Search results for "Alzheimer"

OXIDATIVE STRESS AND ALZHEIMER’S DISEASE

2012

Introduction: Brain tissue is particularly susceptible to oxidative damage, which has been associated with pathological findings of Alzheimer’s disease (AD), such as amyloid plaques and protein fibrils. Oxidative stress alterations, including increased production of reactive oxygen metabolites, decline of antioxidant systems, and decreased efficiency in repairing damaged molecules, have been linked to the development of AD. Postmortem studies on brain tissue from AD patients have shown several oxidative damage markers, such as increased lipid peroxidation, oxidative damage of proteins, glyco-oxidation, and reduction of antioxidant enzyme systems. Methods: We studied 40 patients referred to …

INTERVENTI SUL CAREGIVER DEL PAZIENTE CON DEMENZA

2009

Nutritional prevention of cognitive decline and dementia.

2018

Cognitive impairment results from a complex interplay of many factors. The most important independent predictor of cognitive decline is age but other contributing factors include demographic, genetic, socio-economic, and environmental parameters, including nutrition. The number of persons with cognitive decline and dementia will increase in the next decades in parallel with aging of the world population. Effective pharmaceutical treatments for age-related cognitive decline are lacking, emphasizing the importance of prevention strategies. There is extensive evidence supporting a relationship between diet and cognitive functions. Thus, nutritional approaches to prevent or slow cognitive decli…

TYPE 2 DIABETES AND ALZHEIMER’S DISEASE

2014

Epidemiological and biological evidences support a link between type 2 diabetes mellitus (DM2) and Al-zheimer’s disease (AD). Persons with diabetes have a higher incidence of cognitive decline and an increased risk of developing all types of dementia. Cognitive deficits in persons with diabetes mainly affect the ar-eas of psychomotor efficiency, attention, learning and memory, mental flexibility and speed, and executive function. The strong epidemiological association has suggested the existence of a physiopathological link. The determinants of the accelerated cognitive decline in DM2, however, are less clear. Increased cortical and subcortical atrophy have been evidenced after con-trolling…

Methodological matters on an Alzheimer's dementia trial: is a double-blind randomized controlled study design sufficient to draw strong conclusions o…

2007

Letter to Editor

Combination of intensive cognitive rehabilitation and donepezil therapy in Alzheimer’s disease.

2009

DEFICIT COGNITIVO E DIABETE MELLITO. STUDIO OSSERVAZIONALE

2009

Metabolomic analysis of plasma from Alzheimer disease patients

2011

Alzheimer Disease is a degenerative disease characterized by progressive impairment of cognitive function. The main feature of AD the generation of an abnormal peptide, beta amyloid 42 (Ab42) from Amyloid Precursor Protein (APP). Ab42 is the main constituent of neurotangles and amyloid plaques, microscopic lesions found in AD patients brain. Ab42 triggers an inflammatory response that is responsible for most of the observed tissue damage. The diagnosis of AD is a complex task, mostly based on imaging techniques and clinical evaluation of the patient’s neurological and cognitive functions. The search for plasma biomarkers able to detect early mild cognitive impairment is one of the recent at…

APPROCCI NUTRIZIONALI NELLA PREVENZIONE DEL DECLINO COGNITIVO E DELLA MALATTIA DI ALZHEIMER

2017

Vi sono consistenti evidenze epidemiologiche a supporto di una stretta relazione tra alimentazione, de-clino cognitivo e malattia di Alzheimer. È ipotizzabile che il rischio di declino cognitivo nell’anziano possa essere ridotto tramite appropriati interventi dietetici, e che l’adozione di una dieta e di uno stile di vita sani possano contribuire a ritardare l’insorgenza del-la malattia di Alzheimer, anche grazie alla potenzia-le azione sulla prevenzione della aterosclerosi. Sono state studiate diverse sostanze nutritive, componenti alimentari, integratori e modelli dietetici in relazione alla loro associazione con la performance cognitiva e con lo sviluppo del declino cognitivo e della dem…

IL TESTAMENTO BIOLOGICO NEL PAZIENTE AFFETTO DA DEMENZA: CONSIDERAZIONI BIOETICHE E SUGGERIMENTI NELLA PRATICA CLINICA

2017

La demenza rappresenta oggi una delle principali priorità del sistema sanitario, in termini sia clinici che assistenziali, con un importante impatto sulla popola-zione mondiale. Un recente report redatto dalla comunità scientifica ha evidenziato come circa 46 milioni di soggetti hanno ricevuto diagnosi di demenza nel corso del 2015. Il trend intrapreso suggerisce che questa cifra possa aumentare progressivamente in futuro: è stimato che circa 130 milioni di persone saranno affette da demenza nei prossimi quarant’anni. Nonostante la cruda sincerità di tali numeri, il progresso delle conoscenze cliniche nel campo delle demenze non sempre ha progredito di pari passo con il miglioramento dei mo…