6533b860fe1ef96bd12c3a40

RESEARCH PRODUCT

Distribution, function and predictive value of tumor-infiltrating γδ T lymphocytes

Matilde TodaroNadia CaccamoSerena MeravigliaFrancesco DieliGiorgio StassiAdriana Cordova

subject

Settore MED/04 - Patologia GeneraleTumor-infiltrating lymphocytesDisease outcomebusiness.industryMelanomaImmunologymedicine.diseasePredictive valueTumor siteγδ T cellscytokinesOncologytumor-infiltrating lymphocytesγδ T cells cytokines cytotoxicity melanoma tumor-infiltrating lymphocytesImmunologymedicinemelanomaImmunology and AllergycytotoxicityClinical significanceCytotoxicitybusinessAuthor's View

description

Although γδ T cells are known to exert both tumor-preventing and tumor-promoting activity, there is still little information on the functional characteristics and clinical significance of γδ T cells isolated from the tumor site. In a recent study, we have investigated the distribution of different γδ T-cell populations in melanoma and their impact on disease outcome.

10.4161/onci.23434http://europepmc.org/articles/PMC3654575