Search results for "Alpha"
showing 10 items of 3228 documents
Delivery of siHIF‐1α to Reconstruct Tumor Normoxic Microenvironment for Effective Chemotherapeutic and Photodynamic Anticancer Treatments
2021
The tumor hypoxic microenvironment not only induces genetic and epigenetic changes in tumor cells, immature vessels formation for oxygen demand, but also compromises the efficiency of therapeutic interventions. On the other hand, conventional therapeutic approaches which kill tumor cells or destroy tumor blood vessels to block nutrition and oxygen supply usually facilitate even harsher microenvironment. Thus, simultaneously relieving the strained response of tumor cells and blood vessels represents a promising strategy to reverse the adverse tumor hypoxic microenvironment. In the present study, an integrated amphiphilic system (RSCD) is designed based on Angiotensin II receptor blocker cand…
Reproducibility and validity of a food frequency questionnaire among pregnant women in a Mediterranean area
2013
Background: Studies exploring the role of diet during pregnancy are still scarce, in part due to the complexity of measuring diet and to the lack of valid instruments. The aim of this study was to examine the reproducibility and validity (against biochemical biomarkers) of a semi-quantitative food frequency questionnaire (FFQ) in pregnant women. Methods: Participants were 740 pregnant women from a population-based birth cohort study in Valencia (INMA Study). We compared nutrient and food intakes from FFQs estimated for two periods of pregnancy (reproducibility), and compared energy-adjusted intake of several carotenoids, folate, vitamin B12, vitamin C and a-tocopherol of the FFQ in the firs…
Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins.
2004
Recruitment and activation of polymorphonuclear neutrophils (PMNs) reflects a primary immunological response to invading pathogens and has also emerged as a hallmark of vascular inflammation. One of the principal enzymes released upon PMN activation is myeloperoxidase (MPO), a heme protein that not only generates cytotoxic oxidants but also impacts deleteriously on nitric oxide-dependent signaling cascades within the vasculature. Because MPO also associates with the membrane of PMN, we evaluated whether MPO could also function as an autocrine modulator of PMN activation. The extent of PMN membrane-associated MPO was elevated in patients with acute inflammatory vascular disease compared with…
User experience and the security of graphical passwords
2015
Graafiset salasanat ovat lupaava vaihtoehto alfanumeeriselle autentikaatiolle. Älypuhelinten ja muiden korkea resoluutioisten kosketusnäytöllisten laitteiden määrä on kasvussa ja alfanumeeriset salasanat ovat kehitetty alun perin näppäimistölle syötettäviksi. Tarkkuutta vaativa kirjoittaminen ei tällöin ole välttämättä käyttäjälle kaikkein mielekkäintä. Graafisia ja alfanumeerisia salasanoja on tutkittu muistin toiminnan sekä käytettävyyden näkökulmasta. Tutkielma on tehty kirjallisuuden pohjalta käyttäen apuna erilaisia tieteellisia julkaisuja sisältäviä tietokantoja, kuten IEE Explore ja ACM Digital Library - tietokantoja. Tutkielman tarkoituksena oli kuvata ja tutkia tieteellisten artikk…
Brain oscillations: discovering their role in memory using Transcranial Alternating Current Stimulation
Branched-Chain Amino Acid Deprivation Decreases Lipid Oxidation and Lipogenesis in C2C12 Myotubes
2022
Impaired lipid metabolism is a common risk factor underlying several metabolic diseases such as metabolic syndrome and type 2 diabetes. Branched-chain amino acids (BCAAs) that include valine, leucine and isoleucine have been proven to share a role in lipid metabolism and hence in maintaining metabolic health. We have previously introduced a hypothesis suggesting that BCAA degradation mechanistically connects to lipid oxidation and storage in skeletal muscle. To test our hypothesis, the present study examined the effects of BCAA deprivation and supplementation on lipid oxidation, lipogenesis and lipid droplet characteristics in murine C2C12 myotubes. In addition, the role of myotube contract…
The Italian Society of Gastroenterology (SIGE) and the Italian Group for the study of Inflammatory Bowel Disease (IG-IBD) Clinical Practice Guideline…
2010
Biological therapies are an important step in the management of Inflammatory Bowel Diseases. In consideration of high cost and safety issues there is the need to have clear recommendations for their use. Despite the American Gastroenterological Association and the European Crohn's and Colitis Organisation have published exhaustive Inflammatory Bowel Disease guidelines, national guidelines may be necessary as cultural values, economical and legal issues may differ between countries. For these reasons the Italian Society of Gastroenterology and the Italian Group for the study of Inflammatory Bowel Disease have decided to elaborate the Italian guidelines on the use of biologics in Inflammatory…
Is there a microbial sub alpha-diversity at soil microscale ?
2012
The distribution of the soil microbial diversity depends on a broad range of environmental filters nested in spatial scales from continent to millimeter. Although microbial biogeography studies have recently shown the influence of environmental factors (texture/pH/plant cover and land-use) on soil microbial abundance and diversity, little is still known about spatial heterogeneity at a micro-scale within soil. Our study aims at describing and understanding the distribution of abundance and diversity of soil microbial communities between different soil microenvironments. Four soils were selected on the basis of differences in physico-chemical properties and historical land-management practic…
Alpha frequency discrepancy and trait anxiety, activation, and inhibition in states of anxiety and mindfulness
2018
Meditaatiotekniikat tarjovat laajalti mahdollisuuksia hyvinvoinnin ylläpitämiseen ja kehittämiseen sekä stressin lievittämiseen. Useat neurotieteelliset tutkimukset ovat osoittaneet välittömiä tuloksia meditatitiivisten tekniikoiden soveltamisen ja aivojen oskillatoristen mekanismien välisessä suhteessa. Meditaatiolla on osoitettu olevan myös pitkäaikaisia vaikutuksia, joihin sisältyy ahdistuneisuuden ja murheen väheneminen. Keskittymistä tukevan aivokäyttöliittymän alustavan suunnittelun tueksi tutkittiin alpha-aallonpituuden käyttäytymistä ahdistuneisuuden ja mindfulnessin tiloissa ja niiden välisiä eroja lähestyttiin aktivaatio-/inhibitio -persoonallisuuspiirteiden sekä ahdistuneisuuteen…
Edu-social Algorithm: educare con i social network a scuola. Un modello operativo per il Mobile Learning
2023
In questo lavoro si mostreranno i presupposti teorici e operativi per lo sviluppo di un Mobile Learning capace di coniugare didattica in presenza ed esperienze digitali, sfruttando Instagram come social media privilegiato per una proposta di un modello metodologico volto a strumentalizzare le funzioni multimediali e interattive interne all’applicazione. I risultati qualitativi del progetto di ricerca-azione Edu-social Algorithm mostrano una serie di contenuti mediaeducativi che evidenziano il potenziale pedagogico dentro il social media Instagram e la replicabilità del modello metodologico sviluppato.