Search results for "Amy"
showing 10 items of 1486 documents
The medial amygdala as a key neural centre in maternal aggression: genetic, neural and behavioural analyses
2019
In rodents, as macrosmatic animals, chemosensory processing plays an instrumental role in guiding the expression of social, sexual and maternal behaviours. Social odours and pheromones are processed by the main and the accessory olfactory systems, which information converge mainly in the medial amygdala (Me). The Me, in turn, plays a central role in the vomeronasal–sensorimotor integration that leads to specific behavioural responses such as the above-mentioned social and maternal behaviours. Maternal behaviour comprises physiological and behavioural adaptations that help the dams to successfully raise their offspring. This behaviour is expressed in a wide range of vertebrate species and ca…
Impact of pharmacological and environmental manipulations on neuronal structural plasticity and dynamics
2017
El sistema nervioso de vertebrados es uno de los más estudiados, aunque peor comprendidos, del organismo de mamíferos. Desde que Ramón y Cajal postuló su teoría celular de este sistema (Ramón y Cajal 1909), la neurona se ha postulado como su unidad funcional. Sin embargo, durante las últimas décadas se ha revolucionado la visión que se tenía de éste. Una de las percepciones más asentadas era que, tras el desarrollo embrionario, el sistema nervioso se mantenía inmutable. Sin embargo, ahora sabemos que diferentes formas de plasticidad gobiernan su adaptación, que son necesarias para importantes procesos del día a día, tales como el aprendizaje y la memoria (Smythies 2002; Berlucchi and Buchte…
Amygdaloid projections to the ventral striatum in mice: direct and indirect chemosensory inputs to the brain reward system
2011
Rodents constitute good models for studying the neural basis of socio-sexual behaviour. Recent findings in mice have revealed the molecular identity of the some pheromonal molecules triggering intersexual attraction. However, the neural pathways mediating this basic socio-sexual behaviour remain elusive. Since previous work indicates that the dopaminergic tegmento-striatal pathway is not involved in pheromone reward, the present report explores alternative pathways linking the vomeronasal system with the tegmento-striatal system (the limbic basal ganglia) by means of tract-tracing experiments studying direct and indirect projections from the chemosensory amygdala to the ventral striato-pall…
Exploring Obutyamye as Material Citizenship in Busoga Subregion, Uganda
2022
This article explores how being a citizen is inexorably bound up with the resources individuals own and deploy to support livelihoods in the rural locations of postcolonial states. Drawing on the works of Kabeer (2006) and Baglioni (2016), the article zooms in on how citizenship is manifestly and inescapably material in the Busoga subregion of eastern Uganda. Data for the article were collected using qualitative methods among beneficiaries of antipoverty programmes implemented by Action for Development (ACFODE), a national non-governmental organization (NGO). Findings show that, locally, citizenship is understood as obutyamye, connoting an (un)equal experience of being in, for and with the …
Mediating effects of motor performance, cardiorespiratory fitness, physical activity, and sedentary behaviour on the associations of adiposity and ot…
2018
We investigated the associations of cardiometabolic risk factors with academic achievement and whether motor performance, cardiorespiratory fitness, physical activity, or sedentary behaviour mediated these associations. Altogether 175 children 6-8 years-of-age participated in the study. We assessed body fat percentage (BF%), waist circumference, insulin, glucose, triglycerides, HDL cholesterol, and systolic and diastolic blood pressure, leptin, alanine aminotransferase, and gamma-glutamyltransferase (GGT). Reading fluency, reading comprehension, and arithmetic skills were assessed using standardized tests. Speed/agility, balance, and manual dexterity test results were used to calculate moto…
Oxidative alteration of Human Serum Albumin Amyloid Aggregation Pathway
2013
Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS.
2005
Phosphorylated p38 mitogen-activated protein kinase (p38MAPK), but not activated c-jun-N-terminal kinase (JNK), increases in the motor neurons of transgenic mice overexpressing ALS-linked SOD1 mutants at different stages of the disease. This effect is associated with a selective increase of phosphorylated MKK3-6, MKK4 and ASK1 and a concomitant upregulation of the TNFalpha receptors (TNFR1 and TNFR2), but not IL1beta and Fas receptors. Activation of both p38 MAPK and JNK occurs in the activated microglial cells of SOD1 mutant mice at the advanced stage of the disease; however, this effect is not accompanied by the concomitant activation of the upstream kinases ASK1 and MKK3,4,6, while both …
Partnerattiecībās esošu pieaugušo pamatojums iesaistīties monogāmās, konsensuāli un nekonsensuāli nemonogāmās seksuālās attiecībās
2020
Pētījuma mērķis bija noteikt, vai pastāv statistiski nozīmīgas atšķirības pamatojumā iesaistīties seksuālās attiecībās monogāmo un nemonogāmo respondentu grupās un vai nemonogāmo personu grupā pastāv statistiski nozīmīgas atšķirības pamatojumā iesaistīties seksuālās attiecībās ar saviem dažādajiem partneriem. Lai izpētītu motivāciju iesaistīties seksuālās attiecībās monogāmo, nekonsesnuāli nemonogāmo, konsensuāli nemonogāmo (poliamoro, svingeru un atvērto attiecību) pārstāvju grupās, tika izmantota modificētā un papildinātā YSEX? aptauja (Meston & Buss, 2007). Pētījuma ietvaros tika iegūtas atbildes uz abiem jautājumiem – vairākumā no modificētas YSEX? aptaujas jautājumiem pastāv statistisk…
Genetic analysis of familial Alzheimer’s disease, primary lateral sclerosis and paroxysmal kinesigenic dyskinesia: a tool to uncover common mechanist…
2021
Tesis doctoral 270 p. figuras y tablas
Przyczyny transferów poselskich w Sejmie w latach 2001-2015
2018
Celem niniejszego artykułu jest określenie przyczyn zmiany przynależności klubowej w Sejmie w latach 2001-2015. Pod pojęciem „transferu” rozumiane są wszelkie zmiany przynależności klubowej mające miejsce w trakcie kadencji Sejmu, takie jak: rozłamy, odejścia, przejścia. Transfery takie mogą istotnie zmienić układ sil wewnątrz parlamentu ukształtowany w wyborach. Intencją autora jest wskazanie przyczyn tego zjawiska w Sejmie oraz jego kategoryzacja. Dokonana analiza pokazuje zasadnicze metodologiczne trudności z określeniem obiektywnych przyczyn transferów. Najczęściej wskazuje się różnice ideowo-programowe, jednakże analiza uwarunkowań, w których transfery się dokonują sugeruje, że często …