Search results for "Amide"

PREPARAZIONE, CARATTERIZZAZIONE E STUDI DI DEGRADAZIONE CHIMICA DI NUOVI SISTEMI POLIMERICI NANOPARTICELLARI A BASE DI COPOLIMERI ANFIFILICI DI UNA α…

2014

Synthesis and biological evaluation of some new 2-phenylpropiolamidobenzamides as potential antagonists of the HMDM2-p53 protein-protein interactions

2009

PtII versus PdII-assisted [2+3] cycloadditions of nitriles and nitrone. Synthesis of nitrile-derived arylamido platinum(II) and Δ4-1,2,4-oxadiazoline…

2019

Abstract The reactions of bis(organonitrile) platinum(II) complexes trans-[PtCl2(N CR)2] (R = C6H4(p-HC O), CH2C6H4(p-CH3)) with pyrroline N-oxide −O+N CHCH2CH2CMe2 afford arylamido platinum(II) complexes trans-[PtCl2{(O CR)N CCH2CH2CMe2NH}2] (R = C6H4(p-HC O) (1), CH2C6H4(p-CH3) (2)). The spectral data of 1 and 2 show that the oxadiazoline rings in both cases have opened by a spontaneous N O bond cleavage to form (Z)-p-formyl-N-(5,5-dimethylpyrrolidin-2-ylidene)benzamide or (Z)-N-(5,5-dimethylpyrrolidin-2-ylidene)-2-p-tolylacetamide ligands, respectively, where the N-atoms of the benzamide or acetamide moieties coordinate to platinum(II) metal centre in trans positions. However, the reacti…

Amphoteric, prevailingly cationic L-arginine polymers of poly(amidoamino acid) structure: Synthesis, acid/base properties and preliminary cytocompati…

2013

A linear amphoteric poly(amidoamino acid), L-ARGO7, is prepared by Michael-type polyaddition of L-arginine with N,N′-methylenebisacrylamide. Chain-extension of acrylamide end-capped L-ARGO7 oligomers with piperazine leads to high-molecular-weight copolymers in which L-arginine maintains its absolute configuration. Acid/base properties of L-ARGO7 polymers show isolectric points of ≈10 and positive net average charges per repeating unit at pH = 7.4 from 0.25 to 0.40. These arginine-rich synthetic polymers possibly share some of the unique biological properties of polyarginine cell-permeating peptides. In vitro tests with mouse embryo fibroblasts balb/3T3 clone A31 show that L-ARGO7 polymers a…

Elévation de température au sein d'une éprouvette de polyamide sous sollicitation de traction dynamique

2007

National audience

DEGRADATION STUDIES OF NOVEL POLYMERIC NANOPARTICLES BASED ON AMPHIPHILIC POLYLACTIC ACID-POLYASPARTAMIDE DERIVATIVES

2014

Design of New Polyaspartamide Copolymers for siRNA Delivery in Antiasthmatic Therapy

2020

Here, a novel protonable copolymer was realized for the production of polyplexes with a siRNA (inhibitor of STAT6 expression in asthma), with the aim of a pulmonary administration. The polycation was synthesized by derivatization of &alpha

On the Preparation and the Characterization of Polyethylene/Polyamide Blends by Melt Processing in the Presence of an Ethylene(co)acrylic Acid Copoly…

2006

Samples of HDPE and PA6 have been meltprocessed in the presence of two new phosphazene compounds, CP-2EPOX and CP-2OXA together with an ethylene/ acrylic acid copolymer. The blends have been prepared in an industrial twin-screw extruder by using PA6 and PE in weight ratios of 25/75 and 75/25. When used, 5 phr of EAA and 0.2 phr of CP have been added. The materials have been completely characterized from a rheological, morphological, and mechanical point of view. The results indicate that the additives used caused an increase in the rupture tensile properties, of the impact strength and viscosity especially in the PE-rich blend in the presence of CP-2EPOX. This result can be attributed both …

The role of organoclay in the morphology modification and in the properties in polyethylene/polyamide blend systems

2009

Realization of polyaspartamide-based nanoparticles and in vivo lung biodistribution evaluation of a loaded gucocorticoid after aerosolization in mice

2016

Abstract In this study, novel polymeric nanoparticles (NPs) were developed and their potential as carriers for beclomethasone dipropionate (BDP) into the lung after aerosolization was demonstrated by in vivo studies in mice. In particular, these NPs were obtained starting from two polyaspartamide-based copolymers which were synthesized by chemical reaction of α,β-poly(N-2-hydroxyethyl)- dl -aspartamide (PHEA) and its pegylated derivative (PHEA-PEG2000) with poly(lactic acid) (PLA). To obtain nanosized particles, the high pressure homogenization (HPH)—solvent evaporation method was followed by using an organic phase containing both PHEA-PLA and PHEA-PEG2000-PLA (at a weight ratio equal to 1:…