Search results for "Amy"

O czary, próbę spędzenia płodu, bigamię i czyny nierządne. Proces Barbary z Krzyżanowskich 1o Krępska, 2o Lenartowiczowej w Barze w 1764 roku. Edycja…

2022

Wzmiankowany w tytule proces sądowy odbył się 18 lipca 1764 roku. Oskarżono w nim Barbarę z Krzyżanowskich primo Krępską, secundo Lenartowiczową o przywłaszczenie spadku po mężu, który zgodnie z prawem powinien przypaść jego córce z pierwszego małżeństwa Annie. Sprawę do sądu wniósł jej mąż Jan Szcześniacki. W trakcie procesu okazało się, że Barbara winna była jeszcze kilku innych przestępstw zagrożonych bezwzględną karą śmierci jak bigamia, próba przerwania ciąży oraz kontakty intymne z parobkiem Iwanem Zemkowem, który z tego powodu był wyśmiewany przez kolegów. Jednym z poważnych zarzutów były czary, które oskarżona miała rzekomo rzucić na kochanka oraz byłego męża, który z ich powodu mia…

Specific sequence elements in the 5′ untranslated regions of rbcL and atpB gene mRNAs stabilize transcripts in the chloroplast of Chlamydomonas reinh…

2001

Using a series of point mutations in chimeric reporter gene constructs consisting of the 5' regions of the Chlamydomonas chloroplast rbcL or atpB genes fused 5' to the coding sequence of the bacterial uidA (GUS) gene, RNA-stabilizing sequence elements were identified in vivo in the 5' untranslated regions (5' UTRs) of transcripts of the chloroplast genes rbcL and atpB in Chlamydomonas reinhardtii. In chimeric rbcL 5' UTR:GUS transcripts, replacement of single nucleotides in the 10-nt sequence 5'-AUUUCCGGAC-3', extending from positions +38 to +47 relative to the transcripts' 5' terminus, shortened transcript longevity and led to a reduction in transcript abundance of more than 95%. A similar…

Changes in the 5?-untranslated region of the rbcL gene accelerate transcript degradation more than 50-fold in the chloroplast of Chlamydomonas reinha…

2003

Using uidA (beta-glucuronidase; GUS) reporter gene constructs, the 5'-untranslated region (UTR) of the Chlamydomonas chloroplast rbcL gene was screened by deletion and mutational analysis for the presence of a promoter element that previous studies implied to reside within the first 63 base pairs of the UTR. Deleting a large segment of the rbcL 5'UTR in a 3'--5' direction to position +36, changing the remaining 36 base pairs at the 5' end of the UTR, and increasing by five base pairs the distance between the rbcL 5'UTR and the basic promoter element located at position -10 did not abolish transcription from the basic rbcL promoter. It is concluded that the apparent loss of transcriptional a…

P3‐335: Upstream of N‐ras (UNR) is involved in translational control of ADAM10 protein expression

2008

Background: The amyloid beta peptide (A ) is derived by proteolytic processing of the amyloid precursor protein (APP) by the beta-secretase BACE1 and gamma-secretase. In contrast to this amyloidogenic processing, APP is predominantly cleaved by the alpha-secretase within the A domain and this precludes the formation of A . We and other research groups could show that BACE1 protein expression is regulated by the 5’untranslated region (UTR) of the BACE1 mRNA, however little is known about the regulation of alpha-secretase. Similar to the 5’UTR of BACE1, the 5’UTR of ADAM10 consists of 444 nucleotides with a GC-content of 70% and two upstream open reading frames. We hypothesize that ADAM10, th…

Hippocampal and Amygdalar Volumes Changes in Drug Addicts: A Preliminary Study

2007

Oral comunication for American Society of Neuroradiology 45th Annual Meeting. Chicago, June 9-14 2007

Post H1N1 vaccination narcolepsy–cataplexy with decreased CSF beta-amyloid

2012

Fatigue, sleep, and nocturnal complaints in patients with amyotrophic lateral sclerosis

2012

Background and purpose: Fatigue is a common symptom in amyotrophic lateral sclerosis (ALS). Although sleep disturbances are a candidate factor that may interfere with fatigue in patients with ALS, the role of sleep-related abnormalities in determining fatigue in ALS is unknown. Objective: To evaluate the frequency and determinants of fatigue in a group of 91 consecutive patients with ALS, with special attention to the relationship between fatigue and sleep problems. Methods: Measures included the Fatigue Severity Scale (FSS), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), ALS Functional Rating ScaleRevised (ALSFRS-R), and Beck Depression Inventory (BDI). Results: The…

Nusinersen in adult patients with 5q spinal muscular atrophy: a multicenter observational cohorts’ study

2021

ABSTRACTObjectiveTo assess safety and efficacy of nusinersen in adult 5q spinal muscular atrophy (SMA) patients.MethodsPatients older than 15 years and followed at least for 6 months with one motor scale (Hammersmith Functional Motor Scale Expanded, HFMSE; Revised Upper Limb module, RULM) in five referral centers were included. Clinical and patients’ global impression of change (CGI-C and PGI-C) were recorded in treated patients at the last visit. Functional scales (Egen Klassification, EK2; Revised Amyotrophic Lateral Sclerosis Functional Rating Scale, ALSFRS-R) and the percent-predicted forced vital capacity were collected when available.ResultsSeventy-nine SMA patients (39 treated with n…

Fat storing cells (FSC) of rat liver synthesize and secrete fibronectin

1987

Summary Fat storing cells (FSC) of rat liver were isolated and kept in culture for up to 2 weeks. Freshly isolated cells and cells in culture were characterized functionally (vitamin A content) and morphologically. Their synthetic capacity for fibronectin was studied quantitatively by ELISA-measurement and qualitatively by biosynthetic labeling, immunoprecipitation and SDS-PAGE analysis. The synthesis product and the kinetics of the synthesis and secretion were compared with those obtained from culture of hepatocytes. FSC were shown to synthesize and secrete fibronectin under the culture conditions used. No fibronectin synthesis was detected during the first 3 days of culture. Thereafter th…

Ingestion, digestion, and egestion in Spongilla lacustris (Porifera, Spongillidae) after pulse feeding with Chlamydomonas reinhardtii (Volvocales)

1993

The route followed by food particles in Spongilla lacustris was clarified by light and electron microscopic examination of sponges fed with Chlamydomonas reinhardtii. The algal cells are phagocytosed by prosendopinacocytes and choanocytes. After some time they are transferred to archaeocytes, amoebocytes, and lophocytes. Changes in algal structure during digestion were observed and the egestion of algal remnants was documented in life for the first time. In light micrographs, digestion of the algal cells is manifest first in shrinkage of the cells, then in disintegration to form several spherical green fragments 2–3 μm in diameter, and finally, after 12–18 h, in a reddish brown discoloratio…