques to define phenotype, transcriptional and epigenetic signatures and metabolic pathways (single-cell resolution), which uncovered the heterogeneity of the memory T-compartment. Phenotype, effector functions, maintenance, and metabolic pathways help identify these different subsets. Here, we exam…
Phosphatidylserine liposomes reduce inflammatory response, mycobacterial viability and HIV replication in coinfected human macrophages
2021
AbstractChronic immune activation is the key pathogenetic event of Mycobacterium tuberculosis-human immunodeficiency virus (HIV) coinfection. We assessed the therapeutic value of phosphatidylserine-liposome (PS-L) in an in vitro model of M. tuberculosis-HIV coinfection. PS-L reduced nuclear factor-κB activation and the downstream production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 in bacille Calmette-Guérin-infected macrophages and of TNF-α and IL-1β in M. tuberculosis-infected and M. tuberculosis-HIV–coinfected macrophages. Importantly, a significant reduction of intracellular M. tuberculosis viability and HIV replication were also observed. These results suppor…
Distribution, function and predictive value of tumor-infiltrating γδ T lymphocytes
2013
Although γδ T cells are known to exert both tumor-preventing and tumor-promoting activity, there is still little information on the functional characteristics and clinical significance of γδ T cells isolated from the tumor site. In a recent study, we have investigated the distribution of different γδ T-cell populations in melanoma and their impact on disease outcome.
Non-celiac wheat sensitivity: a search for the pathogenesis of a self-reported condition
2019
A significant percentage of the general population reports gastrointestinal and non-gastrointestinal symptoms caused by wheat and/or gluten ingestion, even though they do not suffer from celiac disease (CD) or wheat allergy (WS), because they test negative both for CD-specific serology and histopathology. All patients report improvement of symptoms on a gluten-free diet. This clinical condition has been named non-celiac gluten sensitivity (NCGS). The objective of this paper was to review some studies regarding the pathogenesis of NCGS to summarize the current hypotheses about the mechanisms, which can lead to NCGS. Particular attention was given to the immunologic and the malabsorptive hypo…