Search results for "Amy"

G-CSF (filgrastim) treatment for amyotrophic lateral sclerosis: protocol for a phase II randomised, double-blind, placebo-controlled, parallel group,…

2020

IntroductionAmyotrophic lateral sclerosis (ALS) is a fatal progressive neurological disorder characterised by a selective degeneration of motor neurons (MNs). Stem cell transplantation is considered as a promising strategy in neurological disorders therapy and the possibility of inducing bone marrow cells (BMCs) to circulate in the peripheral blood is suggested to investigate stem cells migration in degenerated ALS nerve tissues where potentially repair MN damage. Granulocyte-colony stimulating factor (G-CSF) is a growth factor which stimulates haematopoietic progenitor cells, mobilises BMCs into injured brain and it is itself a neurotrophic factor for MN. G-CSF safety in humans has been de…

Response to the letter to the Editor: Comments on marital status is a prognostic factor in amyotrophic lateral sclerosis. Safiri S et al

2018

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention

2014

// Nicole M. Davis 1 , Melissa Sokolosky 1 , Kristin Stadelman 1 , Stephen L. Abrams 1 , Massimo Libra 2 , Saverio Candido 2 , Ferdinando Nicoletti 2 , Jerry Polesel 3 , Roberta Maestro 4 , Antonino D’Assoro 5 , Lyudmyla Drobot 6 , Dariusz Rakus 7 , Agnieszka Gizak 7 , Piotr Laidler 8 , Joanna Dulinska-Litewka 8 , Joerg Basecke 9 , Sanja Mijatovic 10 , Danijela Maksimovic-Ivanic 10 , Giuseppe Montalto 11,12 , Melchiorre Cervello 12 , Timothy L. Fitzgerald 13 , Zoya N. Demidenko 14 , Alberto M. Martelli 15 , Lucio Cocco 15 , Linda S. Steelman 1 and James A. McCubrey 1 1 Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA 2 …

Mniejszość Niemiecka w prasie regionalnej w sytuacji konfliktu. Framing i agenda medialna w ramach sporu o „Duże Opole”

2017

Jednym ze wskaźników kondycji państwa demokratycznego jest jego stosunek do mniejszości narodowych. Istotny jest nie tylko wymiar formalny tych relacji, ale także funkcjonowanie sfery publicznej. Kluczowa będzie zatem zdolność do efektywnego negocjowania i deliberacji nad kwestiami ważnymi dla społeczności i budzącymi duże emocje. Naturalną przestrzeń dla takiej debaty stwarzają media, które ukazują przedmiot sporu i stanowiska stron. Będąc również uczestnikiem debaty, media pozycjonują strony i wpływają na postawy społeczne wobec dyskutowanych kwestii. Celem badań, których wyniki są prezentowane w niniejszym artykule była analiza medialnego pozycjonowania mniejszości niemieckiej (MN) w ram…

Generation of localized pulses from incoherent wave in optical fiber lines made of concatenated Mamyshev regenerators

2008

International audience; We investigate the novel properties of optical fiber lines made of Mamyshev regenerators (MRs) based on self-phase modulation and subsequent spectral filtering. In particular, we show that such a regenerator line can be used to generate random sequences of optical pulses from an incoherent wave. This behavior is related to the existence of stable eigenpulses that can propagate unchanged through the regenerator line and act as attractors for incoming pulses. By changing the regenerator parameters, we also report the existence of multiple eigenpulses and limit cycles. Finally, we demonstrate that MRs could be used as efficient nonlinear gates in fiber laser cavities.

A New Benzopyranyl Cadenane Sesquiterpene and Other Antiplasmodial and Cytotoxic Metabolites from Cleistochlamys kirkii

2019

Phytochemical investigations of ethanol root bark and stem bark extracts of Cleistochlamys kirkii (Benth.) Oliv. (Annonaceae) yielded a new benzopyranyl cadinane-type sesquiterpene (cleistonol, 1) alongside 12 known compounds (2&ndash

Kościół dla wybranych? O specyfice indyjskich chrześcijan knānāya

2015

Nazwą knānāya (także „południowcy”) określa się jedno z ramion indyjskiego chrześcijaństwa, którego członkowie doszukują się swojej genezy w starożytnej emigracji perskich chrześcijan, przybyłych do Indii pod przewodnictwem kupca Tomasza z Kany. Charakterystyczną cechą tej grupy jest silne przywiązanie do tradycji i bezwarunkowa ochrona tożsamości łączącej współczesnych „południowców” z ich przodkami. Sam fakt głębokiego przywiązania do tradycji i w konsekwencji jej silna ochrona nie powinien dziwić, wszak jest to jedno z podstawowych praw każdej wspólnoty i każdego człowieka. Jednakże knanaici, chcąc zachować „czystość krwi”, zupełnie nie dopuszczają do siebie niczego i nikogo z zewnątrz. …

Molecular analysis of a human liver mitochondrial ornithine transcarbamylase deficiency.

1990

The liver of a young girl which had been successfully transplanted was investigated at the ornithine transcarbamylase (OTC, EC 2.1.3.3) gene expression level. Northern blot hybridization using a human OTC cDNA probe showed a greater than 80% decrease in specific OTC mRNA although having the same molecular size as a normal control. OTC polypeptide was simultaneously synthesized with a normal molecular size but at a low level (20%) as shown by immunoblotting. The OTC enzyme from the deficient liver exhibited very little catalytic activity (7.2% as compared to the normal subject). These results may support several explanations of this disease such as mutation of the OTC gene promoter leading t…

Amylase production in submerged culture using principal component analysis

1989

Abstract The aim of our work was to study the production of α-amylase and glucoamylase in submerged culture by a species of Aspergillus niger screened for its high amylase activity. Statistical analysis was not used to optimize fermentation conditions but it was employed in a new approach to describe the culture behaviour. Principal component analysis (PCA) was applied to describe the influence of three agitation speeds on the rate of amylases synthesis and on the evolution of other indirect growth factors. The results of this analysis showed that the oxygen transfer at various agitation speeds affected the levels of enzymes, their production rates and the CO 2 production rate (indirect mea…

C172S Substitution in the Chloroplast-encoded Large Subunit Affects Stability and Stress-induced Turnover of Ribulose-1,5-bisphosphate Carboxylase/Ox…

1999

Previous work has indicated that the turnover of chloroplast ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco; EC 4.1.1. 39) may be controlled by the redox state of certain cysteine residues. To test this hypothesis, directed mutagenesis and chloroplast transformation were employed to create a C172S substitution in the Rubisco large subunit of the green alga Chlamydomonas reinhardtii. The C172S mutant strain was not substantially different from the wild type with respect to growth rate, and the purified mutant enzyme had a normal circular dichroism spectrum. However, the mutant enzyme was inactivated faster than the wild-type enzyme at 40 and 50 degrees C. In contrast, C172S mutant …